Affiliations
Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Junior Principal Investigator, Cancer Science Institute of Singapore
Biodata
Yvonne Tay received her PhD in 2008 from the National University of Singapore and Genome Institute of Singapore (GIS). Her PhD work, which was supported by an A*STAR Graduate Scholarship, led to seminal contributions to our understanding of the mechanisms of microRNA function which were published in Cell and Nature. Yvonne was awarded the 2009 Philip Yeo Prize for Outstanding Achievement in Research by A*STAR in recognition of these breakthrough discoveries. After a two year postdoctoral stint at A*STAR, Yvonne subsequently received a Special Fellow award from the Leukemia Lymphoma Society to continue her postdoctoral training at Harvard Medical School and Beth Israel Deaconess Medical Center. Her postdoctoral research in the Pandolfi lab led to the discovery that protein-coding transcripts can co-regulate the tumor suppressor PTEN by competing for shared microRNAs. This work was published in Cell and has wide-ranging implications for both cancer biology and potential therapeutic applications. She has recently commenced her new appointments as an Assistant Professor in the Department of Biochemistry and Junior Principal Investigator at the Cancer Science Institute of the National University of Singapore in September 2014.
Research Interest
Yvonne Tay’s laboratory focuses on:
Characterization of non-coding RNA regulatory networks in cancer
Selected Publications
- Tay Y, Rinn J, Pandolfi PP. (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature. 505, 344-352.
- Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. (2011) Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147, 344–357.
• Selected by Faculty of 1000 - Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. (2011) In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147, 382–395.
- Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455(7216),1124-1128.
• Selected by Faculty of 1000 - Miranda KC*, Huynh T*, Tay Y*, Ang YS*, Tam WL, Thomson AM, Lim B, Rigoutsos I. (2006) A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126(6), 1203-1217.