Affiliations
Assistant Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Principle Investigator, NUS Medicine Synthetic Biology Translational Research Programme
Vice Chairman, Korean Association for Genome Editing
Member, American Society of Gene & Cell Therapy
Life Member, The Oxford and Cambridge Society of Singapore
Member, Stanford Club of Singapore.
Education
| Degree and Institution | Year(s) |
| Ph.D. Stanford University | 2005 – 2011 |
| B.A. M.Sci University of Cambridge | 2001 – 2005 |
Professional Experience
| Position and Institute | Year(s) |
| Biotherapeutics Lab, Samsung Advanced Institute of Technology | 2011 – 2014 |
| The Institute of Molecular Biology & Genetics, Seoul National University | 2014 – 2016 |
| Platform R&D, Toolgen | 2016 – 2024 |
Research Interest
Advancement of platform technologies for genome editing and broadening their applications.
Current Research Projects
- Investigating the directed evolution of CRISPR and related enzymes.
- Studying methods for predicting off-target effects across the genome.
- Developing new genome-editing technologies and identifying their novel uses.
Selected Publications
- Young-hoon Kim, Nahye Kim, Ikenna Okafor, Sungchul Choi, Seonwoo Min, Joonsun Lee, Seung-Min Bae, Keunwoo Choi, Janice Choi, Vinayak Harihar, Youngho Kim, Jin-Soo Kim, Benjamin Kleinstiver, Jungjoon K. Lee*, Taekjip Ha*, Hyongbum Henry Kim*, Sniper2L is ahigh-fidelity Cas9 variant with high activity, Nature Chemical Biology, 2023, https://doi.org/10.1038/s41589-023-01279-5.
- Jeonghun Kwon, Minyoung Kim, Woochang Hwang, Anna Jo, Gue-Ho Hwang, Minhee Jung, Un Gi Kim, Gang Cui, Heonseok Kim, Joon-Ho Eom, Junho K. Hur, Junwon Lee, Youngho Kim, Jin-soo Kim, Sangsu Bae, Jungjoon K. Lee*, Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches, Genome Biology, 2023, 24, Article number: 4.
- Jeonghun Kwon, Minyoung Kim, Seungmin Bae, Anna Jo, Youngho Kim, Jungjoon K. Lee*,TAPE-seq is a cell-based method for predicting genome-wide off-target effects of prime editor, Nature Communications, 2022, 13, Article number: 7975
- Ikenna C Okafor, Digvijay Singh, Yanbo Wang, Minhee Jung, Haobo Wang, John Mallon, Scott Bailey, Jungjoon K. Lee, Taekjip Ha*, Single molecule analysis of effects of non-canonical guide RNAs and specificity-enhancing mutations on Cas9-induced DNA unwinding, Nucleic Acids Res. 2019 Dec 16; 47(22): 11880–11888
- Jungjoon K. Lee*, Euihwan Jeong, Joonsun Lee, Minhee Jung, Eunji Shin, Young-hoon Kim,Kangin Lee, Inyoung Jung, Daesik Kim, Seokjoong Kim & Jin-Soo Kim*, Directed evolution ofCRISPR-Cas9 to increase its specificity, Nature Communications, 2018; 9, Article number: 3048.