HAN Weiping

Honorary Joint Professor
HAN Weiping

Affiliations

Division Director, Neurometabolism in Health & Diseases, Institute of Molecular and Cell Biology, A*STAR
Professor, Cardiovascular and Metabolic Disorders, Duke-NUS Medical School.
Honorary Joint Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.

Education

Degree and Institution Year(s)
Nankai University, Tianjin, China 1986-1991
Cornell University, Ithaca, NY, USA 1992-1996

Professional Experience

Position and Institute Year(s)
Division Director, Institute of Molecular and Cell Biology, A*STAR 2021 – Present
Deputy Director, Singapore Bioimaging Consortium, A*STAR 2012 – 2021

Research Interest

My research aims to understand the molecular basis of diabetes and its complications, to discover and validate targets for drug development, and to develop animal models for evaluation of therapeutic interventions. My lab uses molecular genetics, cell biology, and physiology techniques to analyze genetically modified animals and cell lines. The current major research topics are:

  • Molecular regulation of neurohormonal communication and action
  • Translational efforts using animal models of human diseases
  • Metabolic diseases as a risk factor for cancer and dementia

 

Selected Publications

  1. So WY, Liu WN, Teo AKK, Rutter GA, Han W. Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. Sci Transl Med. 2021 Jun 30;13(600):eabb1038. doi: 10.1126/scitranslmed.abb1038. PMID: 34193609.
  2. Tan HYA, Sim MFM, Tan SX, Ng Y, Gan SY, Li H, Neo SP, Gunaratne J, Xu F, Han W. HOXC10 Suppresses Browning to Maintain White Adipocyte Identity. Diabetes. 2021 Aug;70(8):1654-1663. doi: 10.2337/db21-0114. Epub 2021 May 14. PMID:33990396; PMCID: PMC8385616.
  3. Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Wai Ho TS, Chow P, Toh HC, Reversade B, Gruenewald S, Han W. Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. J Hepatol. 2020 Apr;72(4):725-735. doi:10.1016/j.jhep.2019.10.026. Epub 2019 Nov 11. PMID: 31726117.
  4. Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W: Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression. Cell Metabolism 29(5):1151-1165, 2019 (May 7, 2019).
  5. Chen N, Sugihara H, Kim J, Fu Z, Barak B, Sur M, Feng G*, Han W*: Direct modulation of GFAP-expressing glia in the Arcuate nucleus bi-directionally regulates feeding. E-Life 5:e18716, October 18, 2016.
  6. Wu B, Wei S, Petersen N, Ali Y, Wang X, Rorsman P, Hong W, Südhof TC*, Han W*: Synaptotagmin-7 is a GLP-1 effector in its potentiation of glucose-stimulated insulin secretion. Proceedings of the National Academy of Sciences of the United States of America 112(32):9996-10001, 2015.
  7. Lim CY, Bi X, Wu D, Kim JB, Gunning PW, Hong W, Han W: Tropomodulin 3 is a novel Akt2 effector regulating GLUT4 exocytosis. Nature Communications 6:5951 doi: 10.1038/ncomms6951, 2015.
  8. Li H, Wei S, Cheng K, Gounko NV, Ericksen RE, Xu A, Hong W*, Han W*: BIG3 inhibits insulin granule biogenesis and insulin secretion. The EMBO Reports 15(6):714-722, 2014.
  9. Gustavsson N, Wei S-H, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W: Synaptotagmin-7 is a principal Ca2+-sensor for Ca2+-induced glucagon exocytosis in pancreas. The Journal of Physiology 587(6):1169-1178, 2009.
  10. Gustavsson N, Lao Y, Maximov A, Chuang J-C, Kostromina E, Repa J, Li C, Radda GK, Südhof TC*, Han W*: Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proceedings of the National Academy of Sciences of the United States of America105:3992-3997, 2008.
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