Tan May Chin, Theresa

Associate Professor
Tan May Chin, Theresa

Affiliations

Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS.
Assistant Dean (Academic Affairs), Yong Loo Lin School of Medicine, NUS.

Research Interest

* Sequence-specific strategies for inhibition of Hepatitis B viral gene expression.
* Role of microRNAs in liver diseases.
* Regulation of expression of sulfotransferases (SULTs).
* Regulation of expression of the multidrug resistance protein (MRP/ABCC) subfamily of transporters.

Selected Publications

  1. Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG, Tan TM. Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma. Cancer Sci. 2009 Jul;100(7):1234-42.
  2. Tan EL, Tan TM, Chow V, Poh CL. Inhibition of enterovirus 71 in virus-infected mice by RNA interference. Mol Ther. 2007 Nov;15(11):1931-8.
  3. TMC Tan, Yang F, Fu H, Raghavendra MS and Lam Y. (2007) Traceless Solid-Phase Synthesis and Biological Evaluation of Purine Analogs as Inhibitors of Multidrug Resistance Protein 4. Journal of Combinatorial Chemistry, 9: 210-218.
  4. TMC Tan, Chen Y, Kong KH, Bai J, Li Y, Lim SG, Ang TH and Lam Y. (2006) Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1,3,4]-oxadiazoles as potential anti-hepatitis B virus agents. Antiviral Res. 71(1):7-14.
  5. Bai J, Lai L, Yeo H, Goh B and Tan TMC. (2004) Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int. J. Biochem. Cell Biol. 36(2): 247-257.
  6. Yang S, Tan TMC, Wee A and Leow CK. (2004) Mitochondrial respiratory function and antioxidant capacity in normal and cirrhotic livers following partial hepatectomy. Cell Mol. Life Sci. 61(2): 220-229.
  7. Li Y, Wasser S, Lim SG and TMC Tan. (2004) Genome-wide expression profiling of RNA interference of hepatitis B virus replication. Cell Mol. Life Sci. 61(16): 2113-2124.
  8. Lai L and Tan TMC. (2002) Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4) mediated efflux of cAMP and resistance to purine analogs. Biochem. J. 361: 497-503.
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