Phoenix Laboratory of Gene Therapy and Cell Therapy

Publications

  1. Sia KC, Fu ZY, Mohd Rodhi SH, Yee JHY, Qu K, Gan SU. Efficient AAV9 Purification Using a Single-Step AAV9 Magnetic Affinity Beads Isolation. Int J Mol Sci. 2024 Jul 30;25(15):8342. doi: 10.3390/ijms25158342. PMID: 39125910; PMCID: PMC11313462.
  2. Liu J, Sun B, Li W, Kim HJ, Gan SU, Ho JS, Rahmat JNB, Zhang Y. Wireless sequential dual light delivery for programmed PDT in vivo. Light Sci Appl. 2024 May 15;13(1):113. doi: 10.1038/s41377-024-01437-x. PMID: 38744817; PMCID: PMC11094163.
  3. Sia KC, Gan SU, Mohd Rodhi SH, Fu ZY, Kopchick JJ, Waters MJ, Lee KO. First use of gene therapy to treat growth hormone resistant dwarfism in a mouse model. Gene Ther. 2022 Feb 1. doi: 10.1038/s41434-022-00313-w. Epub ahead of print. PMID: 35105948.
  4. Lau HH, Gan SU, Lickert H, Shapiro AMJ, Lee KO, Teo AKK. Charting the next century of insulin replacement with cell and gene therapies. Med. 2021 Oct 8;2(10):1138-1162. doi: 10.1016/j.medj.2021.09.001. PMID: 35590204.
  5. Tao Z, Loo S, Su L, Tan S, Tee G, Gan SU, Zhang J, Chen X, Ye L. Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction. Cardiovasc Res. 2021 May 25;117(6):1578-1591. doi: 10.1093/cvr/cvaa215. PMID: 32666104.
  6. Sia KC, Fu ZY, Calne RY, Nathwani AC, Lee KO, Gan SU. Modification of a Constitutive to Glucose-Responsive Liver-Specific Promoter Resulted in Increased Efficacy of Adeno-Associated Virus Serotype 8-Insulin Gene Therapy of Diabetic Mice. Cells. 2020 Nov 13;9(11):2474. doi: 10.3390/cells9112474. PMID: 33202992; PMCID: PMC7696068.
  7. Wong HY, Prasad A, Gan SU, Chua JJE, Schwarz H. Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand. Front Immunol. 2020 Nov 6;11:571964. doi: 10.3389/fimmu.2020.571964. PMID: 33240262; PMCID: PMC7677239.
  8. Sriram G, Handral HK, Gan SU, Islam I, Rufaihah AJ, Cao T. Fabrication of vascularized tissue constructs under chemically defined culture conditions. Biofabrication. 2020 Jul 29;12(4):045015. doi: 10.1088/1758-5090/aba0c2. PMID: 32599575.
  9. Kong CM, Arjunan S, Gan SU, Biswas A, Bongso A, Fong CY. Tissues derived from reprogrammed Wharton's jelly stem cells of the umbilical cord as a platform to study gestational diabetes mellitus. Stem Cell Res. 2020 Jun 26;47:101880. doi: 10.1016/j.scr.2020.101880. Epub ahead of print. PMID: 32622342.
  10. Arjunan S, Gan SU, Choolani M, Raj V, Lim J, Biswas A, Bongso A, Fong CY. Inhibition of growth of Asian keloid cells with human umbilical cord Wharton's jelly stem cell-conditioned medium. Stem Cell Res Ther. 2020 Feb 21;11(1):78. doi: 10.1186/s13287-020-01609-7. PMID: 32085797; PMCID: PMC7035736.
  11. Gan, S. U., Fu, Z., Sia, K. C., Kon, O. L., Calne, R., and Lee, K. O. (2018). Development of a liver-specific Tet-Off AAV8 vector for improved safety of insulin gene therapy for diabetes. J Gene Med, e3067.
  12. Recino, A., Gan, S. U., Sia, K. C., Sawyer, Y., Trendell, J., Kay, R., Gribble, F. M., Reimann, F., Foale, R., Notaridou, M., et al. (2018). Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther.
  13. Gan, S. U., Notaridou, M., Fu, Z. Y., Lee, K. O., Sia, K. C., Nathwani, A. C., Della Peruta, M., and Calne, R. Y. (2016). Correction of murine diabetic hyperglycaemia with a single systemic administration of an AAV2/8 vector containing a novel codon optimized human insulin gene. Curr Gene Ther. 16(1), 65-72.
  14. Do, H. V., Loke, W. T., Kee, I., Liang, V., David, S. J., Gan, S. U., Lee, S. S., Ng, W. H., Koong, H. N., Ong, H. S., et al. (2015). Characterization of Insulin-Secreting Porcine Bone Marrow Stromal Cells Ex Vivo and Autologous Cell Therapy In Vivo. Cell Transplant 24, 1205-1220.
  15. Calne, R. Y., Ghoneim, M. A., Lee, K. O., and Uin, G. S. (2013). Gene and stem cell therapy for diabetes. Clin Transpl, 111-112.
  16. Gabr, M. M., Zakaria, M. M., Refaie, A. F., Ismail, A. M., Abou-El-Mahasen, M. A., Ashamallah, S. A., Khater, S. M., El-Halawani, S. M., Ibrahim, R. Y., Uin, G. S., et al. (2013). Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice. Cell Transplant 22, 133-145.
  17. Lee, K. O., Gan, S. U., and Calne, R. Y. (2012). Stem cell therapy for diabetes. Indian J Endocrinol Metab 16, S227-229.
  18. Calne, R. Y., Gan, S. U., and Lee, K. O. (2010). Stem cell and gene therapies for diabetes mellitus. Nat Rev Endocrinol 6, 173-177.
  19. Gan, S. U., and Calne, R. Y. (2006). Gene therapy for hemophilia A. Discov Med 6, 198-202.
  20. Gan, S. U., Kon, O. L., and Calne, R. Y. (2006). Genetic engineering for haemophilia A. Expert Opin Biol Ther 6, 1023-1030.