{"id":757,"date":"2023-04-04T20:32:18","date_gmt":"2023-04-04T12:32:18","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/?page_id=757"},"modified":"2023-04-10T13:15:08","modified_gmt":"2023-04-10T05:15:08","slug":"stem-cell-technologies-and-diabetes","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/area-of-research\/functional-genomics\/stem-cell-technologies-and-diabetes\/","title":{"rendered":"Stem Cell Technologies and Diabetes"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"757\" class=\"elementor elementor-757\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-489b2a3 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"489b2a3\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ac53e8b\" data-id=\"ac53e8b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2f93999 elementor-widget elementor-widget-heading\" data-id=\"2f93999\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Areas of Research<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section 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elementor-top-section elementor-element elementor-element-89c804d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89c804d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8113657\" data-id=\"8113657\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cc8b37 elementor-align-right elementor-widget elementor-widget-button\" data-id=\"3cc8b37\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"btn-trigger\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Expand All<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8057f1 elementor-widget elementor-widget-html\" data-id=\"e8057f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\r\n    jQuery(\"#btn-trigger\").click(function(){\r\n   jQuery(\".elementor-toggle-item .elementor-tab-title\").click();\r\n   \r\n   var text = jQuery(\"#btn-trigger .elementor-button-text\").html();\r\n   \r\n   if( text == 'Expand All'){\r\n       jQuery(\"#btn-trigger .elementor-button-text\").html('Collapse All');\r\n   }\r\n   else{\r\n       jQuery(\"#btn-trigger .elementor-button-text\").html('Expand All');\r\n   }\r\n   \r\n   return false;\r\n});\r\n    \r\n<\/script>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4af3fc my-accordian elementor-widget elementor-widget-toggle\" data-id=\"d4af3fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"toggle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle\">\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2231\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2231\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Modelling & Studying Human Diabetes Disease Mechanisms <\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2231\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2231\"><p>hPSCs that comprise of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) derived from patients with monogenic, gestational, type 1 or type 2 diabetes patients will be differentiated into human pancreatic cells or cell types affected in diabetic complications to dissect the pathology of diabetes and its complications (Figure 1). This effort will also contribute directly to the understanding of human potential and development.<\/p><figure id=\"attachment_1073\" aria-describedby=\"caption-attachment-1073\" style=\"width: 1330px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1073 size-full\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/01_Figure-1_Differentiation-of-hiPSCs.png\" alt=\"\" width=\"1330\" height=\"498\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/01_Figure-1_Differentiation-of-hiPSCs.png 1330w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/01_Figure-1_Differentiation-of-hiPSCs-300x112.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/01_Figure-1_Differentiation-of-hiPSCs-1024x383.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/01_Figure-1_Differentiation-of-hiPSCs-768x288.png 768w\" sizes=\"(max-width: 1330px) 100vw, 1330px\" \/><figcaption id=\"caption-attachment-1073\" class=\"wp-caption-text\">Figure 1: Differentiation of hiPSCs derived from diabetic patients into various cell types for\u00a0in vitro\u00a0disease modelling of diabetes and its complications (Teo et al., Cell Metab, 2013)<\/figcaption><\/figure><p>\u00a0<\/p><p>The process of differentiating hPSCs into pancreatic \u03b2-like cells will be used to study human \u03b2 cell development, maturation and function. This will identify critical steps, key pathways and mechanisms which guide human \u03b2 cell development and maturation (Figure 2).\u00a0<\/p><figure id=\"attachment_1074\" aria-describedby=\"caption-attachment-1074\" style=\"width: 1330px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1074 size-full\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/02_Pivotal-Stages-of-Pancreatic-Differentiation.png\" alt=\"\" width=\"1330\" height=\"1040\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/02_Pivotal-Stages-of-Pancreatic-Differentiation.png 1330w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/02_Pivotal-Stages-of-Pancreatic-Differentiation-300x235.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/02_Pivotal-Stages-of-Pancreatic-Differentiation-1024x801.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/02_Pivotal-Stages-of-Pancreatic-Differentiation-768x601.png 768w\" sizes=\"(max-width: 1330px) 100vw, 1330px\" \/><figcaption id=\"caption-attachment-1074\" class=\"wp-caption-text\">Figure 2. Differentiation of hPSCs into pancreatic \u03b2-like cells based on knowledge from mammalian pancreas development (Santosa et al., Front Endo, 2016).<\/figcaption><\/figure><p>\u00a0<\/p><p>Differentiating hiPSCs from diabetic patients with and without complications, such as diabetic nephropathy, will elucidate genetic and epigenetic perturbations which occur in cells\/tissues\/organs constantly exposed to hyperglycaemia.<\/p><figure id=\"attachment_1075\" aria-describedby=\"caption-attachment-1075\" style=\"width: 1330px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1075 size-full\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/03_Uses-of-hiPSC-derived-pancreatic-\u03b2-like-cells.png\" alt=\"\" width=\"1330\" height=\"966\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/03_Uses-of-hiPSC-derived-pancreatic-\u03b2-like-cells.png 1330w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/03_Uses-of-hiPSC-derived-pancreatic-\u03b2-like-cells-300x218.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/03_Uses-of-hiPSC-derived-pancreatic-\u03b2-like-cells-1024x744.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/03_Uses-of-hiPSC-derived-pancreatic-\u03b2-like-cells-768x558.png 768w\" sizes=\"(max-width: 1330px) 100vw, 1330px\" \/><figcaption id=\"caption-attachment-1075\" class=\"wp-caption-text\">Figure 3. The use of hiPSC-derived pancreatic \u03b2-like cells for diabetes disease modelling, drug screening and development of therapeutics using newer technologies (Amirruddin and Low et al., Sem Cell Dev Biol, 2019).<\/figcaption><\/figure><p>\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2232\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2232\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Developing New Therapeutics to Improve Pancreatic \u03b2-cell Function<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2232\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2232\"><p>Patient-specific hiPSCs with clinical deficiencies in insulin secretion, such as that of MODY1 and MODY3 (Figure 4), will be used to identify new targets and pathways relating to insulin secretion mechanisms.\u000b<br \/>Novel biological and natural products will also be tested on human islets and human \u03b2 cells with the goal of identifying new molecules or signalling pathways that can regulate \u03b2 cell insulin secretion capacity.<\/p><figure id=\"attachment_1092\" aria-describedby=\"caption-attachment-1092\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1092 size-large\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture4-1024x590.png\" alt=\"\" width=\"800\" height=\"461\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture4-1024x590.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture4-300x173.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture4-768x442.png 768w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture4.png 1330w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-1092\" class=\"wp-caption-text\">\u200bFigure 4. Hepatocyte nuclear factors (HNFs) such as HNF4A\/MODY1 and HNF1A\/MODY3 are involved in a regulatory network in the pancreas (Lau et al., J Hepatol, 2018). Mutations in these pancreatic transcription factors result in defective insulin secretion in MODY patients.<\/figcaption><\/figure><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-toggle-item\">\n\t\t\t\t\t<div id=\"elementor-tab-title-2233\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2233\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon elementor-toggle-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-closed\"><i class=\"fas fa-chevron-down\"><\/i><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-toggle-icon-opened\"><i class=\"elementor-toggle-icon-opened fas fa-chevron-up\"><\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-toggle-title\" tabindex=\"0\">Developing Stem-Based Therapies for the Treatment of Diabetes<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div id=\"elementor-tab-content-2233\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2233\"><p>Human stem cells are highly renewable and non-xenogenic. Therefore, they can be appropriately positioned for cell therapy in diabetes patients. Current Good Manufacturing Practice (cGMP) hPSC-derived \u03b2 cells can potentially be used for islet cell replacement therapy in diabetes patients. Multipotent mesenchymal stromal cells (MSCs) can also be used to confer beneficial immunomodulatory properties upon transplanted human islets or \u03b2 cells to improve the long-term success of cell replacement therapy. Last but not least, bioengineering efforts including the development of encapsulation devices or the use of scaffolds will complement these stem cell-based development efforts. Together, it is envisioned that the production of sufficient mature and functional human \u03b2 cells from hPSCs for cell replacement therapy will achieve physiological control of blood glucose levels, to provide a better life for diabetes patients.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-1096 size-large\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture5-1024x887.png\" alt=\"\" width=\"800\" height=\"693\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture5-1024x887.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture5-300x260.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture5-768x665.png 768w, https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/wp-content\/uploads\/sites\/11\/2023\/04\/Picture5.png 1330w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1b6e78 elementor-widget elementor-widget-spacer\" data-id=\"b1b6e78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c142198 elementor-widget elementor-widget-button\" data-id=\"c142198\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/area-of-research\/functional-genomics\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"25.414\" height=\"16.828\" viewBox=\"0 0 25.414 16.828\"><g id=\"arrow\" transform=\"translate(432.914 1.414)\"><line id=\"Line_115\" data-name=\"Line 115\" x1=\"7\" y2=\"7\" transform=\"translate(-431.5)\" fill=\"none\" stroke=\"#ee6c4d\" stroke-linecap=\"square\" stroke-width=\"2\"><\/line><line id=\"Line_116\" data-name=\"Line 116\" x2=\"7\" y2=\"7\" transform=\"translate(-431.5 7)\" fill=\"none\" stroke=\"#ee6c4d\" stroke-linecap=\"square\" stroke-width=\"2\"><\/line><line id=\"Line_117\" data-name=\"Line 117\" x2=\"22.5\" transform=\"translate(-431 7)\" fill=\"none\" stroke=\"#ee6c4d\" stroke-linecap=\"square\" stroke-width=\"2\"><\/line><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Back to Functional Genomics<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Areas of Research Expand All Modelling &#038; Studying Human Diabetes Disease Mechanisms hPSCs that comprise of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) derived from patients with monogenic, gestational, type 1 or type 2 diabetes patients will be differentiated into human pancreatic cells or cell types affected in diabetic complications [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":744,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-757","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Stem Cell Technologies and Diabetes - Precision Medicine<\/title>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stem Cell Technologies and Diabetes - Precision Medicine\" \/>\n<meta property=\"og:description\" content=\"Areas of Research Expand All Modelling &#038; Studying Human Diabetes Disease Mechanisms hPSCs that comprise of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) derived from patients with monogenic, gestational, type 1 or type 2 diabetes patients will be differentiated into human pancreatic cells or cell types affected in diabetic complications [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/precision-medicine\/area-of-research\/functional-genomics\/stem-cell-technologies-and-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Precision Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-10T05:15:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/wp-content\/uploads\/sites\/11\/2023\/04\/stemcell-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/\",\"name\":\"Stem Cell Technologies and Diabetes - Precision Medicine\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/wp-content\\\/uploads\\\/sites\\\/11\\\/2023\\\/04\\\/stemcell-1.png\",\"datePublished\":\"2023-04-04T12:32:18+00:00\",\"dateModified\":\"2023-04-10T05:15:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/#primaryimage\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/wp-content\\\/uploads\\\/sites\\\/11\\\/2023\\\/04\\\/stemcell-1.png\",\"contentUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/wp-content\\\/uploads\\\/sites\\\/11\\\/2023\\\/04\\\/stemcell-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/stem-cell-technologies-and-diabetes\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Areas of Research\",\"item\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Functional Genomics\",\"item\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/area-of-research\\\/functional-genomics\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Stem Cell Technologies and Diabetes\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/#website\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/\",\"name\":\"Precision Medicine\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/precision-medicine\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Stem Cell Technologies and Diabetes - Precision Medicine","og_locale":"en_US","og_type":"article","og_title":"Stem Cell Technologies and Diabetes - Precision Medicine","og_description":"Areas of Research Expand All Modelling &#038; 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