{"id":2025,"date":"2022-03-30T12:02:08","date_gmt":"2022-03-30T04:02:08","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/n2cr\/?page_id=2025"},"modified":"2025-10-03T16:07:16","modified_gmt":"2025-10-03T08:07:16","slug":"early-cancer-intervention","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/n2cr\/research-themes\/early-cancer-intervention\/","title":{"rendered":"Early Cancer Intervention"},"content":{"rendered":"\t\t
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Research Theme<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Tissue-Specific Carcinogenesis<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Precision Cancer Medicine<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Early Cancer Intervention<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tEarly Cancer Intervention (ECI) focuses on understanding how cell autonomous and non-cell autonomous changes contribute to cancer initiation and relapse post-treatment with the goal of developing innovative approaches to delay, prevent or treat cancer at its earliest stages. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tJoin us as a Member<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Theme Leads<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof Ashok VENKITARAMAN<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Theme Lead<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tResearch focus is on deciphering the mechanisms underlying cancer susceptibility to intercept cancer evolution.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof Polly CHEN<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Theme Lead<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\tResearch focus is on identifying how the harmful changes that occur in RNA molecules trigger a cell to develop into cancer which can eventually lead to the unsatisfactory treatment outcomes for patients with cancers. The long-term goal of Dr Chen\u2019s team is to develop novel cancer therapies targeting these cancer-associated RNA changes.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Theme Members - Primary<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof CHEN Ee Sin<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof CHEN Zhi Xiong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tNeuroblastoma is the leading cause of cancer death in children. Our research is to develop improved approaches for treating neuroblastoma through drug repurposing and predicting outcome in paediatric tumours through blood sample monitoring.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof Peter GOON<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on novel work identification of promising biomarkers in early diagnosis of pre-cancer and early cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof Mikael HARTMAN<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus on epidemiology and breast cancer. Currently working on the development of artificial intelligence for breast cancer detection.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Anthony KHONG<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The Khong lab aspires to describe how biomolecular condensates participate in cancer biology with the goal of developing cancer therapeutics<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof LEE Soo Chin<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focuses on novel therapeutics and predictive biomarkers in breast cancer. Her team has identified a biomarker detectable in blood that predicts breast cancer recurrence, and that can be used to select patients for a novel targeted therapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Jason PITT<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on generating and applying computational methods to understand the causes and consequences of genomic instability in cancer. Additionally, we develop innovative genomic data democratization platforms to enhance scientific discovery as well as precision oncology.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Elayanambi SUNDARAMOORTHY<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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My research investigates whether metabolic dysregulation could be a driver for early carcinogenesis, whether physiological triggers of metabolic stress can drive cancer initiation and also metabolism driven carcinogenesis in breast cancers, specially in cancers associated with BRCA2.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof SO Bok Yan, Jimmy<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is to improve outcomes of patients with gastric or esophageal cancer through early detection, better understanding of their origins and novel treatment.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof TAM Kit Chung, John<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof TAM Wai Leong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr TAN Kar Tong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on developing innovative computational and genomic techniques that push the sensitivity limits of cancer detection, and that uncovers cancer-driving alterations in repetitive genomic regions.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof TAN Ker Kan<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof TAY Mei Sian, Yvonne<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focuses on understanding the role of non-coding RNAs that play a part in cancer development and exploring their potential utility as diagnostic biomarkers and targeted therapeutics for precision medicine.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof John WONG<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on medical oncology \/ hematology, particularly in breast and prostate cancer.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr ZHOU Yilong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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RNA is continuously transcribed, processed, exported, translated, and degraded within cells, a dynamic process shaped by various RNA-binding proteins, membrane organelles, and biomolecular condensates\u2014like a river shaped by rocks, banks, and lakes. Our lab investigates the dynamics of RNA flux, focusing on understanding RNA-Protein interactions and phase separation, RNA modifications and splicing changes under stress and disease conditions. We aim to uncover RNA-related disease mechanisms and identify therapeutic RNA targets. Our approach spans molecular to animal models, integrating advanced technologies such as deep sequencing, mass spectrometry, phase separation assays, iCLIP, and our self-developed “FANCI” method.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof John WONG<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on medical oncology \/ hematology, particularly in breast and prostate cancer.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr ZHOU Yilong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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RNA is continuously transcribed, processed, exported, translated, and degraded within cells, a dynamic process shaped by various RNA-binding proteins, membrane organelles, and biomolecular condensates\u2014like a river shaped by rocks, banks, and lakes. Our lab investigates the dynamics of RNA flux, focusing on understanding RNA-Protein interactions and phase separation, RNA modifications and splicing changes under stress and disease conditions. We aim to uncover RNA-related disease mechanisms and identify therapeutic RNA targets. Our approach spans molecular to animal models, integrating advanced technologies such as deep sequencing, mass spectrometry, phase separation assays, iCLIP, and our self-developed “FANCI” method.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Secondary and Adjunct Members<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

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