{"id":1792,"date":"2022-03-29T19:56:29","date_gmt":"2022-03-29T11:56:29","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/n2cr\/?page_id=1792"},"modified":"2025-07-29T14:14:41","modified_gmt":"2025-07-29T06:14:41","slug":"precision-cancer-medicine","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/n2cr\/research-themes\/precision-cancer-medicine\/","title":{"rendered":"Precision Cancer Medicine"},"content":{"rendered":"\t\t
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Research Theme<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Tissue-Specific Carcinogenesis<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Precision Cancer Medicine<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Early Cancer Intervention<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Precision Cancer Medicine (PCM) aims to make diagnosis of cancer simpler and more accurate and ultimately improve treatment. The PCM theme aims to focus research that will identify effective biomarkers, develop new treatment modalities for precision and personalised cancer therapy and create enabling technologies for accurate clinical diagnosis and treatment of specific cancer subtypes and individual cancer patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tJoin us as a Member<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Theme Leads<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof CHOW Kai-Hua, Edward<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on how to quickly and accurately identify effective cancer therapeutic options for individual cancer patients as well as specific sub-groups of cancer patients in both blood cancers and solid tumours.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof Glenn Kunnath BONNEY<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Theme Members - Primary<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Shruti BHATT<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The central focus of research is to identify treatment strategies and underlying mechanisms of therapy-resistant myeloid tumors by studying clonal evolutionary path and cell death mechanisms, particularly the mitochondrial pathway of apoptosis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof Dario CAMPANA<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on the development of innovative technologies to treat cancer with immune cells, and their translation into first-in human clinical trials.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr CHEONG Jit Kong<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on\u00a0<\/span>uncovering and characterising novel signalling nodes of oncogenic RAS-driven human cancers to facilitate the development of tractable therapeutic modalities.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof CHEW Suk Peng, Valerie<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research delves into deciphering the intricate immune landscape and crosstalk within the tumor microenvironment of hepatocellular carcinoma (HCC), with a keen focus on uncovering biomarkers and therapeutic avenues.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof CHNG Wee Joo<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on blood cancers to understand how the disease develops and find better ways to treat them.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr ENG Wee Ling, Gracie<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research interest focuses on the role of miRNAs as a biomarker for diagnosis and prognosis, and as a potential therapeutic biomolecule in a variety of diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Prof Marco FOIANI<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Focus of research is on cellular pathways which maintain genomic integrity in response to intrinsic topological stress, due to conflicts between replication and transcription, or extrinsic mechanical stress exerted by cytoskeletal or extracellular matrix forces. Recently, focus is on connections between cell metabolism & genome integrity pathways and between chromosome dynamics & mechano-transduction circuits controlling cell and nuclear plasticity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof Alfredo FRANCO-OBREGON <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tI approach tissue engineering, regeneration and development from a biophysical perspective, as an alternative to conventional pharmacological interventions. I am particularly interested in how mechanical and electromagnetic forces drive development and can be used to control disease. My areas of interest are skeletal muscle development, cancer and stem cell biology. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Anand Devaprasath JEYASEKHARAN <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Dennis KAPPEI<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof KHONG Pek-Lan<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Alan Prem KUMAR<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on uncovering new cues that drive the spread of cancer and develop target-based precision therapies to prevent metastasis in several types of female reproductive cancers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Shawn LEE Hsien Ren <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research interests lies in pharmacogenomics and immunogenomics in childhood leukemia; translating these precision modalities into greater personalised therapy to reduce toxicities and improve outcomes in acute leukemias.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Yang LI<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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My research focuses on the computational modeling of protein and nucleic acid structures using deep learning. I develop algorithms that integrate co-evolutionary information and deep geometric learning models to improve the accuracy of structure prediction. My work includes methods for RNA tertiary structure modeling from sequence, as well as protein complex structure prediction. I am also interested in applying these models to support RNA- and protein-targeted macromolecular sequence and structure design.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr LIM Si Jing, Joline<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr Jun Siong LOW<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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T and B cells are components of the immune system that are essential in fighting against infection-causing \u201cforeign\u201d pathogens, but are also involved in disease settings like cancer and autoimmunity where they can attack \u201cself\u201d. Our lab aims to understand the complex biology of T and B cells at the interplay of infection and cancer, by focusing on their phenotypic and functional profiles, antigen specificities and receptor repertoires. Our long-term goal is to develop rational and effective immune-based therapies to leverage on the immune system to fight cancer.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Vincent NGA<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus on advancing precision medicine and translational therapies for brain tumours, particularly gliomas and glioblastoma multiforme. I lead and collaborate on clinical trials exploring novel therapeutics, stem cell-based approaches, and biomarker-driven strategies. My work spans from molecular mechanisms of tumour stemness to innovations in neurosurgical technology and quality-of-life tools. Committed to bridging bench-to-bedside gaps and advancing brain tumour care through innovative science, translational research, and patient-centred clinical trials<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr NGOI Yan Li, Natalie<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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I am a Medical Oncologist with a keen interest in early drug development and personalized cancer medicine. My research areas of interest surround novel targets, synthetic lethal strategies and associated biomarker discovery for the treatment of Gynecologic Cancers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr OOI Gaik Ming, Melissa<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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She is currently the leukaemia group lead in National University Cancer Institute of Singapore and is also heavily involved in myeloma, leukaemia and myelodysplasia clinical care and research. She is also interested in health service research and geriatric research.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof Gautam SETHI<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is to elucidate the mechanism(s) of activation of oncogenic transcription factors and identification of novel inhibitors of these proteins for cancer prevention as well as therapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr SOON Yu Yang<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focuses on evidence synthesis and clinical trials. Research goal is to improve health outcomes by synthesizing evidence to evaluate various health interventions to guide clinical practice and inform health policy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Sriram SRIDHARAN<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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My research focus is to study how DNA replication is a source of genome instability. I aim to understand why and how the (epi)genome acts as an impediment to faithful DNA replication.\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr Supriya SRIVASTAVA\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Pathologist with a specific focus on solid cancers, particularly gastrointestinal cancers. Research focuses on the identification and validation of biomarkers that aid in the early diagnosis of gastric cancers as well as metaplastic lesions of stomach, that are considered preneoplastic and could be targeted at an early stage thereby improving the patient outcome.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr TAI Yee Kit Alex<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on integrating non-invasive pulsed electromagnetic fields as a complement to conventional chemotherapy to improve treatment outcomes and the quality of life in patients.<\/span><\/p>

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Dr TAN Char Loo<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on brain and spinal cord tumours. Besides routine clinical diagnosis, she is also interested in neurooncology-related research.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr TAY Kah Ping, Andy<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The research focus of the Tay lab is tissue-specific drug delivery and immunotherapeutics against cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr TAY Kai Xun, Joshua<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research interest is in developing gene signatures for precision medicine with full-transcriptome RNA-Seq from small amounts of FFPE tissue.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof TOO Heng-Phon <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on developing diagnostic tools to detect early changes in the development of cancers using small amounts of blood. We are now focusing on gene engineering of cells for treatment of cancers and other diseases.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof Raymond TSANG <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on the detection and surgical treatment of nasopharyngeal carcinoma,
the swallowing function of patients after head and neck cancer treatment & robotic surgery in head and neck particularly the nasopharynx and skull base.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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A\/Prof Balamurugan A VELLAYAPPAN<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on the use of advanced radiation technology, such as stereotactic ablative radiotherapy (SABR\/SBRT) and stereotactic radiosurgery, in the context of neuro-oncology and oligo-metastatic disease. Also interested in the use of novel imaging techniques (such as functional imaging, MR and artificial intelligence) to improve the delivery of radiation\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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A\/Prof WANG Lingzhi <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on oncology drug development\/evaluation pipeline that combines cell biology, pharmacological science, and pharmacokinetic analysis. Another important area of research is the discovery of non-invasive biomarkers for early detection of cancer in high-risk populations.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof YEOH Eng Juh, Allen<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tResearch focus is on improving Acute Lymphoblastic Leukaemia treatment in children and adults by better prediction of each patient\u2019s risk of relapse using highly sensitive biomarkers like RNA-Seq and MRD measurements. A\/Prof Yeoh works on immune cell therapy especially CAR-T cell therapy for leukaemia with Prof Dario Campana in NUSMed.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dr YONG Wei Peng<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof Yang ZHANG<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on cutting-edge artificial intelligence (AI) and deep-learning techniques, we are developing new methods for protein and RNA structure prediction and protein designs. We are particularly interested in the application of the AI-based computational methods for effective cancer therapeutics, with focuses on anti-cancer peptide-drug conjugates (PDCs) and T-cell receptor (TCR)-based adoptive therapy.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr ZHOU Jianbiao<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on the drug resistance mechanisms and aggressive phenotypes in hematologic malignancies, as well as the development predictive markers, novel therapeutic targets.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Dr ZHOU Jianbiao<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Research focus is on the drug resistance mechanisms and aggressive phenotypes in hematologic malignancies, as well as the development predictive markers, novel therapeutic targets.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tSEE MORE<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Secondary and Adjunct Members<\/a><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Research Theme Tissue-Specific Carcinogenesis Precision Cancer Medicine Early Cancer Intervention Precision Cancer Medicine (PCM) aims to make diagnosis of cancer simpler and more accurate and ultimately improve treatment. 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