{"id":7627,"date":"2025-09-22T14:33:08","date_gmt":"2025-09-22T06:33:08","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/?post_type=events&p=7627"},"modified":"2025-09-22T17:42:07","modified_gmt":"2025-09-22T09:42:07","slug":"mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex","status":"publish","type":"events","link":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/","title":{"rendered":"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex"},"content":{"rendered":"

Abstract:\u00a0\u00a0<\/b><\/p>\n

Bacterial cell division requires precise remodeling of the peptidoglycan layer at the septum. The conserved ATP-binding cassette transporter\u2013like complex FtsEX has emerged as a key regulator of this process, coupling ATP hydrolysis to activation of periplasmic hydrolases. In this talk, I will present recent cryo-EM structures of FtsEX and its associated factors, combined with biochemical and functional assays, to illustrate how FtsEX orchestrates septal peptidoglycan hydrolysis in different bacterial species. These findings provide a unifying mechanistic framework for how FtsEX coordinates cell wall remodeling with cytokinesis, and highlight its potential as a target for antibacterial strategies.<\/p>\n

 <\/p>\n

Recommended Readings:\u00a0\u00a0<\/b><\/p>\n

    \n
  1. Li J.W., He Y.T., Xu X., Alcorlo M., Shi J., Roper D.I., Hermoso J., Sham L.T., Luo M. Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division. eLife, 2024.<\/li>\n
  2. Li J., Xu X., Shi J., Hermoso J., Sham L.T., and Luo M. Regulation of the Cell Division Hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Nature Communications, 2023.<\/li>\n
  3. Xu, X.; Li, J.; Chua, W. Z.; Pages, M. A.; Shi, J.; Hermoso, J. A.; Bernhardt, T.; Sham, L. T.; Luo, M. Mechanistic insights into the regulation of cell wall hydrolysis by FtsEX and EnvC at the bacterial division site. PNAS, 2023.<\/li>\n
  4. Alcorlo, M., Siseth M.C., Li J.W., Sham L.T., Luo M., Hermoso J.. Modulation of the lytic apparatus by the FtsEX complex within the bacterial division machinery. FEBS Letters, 2024.<\/li>\n<\/ol>\n","protected":false},"featured_media":7631,"template":"","event_type":[19],"event_mode":[22],"class_list":["post-7627","events","type-events","status-publish","has-post-thumbnail","hentry","event_type-seminars","event_mode-on-site"],"acf":[],"yoast_head":"\nMechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme<\/title>\n<meta name=\"description\" content=\"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme\" \/>\n<meta property=\"og:description\" content=\"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/\" \/>\n<meta property=\"og:site_name\" content=\"Infectious Diseases Translational Research Programme\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-22T09:42:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-content\/uploads\/sites\/7\/2025\/09\/Dr-Luo-Min.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"720\" \/>\n\t<meta property=\"og:image:height\" content=\"1040\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/\",\"name\":\"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2025\\\/09\\\/Dr-Luo-Min.jpg\",\"datePublished\":\"2025-09-22T06:33:08+00:00\",\"dateModified\":\"2025-09-22T09:42:07+00:00\",\"description\":\"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/#primaryimage\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2025\\\/09\\\/Dr-Luo-Min.jpg\",\"contentUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/wp-content\\\/uploads\\\/sites\\\/7\\\/2025\\\/09\\\/Dr-Luo-Min.jpg\",\"width\":720,\"height\":1040},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/news\\\/seminar-courses-workshops\\\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/#website\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/\",\"name\":\"Infectious Diseases Translational Research Programme\",\"description\":\"Infectious Diseases Translational Research Programme\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/trp\\\/infectious-diseases\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme","description":"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang","og_locale":"en_US","og_type":"article","og_title":"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme","og_description":"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang","og_url":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/","og_site_name":"Infectious Diseases Translational Research Programme","article_modified_time":"2025-09-22T09:42:07+00:00","og_image":[{"width":720,"height":1040,"url":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-content\/uploads\/sites\/7\/2025\/09\/Dr-Luo-Min.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/","url":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/","name":"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Infectious Diseases Translational Research Programme","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/#website"},"primaryImageOfPage":{"@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/#primaryimage"},"image":{"@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/#primaryimage"},"thumbnailUrl":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-content\/uploads\/sites\/7\/2025\/09\/Dr-Luo-Min.jpg","datePublished":"2025-09-22T06:33:08+00:00","dateModified":"2025-09-22T09:42:07+00:00","description":"ID TRP Seminar Series: Mechanistic Insights into Cell Division Regulated by the FtsEX Complex - Assistant Professor Anni Zhang","breadcrumb":{"@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/#primaryimage","url":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-content\/uploads\/sites\/7\/2025\/09\/Dr-Luo-Min.jpg","contentUrl":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-content\/uploads\/sites\/7\/2025\/09\/Dr-Luo-Min.jpg","width":720,"height":1040},{"@type":"BreadcrumbList","@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/news\/seminar-courses-workshops\/mechanistic-insights-into-cell-division-regulated-by-the-ftsex-complex\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/"},{"@type":"ListItem","position":2,"name":"Mechanistic Insights into Cell Division Regulated by the FtsEX Complex"}]},{"@type":"WebSite","@id":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/#website","url":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/","name":"Infectious Diseases Translational Research Programme","description":"Infectious Diseases Translational Research Programme","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/events\/7627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/events"}],"about":[{"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/types\/events"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/media\/7631"}],"wp:attachment":[{"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/media?parent=7627"}],"wp:term":[{"taxonomy":"event_type","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/event_type?post=7627"},{"taxonomy":"event_mode","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/trp\/infectious-diseases\/wp-json\/wp\/v2\/event_mode?post=7627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}