{"id":1466,"date":"2023-02-06T14:10:35","date_gmt":"2023-02-06T06:10:35","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/?post_type=research-highlights&p=1466"},"modified":"2023-11-08T15:10:18","modified_gmt":"2023-11-08T07:10:18","slug":"cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance","status":"publish","type":"research-highlights","link":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/","title":{"rendered":"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance"},"content":{"rendered":"

CAR-T therapy is often very costly and not effective in killing solid tumours.<\/span><\/p>\n

Prof\u202fNicholas Gascoigne, Dr Wu Ling and team have discovered the by manipulating the signalling molecules in the CAR-T cells, the efficacy of these cells can be improved so that they have a better ability to persist in the host and to kill the tumour. This also improves the CAR-T function in a solid tumour model.<\/span>\u00a0<\/span><\/p>\n

https:\/\/www.cell.com\/cell-reports-medicine\/fulltext\/S2666-3791(23)00002-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666379123000022%3Fshowall%3Dtrue<\/span><\/a><\/p>\n","protected":false},"featured_media":2187,"template":"","research-hightlights-category":[38],"acf":[],"yoast_head":"\nCD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance - Immunology<\/title>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance - Immunology\" \/>\n<meta property=\"og:description\" content=\"CAR-T therapy is often very costly and not effective in killing solid tumours. Prof\u202fNicholas Gascoigne, Dr Wu Ling and team have discovered the by manipulating the signalling molecules in the CAR-T cells, the efficacy of these cells can be improved so that they have a better ability to persist in the host and to kill […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/\" \/>\n<meta property=\"og:site_name\" content=\"Immunology\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-08T07:10:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2023\/02\/iStock-1222035931.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1282\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/\",\"name\":\"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance - Immunology\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/#website\"},\"datePublished\":\"2023-02-06T06:10:35+00:00\",\"dateModified\":\"2023-11-08T07:10:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/cd28-car-t-cell-activation-through-fyn-kinase-signaling-rather-than-lck-enhances-therapeutic-performance\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/\",\"name\":\"Immunology\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance - Immunology","og_locale":"en_US","og_type":"article","og_title":"CD28-CAR-T cell activation through FYN kinase signaling rather than LCK enhances therapeutic performance - Immunology","og_description":"CAR-T therapy is often very costly and not effective in killing solid tumours. 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