{"id":1464,"date":"2022-11-11T14:09:32","date_gmt":"2022-11-11T06:09:32","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/?post_type=research-highlights&#038;p=1464"},"modified":"2023-11-08T15:16:46","modified_gmt":"2023-11-08T07:16:46","slug":"postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions","status":"publish","type":"research-highlights","link":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/","title":{"rendered":"Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions"},"content":{"rendered":"<p><span data-contrast=\"auto\">Multiple Sclerosis (MS) is a debilitating disease with few therapeutic options. Sphingosine-1-phosphate (S1P) is a potent lipid mediator secreted by several cell types and is involved in several important biological pathways. Assistant Prof Nguyen Nam Long collaborated with A\/Prof\u202fVeronique Angeli\u202fand A\/Prof\u202fZhang Yongliang\u202fin a study which showed the targeting of S1P transporters could be a potential therapeutic target in treating MS and other neuroinflammatory diseases.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04573-y\"><span data-contrast=\"none\">https:\/\/link.springer.com\/article\/10.1007\/s00018-022-04573-y<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n","protected":false},"featured_media":2191,"template":"","research-hightlights-category":[38],"class_list":["post-1464","research-highlights","type-research-highlights","status-publish","has-post-thumbnail","hentry","research-hightlights-category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions - Immunology<\/title>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions - Immunology\" \/>\n<meta property=\"og:description\" content=\"Multiple Sclerosis (MS) is a debilitating disease with few therapeutic options. Sphingosine-1-phosphate (S1P) is a potent lipid mediator secreted by several cell types and is involved in several important biological pathways. Assistant Prof Nguyen Nam Long collaborated with A\/Prof\u202fVeronique Angeli\u202fand A\/Prof\u202fZhang Yongliang\u202fin a study which showed the targeting of S1P transporters could be a potential [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/\" \/>\n<meta property=\"og:site_name\" content=\"Immunology\" \/>\n<meta property=\"article:modified_time\" content=\"2023-11-08T07:16:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1330728771.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1282\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/\",\"name\":\"Postnatal deletion of Spns2 prevents neuroinflammation without compromising blood vascular functions - Immunology\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1330728771.jpg\",\"datePublished\":\"2022-11-11T06:09:32+00:00\",\"dateModified\":\"2023-11-08T07:16:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/postnatal-deletion-of-spns2-prevents-neuroinflammation-without-compromising-blood-vascular-functions\/#primaryimage\",\"url\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1330728771.jpg\",\"contentUrl\":\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1330728771.jpg\",\"width\":1920,\"height\":1282,\"caption\":\"Woman scientist in lab look at science microscope medical test and research biology chemistry. 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