{"id":75,"date":"2023-08-22T12:10:53","date_gmt":"2023-08-22T04:10:53","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/?page_id=75"},"modified":"2023-11-08T14:21:03","modified_gmt":"2023-11-08T06:21:03","slug":"research-highlights","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/","title":{"rendered":"Research Highlights"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"75\" class=\"elementor elementor-75\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-00322b2 e-flex e-con-boxed e-con e-parent\" data-id=\"00322b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-634e989 e-con-full e-flex e-con e-child\" data-id=\"634e989\" 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only screen and (max-width: 600px) {\n        .filter-container {\n            flex-direction: column;\n            margin-bottom: 20px;\n        }\n\n        .inner-container-right,\n        .inner-container-left {\n            width: 100%;\n        }\n\n        .grid-container {\n            margin: 0px 0 20px 0;\n        }\n    }\n<\/style>\n<form id=\"gallery_filter_form\" method=\"get\" action=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-json\/wp\/v2\">\n    <div class=\"filter-container\">\n        <div class=\"inner-container-left\">\n            <div class=\"dropdown-container\">\n                <span>Filter By:<\/span>\n                <br>\n                <select name=\"categories\" onchange=\"SubmitForm('gallery_filter_form');\">\n                    <option value=\"\">All Research Highlights<\/option>\n                                            <option value=\"publications\" >\n                            Publications                        <\/option>\n                                            <option value=\"milestones\" >\n                            Milestones                        <\/option>\n                                            <option value=\"outcomes\" >\n                            Outcomes                        <\/option>\n                                            <option value=\"grants\" >\n                            Grants                        <\/option>\n                                    <\/select>\n            <\/div>\n        <\/div>\n\n        <div class=\"inner-container-right\">\n            <div class=\"dropdown-container\">\n                <span>Filter By:<\/span>\n                <br>\n                <select name=\"ym\" onchange=\"SubmitForm('gallery_filter_form');\">\n                    <option value=\"\">Months\/Years<\/option>\n                                            <option value=\"2025-5\" >\n                            May                            2025                        <\/option>\n                                            <option value=\"2025-2\" >\n                            February                            2025                        <\/option>\n                                            <option value=\"2025-1\" >\n                            January                            2025                        <\/option>\n                                            <option value=\"2024-12\" >\n                            December                            2024                        <\/option>\n                                            <option value=\"2024-8\" >\n                            August                            2024                        <\/option>\n                                            <option value=\"2023-6\" >\n                            June                            2023                        <\/option>\n                                            <option value=\"2023-5\" >\n                            May                            2023                        <\/option>\n                                            <option value=\"2023-2\" >\n                            February                            2023                        <\/option>\n                                            <option value=\"2022-11\" >\n                            November                            2022                        <\/option>\n                                            <option value=\"2022-8\" >\n                            August                            2022                        <\/option>\n                                    <\/select>\n            <\/div>\n\n        <\/div>\n    <\/div>\n    <input type=\"submit\" id=\"filter-submit\" \/>\n<\/form>\n\n<div class=\"uael-post-grid__inner uael-post__columns-3 uael-post__columns-tablet-2 uael-post__columns-mobile-1\">\n                        <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/digitalized-organoids-integrated-pipelinefor-high-speed-3d-analysis-of-organoidstructures-using-multilevel-segmentationand-cellular-topology\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2025\/05\/Screenshot-2025-05-15-085617.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Digitalized organoids: integrated pipelinefor high-speed 3D analysis of organoidstructures using multilevel segmentationand cellular topology                        <\/h5>\n                        <p class=\"category-name\">\n                            14 May 2025                        <\/p>\n                        <p>Organoids replicate tissue architecture and function and offer a unique opportunity to explore the i ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/digitalized-organoids-integrated-pipelinefor-high-speed-3d-analysis-of-organoidstructures-using-multilevel-segmentationand-cellular-topology\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/molecular-basis-of-spns1-mediated-lysophospholipid-transport-from-the-lysosome\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2023\/05\/iStock-1209968955.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Molecular basis of Spns1-mediated lysophospholipid transport from the lysosome                        <\/h5>\n                        <p class=\"category-name\">\n                            13 February 2025                        <\/p>\n                        <p>Many lysosomal transporters use the pH gradient to transport a diverse array of substances, thus mai ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/molecular-basis-of-spns1-mediated-lysophospholipid-transport-from-the-lysosome\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/nation-wide-surveillance-of-tick-acari-ixodidae-infestations-of-humans-in-singapore\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2025\/02\/1-s2.0-S1877959X25000056-gr2.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Nation-wide surveillance of tick (Acari: Ixodidae) infestations of humans in Singapore                        <\/h5>\n                        <p class=\"category-name\">\n                            3 February 2025                        <\/p>\n                        <p>Ticks are an increasingly important threat to public health in Southeast Asia, due to the role of ma ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/nation-wide-surveillance-of-tick-acari-ixodidae-infestations-of-humans-in-singapore\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/plasticity-of-cell-death-pathways-ensures-gsdmd-activation-during-yersinia-pseudotuberculosis-infection\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2025\/01\/DrChenKaiwen_CellsPublication-1.png') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection                        <\/h5>\n                        <p class=\"category-name\">\n                            17 January 2025                        <\/p>\n                        <p>Congratulations to Dr Chen Kaiwen and his team \u202fon their new publication! Click here for the detai ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/plasticity-of-cell-death-pathways-ensures-gsdmd-activation-during-yersinia-pseudotuberculosis-infection\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/dusp6-regulates-notch1-signalling-in-colorectal-cancer\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1330728771.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            DUSP6 regulates Notch1 signalling in colorectal cancer                        <\/h5>\n                        <p class=\"category-name\">\n                            20 December 2024                        <\/p>\n                        <p>Congratulations to A\/Prof \u202fZhang Yongliang and his team \u202fon their new publication! Click here fo ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/dusp6-regulates-notch1-signalling-in-colorectal-cancer\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/mfsd7c-functions-as-a-transporter-of-choline-at-the-blood-brain-barrier\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2022\/11\/iStock-1483940676.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            MFSD7c functions as a transporter of choline at the blood\u2013brain barrier                        <\/h5>\n                        <p class=\"category-name\">\n                            14 August 2024                        <\/p>\n                        <p>Led by Assoc Prof Nguyen Nam Long, researchers from the NUSMED Immunology TRP at NUSMedicine unexpec ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/mfsd7c-functions-as-a-transporter-of-choline-at-the-blood-brain-barrier\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/platelet-tlr7-is-essential-for-the-formation-of-platelet-neutrophil-complexes-and-low-density-neutrophils-in-lupus-nephritis\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2023\/06\/iStock-511920036.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis                        <\/h5>\n                        <p class=\"category-name\">\n                            28 June 2023                        <\/p>\n                        <p>Congratulations to Dr\u202fFrank Sen Hee TAY\u202fon his new publication! In this paper, the team found th ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/platelet-tlr7-is-essential-for-the-formation-of-platelet-neutrophil-complexes-and-low-density-neutrophils-in-lupus-nephritis\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/il12-18-21-preactivation-enhances-the-antitumor-efficacy-of-expanded-%ce%b3%ce%b4t-cells-and-overcomes-resistance-to-anti-pd-l1-treatment\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2023\/06\/iStock-909908830.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            IL12\/18\/21 Preactivation Enhances the Antitumor Efficacy of Expanded \u03b3\u03b4T Cells and Overcomes Resistance to Anti\u2013PD-L1 Treatment                        <\/h5>\n                        <p class=\"category-name\">\n                            1 June 2023                        <\/p>\n                        <p>Cancer is still the leading cause of death in Singapore according to the Ministry of Health Statisti ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/il12-18-21-preactivation-enhances-the-antitumor-efficacy-of-expanded-%ce%b3%ce%b4t-cells-and-overcomes-resistance-to-anti-pd-l1-treatment\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n                    <div class=\"uael-post-wrapper\">\n                <div class=\"grid-container\">\n                    <!-- Slides -->\n                    <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/combining-multimodal-magnetic-resonance-brain-imaging-and-machine-learning-to-unravel-neurocognitive-function-in-non-neuropsychiatric-systemic-lupus-erythematosus\/\">\n                                                                                <div class=\"grid-item\" style=\"background: url('https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/uploads\/sites\/16\/2023\/05\/iStock-1209968955.jpg') no-repeat; background-size: cover; background-position: center;\">\n                                                            <\/div>\n                    <\/a>\n                    <div class=\"info-container\">\n                        <h5>\n                            Combining Multimodal Magnetic Resonance Brain Imaging and Machine Learning to Unravel Neurocognitive Function in Non-Neuropsychiatric Systemic Lupus Erythematosus                        <\/h5>\n                        <p class=\"category-name\">\n                            16 May 2023                        <\/p>\n                        <p>Check out Dr\u202fFrank Sen Hee TAY&#8217;s latest paper on using machine learning and magnetic resonan ...<\/p>\n                        <a href=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/news-events\/research-highlights\/combining-multimodal-magnetic-resonance-brain-imaging-and-machine-learning-to-unravel-neurocognitive-function-in-non-neuropsychiatric-systemic-lupus-erythematosus\/\">\n                            <div class=\"read_more\">Read More <img decoding=\"async\" class=\"arrow-right\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/immunology\/wp-content\/themes\/nus-immunology\/images\/arrow-forward.svg\" \/><\/div>\n                        <\/a>\n                    <\/div>\n                <\/div>\n            <\/div>\n            <\/div>\n<style>\n    .navigation{\n      margin-top: 20px;\n  }\n  .navigation li a,\n.navigation li 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