Exertional hyperthermia is a key factor known to limit human endurance performance. Recent evidence suggests that the CNS may contribute, at least in part, to hyperthermia-induced fatigue. However, the exact physiological mechanisms underlying heat-induced neural perturbations and impairments remains unknown. In this study, we seek to evaluate functional brain changes in human volunteers subjected to exertional hyperthermia using a continuous fNRIS monitoring system. CNS perturbations identified will also be correlated with a host of physiological parameters (eg. heart rate, core temperature, skin temperature, gait variability, electromyography etc) to develop a data model to predict CNS alterations during exertional hypothermia. The understanding of how CNS symptoms develops during exertional hyperthermia is pivotal to our efforts in combating performance deficits during heat stress. Data attained from the continuous monitoring of CNS perturbations throughout the course of exertional hyperthermia may further augment our understanding on the predisposing factors of exertional heat stroke. If successful, insights gained would allow future design of heat mitigation strategies that are efficiently targeted for the abatement of CNS deficits during exertional hyperthermia.