{"id":1231,"date":"2022-11-29T23:01:27","date_gmt":"2022-11-29T15:01:27","guid":{"rendered":"https:\/\/www.silentfrontier.com\/trp\/healthy-longevity\/?page_id=1231"},"modified":"2023-04-25T18:32:21","modified_gmt":"2023-04-25T10:32:21","slug":"research-highlights","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/about-us\/research-highlights\/","title":{"rendered":"Research Highlights"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1231\" class=\"elementor elementor-1231\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4d58b79 elementor-section-height-min-height elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"4d58b79\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-664017c\" data-id=\"664017c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e378359 elementor-widget elementor-widget-heading\" data-id=\"e378359\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Research Highlights<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-282a395 elementor-widget elementor-widget-heading\" data-id=\"282a395\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Celebrate our achievements with us<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a2b98d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a2b98d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29258cd\" data-id=\"29258cd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eb43b35 elementor-mobile-align-left elementor-widget elementor-widget-breadcrumbs\" data-id=\"eb43b35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p id=\"breadcrumbs\"><span><span><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/\">Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0624c8f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0624c8f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e9b7e05\" data-id=\"e9b7e05\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c4848e elementor-widget elementor-widget-heading\" data-id=\"9c4848e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Research Highlights<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1aff78d elementor-widget elementor-widget-shortcode\" data-id=\"1aff78d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\"><style>\n    #filter-submit {\n        display: none;\n    }\n\n    .filter-container {\n        padding: 20px;\n        display: inline-block;\n    }\n\n    .dropdown-container select {\n        width: 250px;\n        padding: 10px 16px;\n        border-radius: 4px;\n        height: 50px;\n        font-family: \"Poppins\";\n        font-weight: 600;\n        box-shadow: 0 5px 10px #00000024;\n        border: 1px solid transparent;\n    }\n\n    @-moz-document url-prefix() {\n        option {\n            font-family: \"Poppins\" !important;\n            font-weight: 600;\n        }\n    }\n\n    option {\n        font-family: \"Poppins\" !important;\n        font-weight: 600;\n    }\n\n    .dropdown-container {\n        display: flex;\n        justify-content: center;\n        align-items: center;\n        padding: 10px 0 10px 0;\n    }\n\n    @media(max-width: 500px) {\n        .dropdown-container {\n            display: block;\n        }\n    }\n\n    select[name=\"event_mode\"],\n    select[name=\"event_type\"] {\n        width: 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onchange=\"SubmitForm('pub_filter_form');\">\n                    <option value=\"\">Select Career Category<\/option>\n                                            <option value=\"\" selected><\/option>\n                                            <option value=\"\" selected><\/option>\n                                    <\/select>\n                <input type=\"submit\" id=\"filter-submit\" \/>\n            <\/div>\n        <\/form>\n    <\/div>\n<\/center> -->\n<div class=\"container\">\n    <div class=\"row\">\n                                    <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD+) levels are hallmarks of skeletal muscle ageing and sarcopenia, but it is unclear whether these defects result from local changes or can be mediated by systemic or dietary cues. Here we report a functional link between circulating levels of the natural alkaloid trigonelline, which is structurally related [&hellip;]<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/www.nature.com\/articles\/s42255-024-00997-x#Sec1\" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Biomarkers of ageing for the identification and evaluation of longevity interventions                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker [&hellip;]<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0092867423008577\" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            The potential benefits of assessing post\u2011cardiopulmonary exercise testing (CPET) in ageing: a narrative review                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Cardiopulmonary exercise testing (CPET) is an important tool to measure the cardiopulmonary fitness of an individual and has been widely used in athletic, clinical and research settings. Most CPET focus on analyzing physiological responses during exercise. We contend that the post-CPET recovery physiological responses offer further diagnostic and prognostic information about the health of the [&he...<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/bmcsportsscimedrehabil.biomedcentral.com\/articles\/10.1186\/s13102-023-00671-x\" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Why Is Rapamycin Not a Rapalog?                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). It is also a leading candidate for targeting aging. Rapamycin and its analogs (everolimus, temsirolimus, ridaforolimus) inhibit the mammalian target of rapamycin (mTOR) kinase by binding to FK506-binding proteins (FKBP) and have a similar chemical structure that only differs in the [&hellip;]<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/karger.com\/ger\/article\/doi\/10.1159\/000528985\/836027\/Why-Is-Rapamycin-Not-a-Rapalog \" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Alpha-Ketoglutarate dietary supplementation to improve health in humans                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Alpha-Ketoglutarate dietary supplementation to improve health in humans Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation. These pleiotropic functions of AKG suggest it may also extend human healthspan. Recent studies in ...<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/www.cell.com\/trends\/endocrinology-metabolism\/fulltext\/S1043-2760(21)00266-6\" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Effects of blood flow restriction (BFR) with resistance exercise on musculoskeletal health in older adults: a narrative review                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Aging leads to a number of structural and physiological deficits such as loss of muscle mass and strength. Strength training at ~ 70% of 1 repetition max (RM) is recommended to prevent age-related loss of muscle mass and strength. However, most older adults may not be able to perform 70% of 1RM or higher intensity. [&hellip;]<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/eurapa.biomedcentral.com\/articles\/10.1186\/s11556-022-00294-0\" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Ironing out exercise on immuno-oncological outcomes                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>Despite accumulating evidence that supports the beneficial effects of physical exercise in inhibiting cancer progression, whether exercise modulates its effects through systemic and cellular changes in iron metabolism and immune-tumor crosstalk is unknown. Cancer cells have greater metabolic requirements than normal cells, with their survival and proliferation depending largely on iron bioavailabi...<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/jitc.bmj.com\/content\/10\/9\/e002976 \" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                            <div class=\"cards-middle\">\n                    <div class=\"column-left\">\n                        <p class=\"pub-title\">\n                            Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?                        <\/p>\n                        <div style=\"max-height: 60px; overflow: hidden;\">\n                            <p style=\"font-family: Poppins; color: #050505;\">\n                                <p>The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and vascular disease in severe patients. The damaged endothelial system provides a good explanation for the various complications seen in COVID-19 patients. These observations [&...<\/p>\n                            <\/p>\n                        <\/div>\n                    <\/div>\n                    <div class=\"column-right\">\n                        <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1568163720303366 \" target=\"_blank\">\n                            <div class=\"read_more\">\n                                Read More <img decoding=\"async\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/healthy-longevity\/wp-content\/themes\/nus-healthy-longevity\/images\/right-arrows-o.svg\" height=\"12px;\" width=\"auto\">\n                            <\/div>\n                        <\/a>\n                    <\/div>\n                    <br style=\"clear:both;\" \/>\n                <\/div>\n                        <\/div>\n<\/div>\n<style>\n    .navigation{\n      margin-top: 20px;\n  }\n  .navigation li a,\n.navigation li a:hover,\n.navigation li.active a,\n.navigation li.disabled {\n    color: #000;\n    text-decoration:none;\n}\n\n.navigation li {\n    display: inline;\n}\n\n.navigation li a,\n.navigation li a:hover,\n.navigation li.active a,\n.navigation li.disabled {\n    background-color: transparent;\n    border-radius: 10px;\n    cursor: pointer;\n    padding: 10px 20px;\n    font-weight: 600;\n}\n\n.navigation li a:hover,\n.navigation li.active a {\n    background-color: var( --e-global-color-primary );\n    color: #fff;\n}\n<\/style>\n    <script>\n    function SubmitForm(formId) {\n        var oForm = document.getElementById(formId);\n        if (oForm) {\n            oForm.submit();\n        } else {\n            console.log(\"DEBUG - 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