{"id":1718,"date":"2023-07-16T19:20:03","date_gmt":"2023-07-16T11:20:03","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/?page_id=1718"},"modified":"2023-11-06T19:42:39","modified_gmt":"2023-11-06T11:42:39","slug":"m2carddage","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/flagship-projects\/m2carddage\/","title":{"rendered":"M2CardAGE"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1718\" class=\"elementor elementor-1718\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b2d4a56 e-flex e-con-boxed e-con e-parent\" data-id=\"b2d4a56\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b66a6ac e-con-full e-flex e-con e-child\" data-id=\"b66a6ac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f45427 elementor-widget elementor-widget-heading\" data-id=\"3f45427\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">M2CardAGE<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cafe308 elementor-widget elementor-widget-heading\" data-id=\"cafe308\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Molecular and Biomechanical Underpinnings of Cardiac Ageing<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b8c5ad elementor-absolute elementor-widget__width-auto elementor-widget elementor-widget-heading\" data-id=\"9b8c5ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Researchers from the M2CardAGE Programme<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7099b1c e-flex e-con-boxed e-con e-parent\" data-id=\"7099b1c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f7dd508 e-con-full e-flex e-con e-child\" data-id=\"f7dd508\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-543ecfa elementor-mobile-align-left elementor-widget elementor-widget-breadcrumbs\" data-id=\"543ecfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p id=\"breadcrumbs\"><span><span><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/\">Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0ae01c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b0ae01c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd2fb53\" data-id=\"fd2fb53\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b8b38d elementor-widget elementor-widget-heading\" data-id=\"7b8b38d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Team<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb2d215 elementor-widget elementor-widget-text-editor\" data-id=\"eb2d215\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"\/trp\/cardiovascular-disease\/about-us\/our-people\/#matthew-ackers-johnson\">Matthew Ackers-Johnson<\/a>, <a href=\"\/trp\/cardiovascular-disease\/about-us\/our-people\/#roger-foo\">Roger Foo<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18afe6f elementor-widget elementor-widget-spacer\" data-id=\"18afe6f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1bf865 elementor-widget elementor-widget-heading\" data-id=\"c1bf865\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Collaborating Institutions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d09480b elementor-widget elementor-widget-text-editor\" data-id=\"d09480b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mechanobiology Institute (NUS)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63955cb elementor-widget elementor-widget-spacer\" data-id=\"63955cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f7473c elementor-widget elementor-widget-heading\" data-id=\"6f7473c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Project<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8118c5 elementor-widget elementor-widget-text-editor\" data-id=\"a8118c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The overarching goal of this project is to gain a mechanistic understanding of how the molecular and mechanical functions of heart cells and tissue change during ageing. Knowledge gained aims to springboard innovative diagnostic methods and treatments for age-related cardiovascular disease (CVD) of direct applicability to the Singaporean population. Singapore is among the top nations with rapidly ageing populations. CVD is a significant barrier to healthy ageing, accounting for ~30% of chronic conditions in the old, and contributing substantially to the healthcare burden of chronic diseases in the Singaporean elderly. The heart is therefore a key focus if Singapore is to achieve healthy longevity. Here, we propose to tackle an overarching hallmark of ageing hearts: cardiac stiffness. As the heart ages, it undergoes major structural biomechanical changes inside the cell and in the tissue around cells. We hypothesize that long-term stress leads to significant molecular and mechanobiological changes, which in turn results in cardiac stiffness, contributing to ageing diseases such as heart failure.<\/p><p>Our project is built on 3 converging and interactive themes, based on increasing scales, from molecules to cells and tissue, culminating in an integrated framework explaining age-associated cardiac stiffness:<\/p><p>(1) Molecular characterization of cardiac ageing<br \/>(2) Intracellular mechanics in cardiomyocyte ageing, and <br \/>(3) Extracellular interactions and architecture in ageing hearts.<\/p><p>This ambitious and highly interdisciplinary research brings together basic biomedical and clinical research units at the NUS Faculty of Science, Faculty of Engineering, and YLL School of Medicine, and the CVMD programme at Duke-NUS. Collectively, our fully integrated effort will lead to a new paradigm of cardiac ageing research in Singapore, with a unique conceptual framework for age-associated cardiac diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-333afd2 elementor-widget elementor-widget-spacer\" data-id=\"333afd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c96e905 elementor-widget elementor-widget-image\" data-id=\"c96e905\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1346\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure.png\" class=\"attachment-full size-full wp-image-3051\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure.png 1920w, https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure-300x210.png 300w, https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure-1024x718.png 1024w, https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure-768x538.png 768w, https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/09\/Atlas-of-the-aging-heart-Extracted-Figure-1536x1077.png 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>M2CardAGE Molecular and Biomechanical Underpinnings of Cardiac Ageing Researchers from the M2CardAGE Programme Team Matthew Ackers-Johnson, Roger Foo Collaborating Institutions Mechanobiology Institute (NUS) Project The overarching goal of this project is to gain a mechanistic understanding of how the molecular and mechanical functions of heart cells and tissue change during ageing. Knowledge gained aims to [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":424,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1718","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>M2CardAGE - Cardiovascular-Metabolic Disease<\/title>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"M2CardAGE - Cardiovascular-Metabolic Disease\" \/>\n<meta property=\"og:description\" content=\"M2CardAGE Molecular and Biomechanical Underpinnings of Cardiac Ageing Researchers from the M2CardAGE Programme Team Matthew Ackers-Johnson, Roger Foo Collaborating Institutions Mechanobiology Institute (NUS) Project The overarching goal of this project is to gain a mechanistic understanding of how the molecular and mechanical functions of heart cells and tissue change during ageing. 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