{"id":1121,"date":"2023-07-13T15:22:55","date_gmt":"2023-07-13T07:22:55","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/?page_id=1121"},"modified":"2023-11-06T18:33:39","modified_gmt":"2023-11-06T10:33:39","slug":"basic-translational-research","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/basic-translational-research\/","title":{"rendered":"Basic &#038; Translational Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1121\" class=\"elementor elementor-1121\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-47e7c29 e-flex e-con-boxed e-con e-parent\" data-id=\"47e7c29\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-99aa33d e-con-full e-flex e-con e-child\" data-id=\"99aa33d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-60479d7 elementor-widget elementor-widget-heading\" data-id=\"60479d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Research Themes<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-77ac691 elementor-absolute elementor-widget__width-auto elementor-widget-mobile__width-auto elementor-widget elementor-widget-heading\" data-id=\"77ac691\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">A heart pump model<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d8569a e-flex e-con-boxed e-con e-parent\" data-id=\"5d8569a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c1a952a e-con-full e-flex e-con e-child\" data-id=\"c1a952a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2b55096 elementor-mobile-align-left elementor-widget elementor-widget-breadcrumbs\" data-id=\"2b55096\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p id=\"breadcrumbs\"><span><span><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/\">Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fe0b510 e-flex e-con-boxed e-con e-parent\" data-id=\"fe0b510\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f42655f e-con-full e-flex e-con e-child\" data-id=\"f42655f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b0c72f7 elementor-widget elementor-widget-image\" data-id=\"b0c72f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/basic-translational-research\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"67\" height=\"68\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/07\/icon-dna.svg\" class=\"attachment-full size-full wp-image-163\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-61f2484 elementor-widget elementor-widget-heading\" data-id=\"61f2484\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/basic-translational-research\/\">Basic &amp; Translational Research<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-359517c e-con-full e-flex e-con e-child\" data-id=\"359517c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3170b0c elementor-widget elementor-widget-image\" data-id=\"3170b0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/clinical-trials-clinical-research\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"72\" height=\"54\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/07\/icon-heart.svg\" class=\"attachment-full size-full wp-image-165\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b7d711 elementor-widget elementor-widget-heading\" data-id=\"8b7d711\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/clinical-trials-clinical-research\/\">Clinical Trials &amp; Clinical Research <\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-783a9f8 e-con-full e-flex e-con e-child\" data-id=\"783a9f8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c0c79a6 elementor-widget elementor-widget-image\" data-id=\"c0c79a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/medical-technology-devices\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"61\" height=\"72\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/07\/icon-medical.svg\" class=\"attachment-full size-full wp-image-166\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c6c8fa elementor-widget elementor-widget-heading\" data-id=\"6c6c8fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/medical-technology-devices\/\">Medical Technology &amp; Devices<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-27fa691 e-con-full e-flex e-con e-child\" data-id=\"27fa691\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8edded8 elementor-widget elementor-widget-image\" data-id=\"8edded8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/data-science-bioinformatics\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"69\" height=\"68\" src=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/wp-content\/uploads\/sites\/14\/2023\/07\/icon-data.svg\" class=\"attachment-full size-full wp-image-164\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da0e62e elementor-widget elementor-widget-heading\" data-id=\"da0e62e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/research-themes\/data-science-bioinformatics\/\">Data Science &amp; Bioinformatics<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aa0bb51 e-flex e-con-boxed e-con e-parent\" data-id=\"aa0bb51\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b8fc353 e-con-full e-flex e-con e-child\" data-id=\"b8fc353\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-606ae6e elementor-widget elementor-widget-heading\" data-id=\"606ae6e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">GOALS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-240623f elementor-widget elementor-widget-text-editor\" data-id=\"240623f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The goal of our Basic and Translational Research theme is to discover new markers of disease, <span lang=\"en-IO\">and <\/span>elucidate mechanisms and pathways that can be targeted for novel therapies. These are built upon a suite of capabilities including genomics, stem cells, RNA biology, models of disease, CRISPR gene editing through to genome-wide screens.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-22a5559 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"22a5559\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-85b9f7b\" data-id=\"85b9f7b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e1acd09 elementor-widget elementor-widget-html\" data-id=\"e1acd09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n<script>\n\ndocument.addEventListener('DOMContentLoaded',function(){\n\nlet scrollableNavigations = document.querySelectorAll('.e-n-tabs-heading');\n\nscrollableNavigations.forEach((scrollableNavigation, index) => {\nlet navigationItems = scrollableNavigation.querySelectorAll('.e-n-tab-title');\n\nscrollableNavigation.style.scrollBehavior = \"smooth\";\n\nnavigationItems.forEach((navigationItem,i) => {\nlet scrollToPosition = (navigationItem.getBoundingClientRect().left + navigationItem.offsetWidth\/2) - (window.innerWidth\/2);\nnavigationItem.addEventListener('click',function(event){\nscrollableNavigation.scrollTo(scrollToPosition, 0);\n});\n});\n});\n\n});\n<\/script>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de35c4f elementor-widget elementor-widget-heading\" data-id=\"de35c4f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Sub-Themes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f70d574 e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"f70d574\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;tabs_justify_horizontal&quot;:&quot;stretch&quot;,&quot;horizontal_scroll&quot;:&quot;disable&quot;}\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"259052916\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"cb\" data-tab-title-id=\"e-n-tab-title-2590529161\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-2590529161\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t<div class=\"number\">01<\/div> Cardiovascular Biomarkers\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"cge\" data-tab-title-id=\"e-n-tab-title-2590529162\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-2590529162\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t<div class=\"number\">02<\/div> Cardiovascular Genetics &amp; Epigenetics\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"vb\" data-tab-title-id=\"e-n-tab-title-2590529163\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-2590529163\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t<div class=\"number\">03<\/div> Vascular Biology\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-2590529161\" role=\"tabpanel\" aria-labelledby=\"cb\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-b0b63c4 e-con-full e-flex e-con e-child\" data-id=\"b0b63c4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-df43a0f elementor-widget elementor-widget-text-editor\" data-id=\"df43a0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>As physicians, we are interested in biomarkers because we use them often to make diagnoses of diseases, and they often also help us to track disease progression. In the setting of cardiovascular disease, our TRP research teams study biomarkers in the form of proteins, nucleic acids and metabolites, using technologies and capabilities including mass spectrometry and data informatics for the discovery of new actionable biomarkers to guide clinical care. Our approach encompasses clinical trial design and execution, in addition to novel assay design. A specific interest is the use of quantified drug and drug metabolite levels, sourced from standard clinical workflows, for the guidance of prescription management.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af9ca24 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"af9ca24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"\/trp\/cardiovascular-disease\/about-us\/our-people\/basic-translational-research\/?cardiovascular-biomarkers\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24.25\" height=\"12.578\" viewBox=\"0 0 24.25 12.578\"><g id=\"Icon_feather-arrow-right\" data-name=\"Icon feather-arrow-right\" transform=\"translate(6 -6.086)\"><path id=\"Path_47997\" data-name=\"Path 47997\" d=\"M7.5,18H29.75\" transform=\"translate(-12.5 -5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><path id=\"Path_47998\" data-name=\"Path 47998\" d=\"M18,7.5l4.875,4.875L18,17.25\" transform=\"translate(-5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">view theme members<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-2590529162\" role=\"tabpanel\" aria-labelledby=\"cge\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-0372f68 e-con-full e-flex e-con e-child\" data-id=\"0372f68\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3414a03 elementor-widget elementor-widget-text-editor\" data-id=\"3414a03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>For the study of human diseases, genetics comes closest to uncovering causality. Our TRP research teams make use of next-generation sequencing and Long Read Sequencing technologies as a routine to study genomics, genetics and the molecular epigenetic control of gene programmes. As a routine, our studies of disease mechanisms make use of animal models as well as patient-based induced pluripotent stem cell platforms, and CRISPR gene editing techniques.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-28c2d32 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"28c2d32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"\/trp\/cardiovascular-disease\/about-us\/our-people\/basic-translational-research\/?cge\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24.25\" height=\"12.578\" viewBox=\"0 0 24.25 12.578\"><g id=\"Icon_feather-arrow-right\" data-name=\"Icon feather-arrow-right\" transform=\"translate(6 -6.086)\"><path id=\"Path_47997\" data-name=\"Path 47997\" d=\"M7.5,18H29.75\" transform=\"translate(-12.5 -5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><path id=\"Path_47998\" data-name=\"Path 47998\" d=\"M18,7.5l4.875,4.875L18,17.25\" transform=\"translate(-5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">view theme members<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-2590529163\" role=\"tabpanel\" aria-labelledby=\"vb\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-4f965bf e-con-full e-flex e-con e-child\" data-id=\"4f965bf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b235c67 elementor-widget elementor-widget-text-editor\" data-id=\"b235c67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Vascular research in our TRP covers coronary artery disease, lipid and bile acid biology, as well as peripheral artery disease. We make use of animal models and host a large biobank of human tissue.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5bfd48 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"f5bfd48\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"\/trp\/cardiovascular-disease\/about-us\/our-people\/basic-translational-research\/?vascular-viology\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24.25\" height=\"12.578\" viewBox=\"0 0 24.25 12.578\"><g id=\"Icon_feather-arrow-right\" data-name=\"Icon feather-arrow-right\" transform=\"translate(6 -6.086)\"><path id=\"Path_47997\" data-name=\"Path 47997\" d=\"M7.5,18H29.75\" transform=\"translate(-12.5 -5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><path id=\"Path_47998\" data-name=\"Path 47998\" d=\"M18,7.5l4.875,4.875L18,17.25\" transform=\"translate(-5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">view theme members<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-c6d8463 e-flex e-con-boxed e-con e-parent\" data-id=\"c6d8463\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-54a2508 e-con-full e-flex e-con e-child\" data-id=\"54a2508\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3aca335 elementor-widget elementor-widget-heading\" data-id=\"3aca335\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Catch up on the latest updates at<br>\nResearch Highlights<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aa35c98 e-con-full e-flex e-con e-child\" data-id=\"aa35c98\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0f74993 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"0f74993\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/medicine.nus.edu.sg\/trp\/cardiovascular-disease\/news-events\/research-highlights\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"24.25\" height=\"12.578\" viewBox=\"0 0 24.25 12.578\"><g id=\"Icon_feather-arrow-right\" data-name=\"Icon feather-arrow-right\" transform=\"translate(6 -6.086)\"><path id=\"Path_47997\" data-name=\"Path 47997\" d=\"M7.5,18H29.75\" transform=\"translate(-12.5 -5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><path id=\"Path_47998\" data-name=\"Path 47998\" d=\"M18,7.5l4.875,4.875L18,17.25\" transform=\"translate(-5.625)\" fill=\"none\" stroke=\"#fff\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Research Highlights<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Themes A heart pump model Basic &#038; Translational Research Clinical Trials &#038; Clinical Research Medical Technology &#038; Devices Data Science &#038; Bioinformatics GOALS The goal of our Basic and Translational Research theme is to discover new markers of disease, and elucidate mechanisms and pathways that can be targeted for novel therapies. These are built [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"parent":422,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1121","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Basic &amp; Translational Research - Cardiovascular-Metabolic Disease<\/title>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Basic &amp; Translational Research - Cardiovascular-Metabolic Disease\" \/>\n<meta property=\"og:description\" content=\"Research Themes A heart pump model Basic &#038; Translational Research Clinical Trials &#038; Clinical Research Medical Technology &#038; Devices Data Science &#038; Bioinformatics GOALS The goal of our Basic and Translational Research theme is to discover new markers of disease, and elucidate mechanisms and pathways that can be targeted for novel therapies. 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