{"id":72113,"date":"2023-06-26T08:48:30","date_gmt":"2023-06-26T00:48:30","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/taps\/?post_type=issues&#038;p=72113"},"modified":"2023-10-03T08:09:29","modified_gmt":"2023-10-03T00:09:29","slug":"a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge","status":"publish","type":"issues","link":"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/","title":{"rendered":"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge"},"content":{"rendered":"<p>Submitted: 16 May 2022<br \/>\r\nAccepted: 3 January 2023<br \/>\r\nPublished online: 4 July, TAPS 2023, 8(3), 5-14<br \/>\r\n<a href=\"https:\/\/doi.org\/10.29060\/TAPS.2023-8-3\/OA2813\">https:\/\/doi.org\/10.29060\/TAPS.2023-8-3\/OA2813<\/a><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Bikramjit Pal<sup>1<\/sup>, Aung Win Thein<sup>2<\/sup>, Sook Vui Chong<sup>3<\/sup>, Ava Gwak Mui Tay<sup>4<\/sup>, Htoo Htoo Kyaw Soe<sup>5<\/sup> &amp; Sudipta Pal<sup>6<\/sup><\/span><span lang=\"EN-GB\"><\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><sup><span lang=\"EN-MY\">1<\/span><\/sup><\/i><i><span lang=\"EN-MY\">Department of Surgery, Manipal University College Malaysia, Melaka, Malaysia; <sup>2<\/sup>Department of Surgery, Manipal University College Malaysia, Melaka, Malaysia; <sup>3<\/sup>Department of Medicine, Manipal University College Malaysia, Melaka, Malaysia; <sup>4<\/sup>Department of Surgery, Manipal University College Malaysia, Melaka, Malaysia; <sup>5<\/sup>Department of Community Medicine, Manipal University College Malaysia, Melaka, Malaysia; <sup>6<\/sup>Department of Community Medicine, Manipal University College Malaysia, Melaka, Malaysia<\/span><\/i><\/p>\r\n<p style=\"text-align: center;\"><b><span lang=\"EN-GB\">Abstract <\/span><\/b><\/p>\r\n<p style=\"text-align: justify;\"><b><span lang=\"EN-GB\">Introduction:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-US\">The practice of high-fidelity simulation-based medical education has become a popular small-group teaching modality across all spheres of clinical medicine. High-fidelity simulation (HFS) is now being increasingly used in the context of undergraduate medical education, but its superiority over traditional teaching methods is still not established. The main objective of this study was to analyse the effectiveness of HFS-based teaching over video-assisted lecture (VAL)-based teaching in the enhancement of knowledge for the management of tension pneumothorax among undergraduate medical students.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><b><span lang=\"EN-GB\">Methods:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-US\">A cohort of 111 final-year undergraduate medical students were randomised for this study. The efficacy of HFS-based teaching (intervention group) and VAL-based teaching (control group), on the acquisition of knowledge, was assessed by single-best answer multiple choice questions (MCQ) tests in the first and eighth week of their surgery posting. Mean and standard deviation (SD) for the total score of MCQ assessments were used as outcome measures. ANCOVA was used to determine the difference in post-test MCQ marks between groups. The intragroup comparison of the pre-test and post-test MCQ scores was done by using paired t-test. The P-value was set at 0.05.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><b><span lang=\"EN-GB\">Results:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-US\">The mean of post-test MCQ scores were significantly higher than the mean of pre-test MCQ scores in both groups. The mean pre-test and post-test MCQ scores in the intervention group were slightly more than those of the control group but not statistically significant.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><b><span lang=\"EN-GB\">Conclusion:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-US\">There was a statistically significant enhancement of knowledge in both groups but the difference in knowledge enhancement between the groups was insignificant.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><b><span lang=\"EN-GB\">Keywords<\/span><\/b><b><span lang=\"EN-GB\">:<\/span><\/b><span lang=\"EN-GB\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><i><span lang=\"EN-MY\">High-Fidelity Simulation, Video-Assisted Lecture, Simulation-Based Medical Education (SBME), Randomized Controlled Trial (RCT), Medical Education, Pre-test and Post-test Knowledge Assessments<\/span><\/i><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Practice Highlights <\/span><\/strong><\/p>\r\n<ul>\r\n\t<li style=\"text-align: justify;\"><span lang=\"EN-MY\"> <\/span><span lang=\"EN-MY\">An RCT study to evaluate the effectiveness of HFS over video-assisted lecture teaching method.<\/span><\/li>\r\n\t<li style=\"text-align: justify;\"><span lang=\"EN-MY\"> <\/span><span lang=\"EN-MY\">HFS seems to be not superior than VAL-based teaching for knowledge acquisition and retention.<\/span><\/li>\r\n\t<li style=\"text-align: justify;\"><span lang=\"EN-MY\"> <\/span><span lang=\"EN-MY\">HFS may be used judiciously when the objectives are mainly knowledge based.<\/span><\/li>\r\n\t<li style=\"text-align: justify;\"><span lang=\"EN-GB\"> <\/span><span lang=\"EN-US\">Further research may determine curricular areas where HFS is superior and worth adopting<\/span><span lang=\"EN-MY\">.<\/span><\/li>\r\n<\/ul>\r\n<p style=\"text-align: center;\"><strong><span lang=\"EN-MY\">I. <\/span><span lang=\"EN-GB\"><\/span><span lang=\"EN-GB\"><\/span><span lang=\"EN-GB\">INTRODUCTION<\/span><\/strong><\/p>\r\n<ol><\/ol>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-GB\">High-Fidelity Simulation (HFS) is an innovative healthcare education methodology that involves the use of sophisticated life-like mannequins to create a realistic patient environment. HFS can be considered an innovative teaching method that aids students in translating knowledge and psychomotor skills from the classroom to the actual clinical setting. Kolb\u2019s Experiential Learning Cycle (Kolb, 1984) provides a basis for the integration of active learning of simulation with conventional teaching methods for a comprehensive learning experience in undergraduate medical education. HFS-based education is potentially an efficacious pedagogy that is now available for teaching. The usefulness of HFS has been recognized by the Accreditation Council of Graduate Medical Education (Accreditation Council of Graduate Medical Education [ACGME], 2020). HFS has the added benefit of increasing students\u2019 confidence and their ability to care for the patients at the bedside<\/span><span lang=\"EN-MY\"> (Kiernan, 2018). HFS-based education and video-assisted lecture-based teaching are both effective in achieving factual learning. Despite the increasing acceptance of HFS, there are limited studies to compare the usefulness of HFS with conventional teaching methods for factual learning among undergraduate medical students. At present, the different research studies have not provided enough evidence to establish HFS-based teaching\u2019s superiority over traditional educational methods in the acquisition and retention of knowledge. There is inconsistent and variable outcome regarding the effectiveness of HFS on student learning (Yang &amp; Liu, 2016). HFS-based education is both time-consuming and resource intensive. Its long-term merits in retaining knowledge and translating it into enhanced patient care need further research. As educators, we need to systematically evaluate the expensive newer teaching-learning modules like HFPS for their effectiveness by using rigorous research methodology and protocols. This is to ensure that we are providing the best learning opportunities conceivable for the students. Previous studies were mostly done in North America and, therefore, the generalisability of these results is guarded and might not be applicable in the context of Europe and Asia due to many differences in academic and curriculum aspects (Davies, 2008). The purpose of this study was to establish the feasibility of the use of HFS to deliver critical care education to final-year medical students and to find its efficacy in the enhancement of knowledge when compared to video-assisted lectures. The study compared the effectiveness of two methods of teaching pedagogy in the enhancement of knowledge acquisition using pre-test and post-test MCQ. This study was designed to provide insights that may be applied to the future development and improvement of HFS-based education among undergraduate medical students and its possibility of integrating it into course curricula.<\/span><\/p>\r\n<p style=\"text-align: center;\"><span lang=\"EN-GB\"><\/span><strong><span lang=\"EN-GB\">II. METHODS<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-GB\">A. Study Design<\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Randomized Controlled Trial (RCT) with parallel groups and 1:1 allocation. Please see Appendix 1 for the Flow Chart.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-GB\">B. Sample Size<\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">G*Power software was used to calculate the sample size (Faul et al., 2007). Based on the preliminary RCT study of our institute done with the same protocol in 2018, the calculated sample size was 114 with a power of 0.95 for this study.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-US\"><\/span><\/i><i><span lang=\"EN-US\">C. Inclusion and Exclusion Criteria<\/span><\/i><i><span lang=\"EN-US\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">All male and female final-year undergraduate medical (MBBS) students in our institute were recruited after obtaining their written informed consent. All final-year students in the institute consented to the study. The participants were between the ages of 22-26 years. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The total number of participants recruited was 123.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The number of participants dropped out was 12 (9.77%).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Out of 111 participants who completed the study, 61 (54.95%) were female and 50 (45.05%) were male.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The study was conducted in the Clinical Skills Simulation Lab of Melaka Manipal Medical College (presently known as Manipal University College Malaysia). <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The study period was from March 2019 to February 2020 (12 months).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">D. Interventions<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-MY\"><\/span><\/i><i><span lang=\"EN-MY\">1) Description of HFPS-based teaching<\/span><\/i><span lang=\"EN-MY\">: It was an interactive session using a high-fidelity patient simulator demonstrating the management of tension pneumothorax by performing Needle Decompression on METIman (Pre-Hospital) following the Advanced Trauma Life Support Manual developed by the American College of Surgeons (ATLS Subcommittee et al., 2013).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-MY\"><\/span><\/i><i><span lang=\"EN-MY\">2) Description of Hi-fidelity simulator<\/span><\/i><span lang=\"EN-MY\">: METIman Pre-Hospital HI-Fidelity Simulator (MMP-0418) was used for the simulation sessions. It was a fully wireless, adult High-Fidelity Patient Simulator (HFPS) with modelled physiology. It comes with extensive clinical features and capabilities designed specifically for learners to practice, gain experience, and develop clinical mastery in a wide range of patient care scenarios.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-MY\"><\/span><\/i><i><span lang=\"EN-MY\">3) Description of video-assisted lecture-based teaching<\/span><\/i><span lang=\"EN-MY\">: It was a small group interactive session delivered face-to-face to the participants using a recorded video clip demonstrating the management of tension pneumothorax by performing Needle Decompression on METIman (Pre-Hospital) following the Advanced Trauma Life Support Manual developed by the American College of Surgeons (ATLS Subcommittee et al., 2013). <\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">E. Outcome<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The tool for measurement of knowledge was an identical set of single-best answer A-type MCQs. These MCQs were used for both Pre-test and Post-test knowledge assessments. MCQs were constructed based on the teaching sessions to assess their learning outcome.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">T<\/span><span lang=\"EN-US\">he efficacy of HFPS-based teaching when compared to video-assisted lecture-based teaching is enhancement of knowledge for management of tension pneumothorax. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">F. Recruitment<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The students were recruited in the study during their final year surgical posting. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">G. Randomisation<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">A cohort of 12 to 14 students from each rotation was randomised into intervention (HFPS-based teaching) and control (video-assisted lecture-based teaching) groups following random sequence generation method. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">A computer-generated random sequence number was developed from randomizer.org. The independent randomiser was a biostatistician who did not participate in the delivery of interventions. The allocated interventions were then sealed in a sequentially numbered, opaque envelope. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Block randomisation with a block size of two was used to assign the students into intervention and control groups. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">H. Implementation<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">A biostatistician generated the allocation sequence. One independent investigator enrolled the participants, and another independent investigator assigned the participants to interventions. The outcome assessor and the biostatistician were kept blinded to the randomisation.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">I. Procedure for Data Collection<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The participants who gave consent were enrolled in the study. Each session was conducted with a group of 12 to 14 participants. On the first day, the participants were briefed about the sessions and expected learning outcomes. As part of the briefing process, they were explained the confidentiality of the HFPS, the video-assisted lecture sessions and the ethical issues involved. All the participants were introduced to the high-fidelity patient simulator (METIman) in the clinical lab set-up to make them aware of its functions and familiarise them with the handling of the mannequin. An assurance was given to the students that the training course was not part of the evaluation process for the surgical curriculum. The briefing was followed by the first knowledge assessment (Pre-test MCQ) of all the participants. Pre-test MCQ was designed to collect the score of initial background knowledge about tension pneumothorax and its management following the ATLS protocol. The module for the aetiology, pathophysiology and clinical presentation of tension pneumothorax and its steps of management following the ATLS protocol was part of their final year course curriculum. It was taught before they participated in the study. After the Pre-test MCQ session, they were randomized into intervention and control groups consisting of 6 to 7 participants each. For the intervention group, an independent investigator used the high-fidelity simulator (METIman Pre-hospital) to demonstrate the diagnosis and management of tension pneumothorax (Needle Decompression) in an emergency setting. The demonstration time was 20 minutes followed by hands-on training for another 20 minutes. For the control group, a recorded video clip of the identical facilitated simulation session on the diagnosis and management of tension pneumothorax (Needle Decompression) was shown by another investigator. The video demonstration lasted for 20 minutes. This session was followed by a 20-minute interactive discussion session with the faculty. All the participants in both groups were apprised of the importance of aetiology, pathophysiology and clinical presentation in arriving at the diagnosis and management of tension pneumothorax during these interactive teaching sessions. The participants were encouraged to explore how they would manage the stated clinical situation through discussion. The faculty were instructed to emphasize the teaching points related to the outcome of the study. The total duration for both types of teaching was 40 minutes. There were no more additional hands-on practice or video-assisted lecture sessions for the participants during the course of the research study. In the seventh\/eighth week, both the intervention and the control groups again participated in the second knowledge assessment (Delayed Post-test MCQ) to assess their gain and retention of knowledge. Delayed Post-test MCQ assessment may minimise the recall bias and test their retained memory better.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Both Pre-test and Post-test knowledge assessments comprised 20 MCQs which were to be completed in 20 minutes. The single-best answer A-type MCQs with five options of answers were prepared following the guidelines framed by the National Board of Medical Examiners (Case &amp; Swanson, 2001). For each correct response, a score of one point was awarded. No negative marking was awarded for incorrect response. Based on the learning objectives, the MCQs were constructed by 6 experts in the field of Surgery, Medicine and Medical Education who were not part of this research study. The MCQs covered the items on pathophysiology, diagnosis, and management of tension pneumothorax, and assessed for knowledge comprehension and knowledge application. The order of the questions was changed between the Pre-test and the Post-test. The MCQ answer sheets were scanned by Konica Minolta FM (172.17.5.12) scanner and graded by using Optical Mark Recognition (OMR) software (Remark Office OMR, version 9.5, 2014; Gravic Inc., USA). Before the main study, a preliminary study involving 56 students was conducted to explore the time management, feasibility, acceptability, and validation of the MCQs (Pal et al., 2021). In the preliminary study, the Pre-test and the Post-test were administered in the first week and the fourth week respectively to note the short-term retention of knowledge. This study is an extension of the preliminary study with a different cohort of students where the Pre-test and the Delayed Post-test were administered in the first week and the seventh\/eighth week respectively to determine the medium-term retention of knowledge. The MCQs were reviewed based on the feedback from the preliminary study on the appropriateness of the content, clarity in wording, and difficulty level. The difficulty index and the bi-serial correlation for item discrimination of all MCQs were checked. The value between 30 and 95 in the difficulty index and the bi-serial correlation value &gt; 0.2 were chosen as the accepted standard for this study.\u00a0 <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">At the end of the study, the participants in the intervention group were provided with access to the identical video-assisted lecture sessions as designed for the control group. Similarly, the participants in the control group were provided with access to the same HFS sessions. This is to ensure parity between the groups for their professional development of knowledge.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-US\">J. Statistical Analysis<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">SPSS software (version 25) was used for data analysis. The descriptive statistics such as frequency and percentage for categorical data and the mean and standard deviation for the total score of the assessments were calculated. ANCOVA was used to determine the difference in post-test MCQ marks between intervention and control groups with pre-test MCQ marks as a covariate. Intragroup comparison of pre-test and post-test MCQ marks was also done by calculating paired t-test. For intergroup comparison, the effect size &#8211; Partial Eta Squared was calculated in ANCOVA. Cohen\u2019s dz was calculated for the comparison of dependent means. The level of significance was set at 0.05 and the null hypothesis was rejected when P &lt; 0.05. We measured the scale-level content validity index (SCVI) and item-level content validity index (ICVI) for the validity and Cronbach alpha for the internal consistency (reliability) of the MCQs. The average values of SCVI and ICVI were 0.94 &amp; 0.89 respectively. The value of Cronbach&#8217;s alpha was 0.78.<\/span><\/p>\r\n<p style=\"text-align: center;\"><span lang=\"EN-GB\"><\/span><strong><span lang=\"EN-GB\">III. RESULTS<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The data that support the findings this RCT study are openly available at <a href=\"https:\/\/doi.org\/10.6084\/m9.figshare.19932053\">https:\/\/doi.org\/10.6084\/m9.figshare.19932053<\/a> (Pal et al., 2022).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-MY\">A. General Data Analysis<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">There was no difference in the highest Pre-test scores achieved by the participants in both intervention and control groups. The lowest scores recorded in the intervention group were better than the control group in both Pre-test and Post-test. There was a negligible difference between the highest Post-test scores among control and intervention groups (See Table 1).<\/span><\/p>\r\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" align=\"left\" width=\"100%\" style=\"width: 100%;\">\r\n<tbody>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><b><span lang=\"EN-MY\">Test score<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><b><span lang=\"EN-MY\">Intervention<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><b><span lang=\"EN-MY\">Control<\/span><\/b><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"100%\" colspan=\"3\">\r\n<p align=\"center\"><span lang=\"EN-MY\">PRE-TEST<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">\u00a0Mean (SE)<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">12.31 (0.34)<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">12.23 (0.36)<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">\u00a095% CI for Mean<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">11.64 \u2013 12.98<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">11.50 \u2013 12.96<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">\u00a0Min \u2013 Max<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">6.0 \u2013 18.0<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">6.0 \u2013 18.0<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"100%\" colspan=\"3\">\r\n<p align=\"center\"><span lang=\"EN-MY\">POST-TEST<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">\u00a0Mean (SE)<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">13.65 (0.27)<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">13.60 (0.30)<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">\u00a095% CI for Mean<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">13.12 \u2013 14.19<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">12.98 \u2013 14.20<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"42%\">\r\n<p><span lang=\"EN-MY\">Min \u2013 Max<\/span><\/p>\r\n<\/td>\r\n<td width=\"31%\">\r\n<p><span lang=\"EN-MY\">8.0 \u2013 18.0<\/span><\/p>\r\n<\/td>\r\n<td width=\"25%\">\r\n<p><span lang=\"EN-MY\">7.0 \u2013 17.0<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"100%\" colspan=\"3\">\r\n<p align=\"center\"><span lang=\"EN-MY\">Table 1. Highest, lowest and unadjusted mean MCQ scores among intervention and control groups<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"100%\" colspan=\"3\">\r\n<p><span lang=\"EN-MY\">SE \u2013 Standard Error\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 CI \u2013 Confidence Interval<\/span><\/p>\r\n<p><span lang=\"EN-MY\">Min \u2013 Minimum\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Max \u2013 Maximum<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<p style=\"text-align: center;\"><span lang=\"EN-GB\"><\/span><\/p>\r\n<p style=\"text-align: center;\"><\/p>\r\n<div>\r\n<p><i><span lang=\"EN-GB\">B. <\/span><\/i><i><span lang=\"EN-MY\">Statistical Data Analysis<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">ANCOVA was used to determine the difference in Post-test MCQ scores among control and intervention groups after adjusting pre-test MCQ scores. There was a linear relationship between Pre-test and Post-test MCQ scores for each group, as determined by visual inspection of the scatterplot. The homogeneity of regression slopes was noted as the interaction term was not statistically significant, F (1, 107) = 0.889, P = 0.348. When assessed by Shapiro-Wilk&#8217;s test, standardized residuals were normally distributed (P &gt; 0.05) in the intervention group, but not normally distributed in the control group (P &lt; 0.05). Both homoscedasticity and homogeneity of variance were noted, as assessed by visual inspection of a scatterplot and Levene&#8217;s test of homogeneity of variance (P = 0.531), respectively. Data were adjusted with mean \u00b1 standard error unless otherwise stated. The effect size, Partial Eta Squared (Partial \u03b72) was calculated in ANCOVA. A partial \u03b72 value of 0.01 or less was considered to be small. For the comparison of dependent means, the effect size, Cohen\u2019s dz was calculated; where the effect size of 0.5-0.8 was considered to be moderate (Ellis, 2010). Post-test MCQ score was higher in the intervention group but after adjustment for pre-test MCQ scores, there was no statistically significant difference in post-test MCQ scores between the control and intervention groups. The effect size was small (See Table 2).<\/span><\/p>\r\n<\/div>\r\n<div align=\"center\">\r\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"0\" style=\"width: 100%; height: 444px;\">\r\n<tbody>\r\n<tr style=\"height: 95px;\">\r\n<td width=\"98\" valign=\"top\" style=\"height: 95px;\">\r\n<p><strong><span lang=\"EN-MY\">Variable<\/span><\/strong><\/p>\r\n<\/td>\r\n<td width=\"53\" valign=\"top\" style=\"height: 95px;\">\r\n<p><strong><span lang=\"EN-MY\">n<\/span><\/strong><\/p>\r\n<\/td>\r\n<td width=\"180\" valign=\"top\" style=\"height: 95px;\">\r\n<p style=\"text-align: left;\"><strong><span lang=\"EN-MY\">Post-test MCQ score<\/span><\/strong><\/p>\r\n<p style=\"text-align: left;\"><strong><span lang=\"EN-MY\">Mean (SE)<\/span><\/strong><\/p>\r\n<\/td>\r\n<td width=\"142\" valign=\"top\" style=\"height: 95px;\">\r\n<p style=\"text-align: left;\"><strong><span lang=\"EN-MY\">Mean difference (95% CI)<\/span><\/strong><\/p>\r\n<\/td>\r\n<td width=\"76\" valign=\"top\" style=\"height: 95px;\">\r\n<p style=\"text-align: left;\"><strong><span lang=\"EN-MY\">P-value<\/span><\/strong><\/p>\r\n<\/td>\r\n<td width=\"90\" valign=\"top\" style=\"height: 95px;\">\r\n<p><strong><span lang=\"EN-MY\">Partial \u03b7<sup>2<\/sup><\/span><\/strong><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr style=\"height: 55px;\">\r\n<td width=\"98\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">Intervention<\/span><\/p>\r\n<\/td>\r\n<td width=\"53\" valign=\"top\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">55<\/span><\/p>\r\n<\/td>\r\n<td width=\"180\" valign=\"top\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">13.65 (0.27)<\/span><\/p>\r\n<\/td>\r\n<td width=\"142\" rowspan=\"2\" valign=\"top\" style=\"height: 110px;\">\r\n<p><span lang=\"EN-MY\">0.04 (-0.69, 0.77)<\/span><\/p>\r\n<\/td>\r\n<td width=\"76\" rowspan=\"2\" valign=\"top\" style=\"height: 110px;\">\r\n<p><span lang=\"EN-MY\">0.917<\/span><\/p>\r\n<\/td>\r\n<td width=\"90\" rowspan=\"2\" valign=\"top\" style=\"height: 110px;\">\r\n<p><span lang=\"EN-MY\">0.0001<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr style=\"height: 55px;\">\r\n<td width=\"98\" valign=\"top\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">Control<\/span><\/p>\r\n<\/td>\r\n<td width=\"53\" valign=\"top\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">56<\/span><\/p>\r\n<\/td>\r\n<td width=\"180\" valign=\"top\" style=\"height: 55px;\">\r\n<p><span lang=\"EN-MY\">13.60 (0.30)<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr style=\"height: 80px;\">\r\n<td width=\"638\" colspan=\"6\" valign=\"top\" style=\"height: 80px;\">\r\n<p style=\"text-align: center;\"><span lang=\"EN-MY\">Table 2. Intergroup comparison of post-test MCQ scores between intervention and control groups after adjusting pre-test MCQ marks (ANCOVA)<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr style=\"height: 159px;\">\r\n<td width=\"638\" colspan=\"6\" valign=\"top\" style=\"height: 159px;\">\r\n<p><span lang=\"EN-MY\">n: number of students<\/span><\/p>\r\n<p><span lang=\"EN-MY\">SE: Standard error<\/span><\/p>\r\n<p><span lang=\"EN-MY\">95% CI: 95% confidence interval<\/span><\/p>\r\n<p><span lang=\"EN-MY\">Partial \u03b72: Partial Eta Squared<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">There was a statistically significant difference between pre-test and post-test MCQ scores among the intervention and control groups. The mean of post-test MCQ scores was significantly higher than the mean of pre-test MCQ scores in both intervention and control groups. The effect size was moderate in both groups (See Table 3).<\/span><\/p>\r\n<div align=\"center\">\r\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\r\n<tbody>\r\n<tr>\r\n<td width=\"85\" rowspan=\"2\">\r\n<p><b><span lang=\"EN-MY\">Variable<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"57\" rowspan=\"2\">\r\n<p style=\"text-align: center;\"><b><span lang=\"EN-MY\">n<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"161\" colspan=\"2\">\r\n<p style=\"text-align: center;\"><b><span lang=\"EN-MY\">Mean (SD)<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"141\" rowspan=\"2\">\r\n<p style=\"text-align: left;\"><b><span lang=\"EN-MY\">Mean difference (95% CI)<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"66\" rowspan=\"2\">\r\n<p><b><span lang=\"EN-MY\">t (df)<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"77\" rowspan=\"2\">\r\n<p style=\"text-align: center;\"><b><span lang=\"EN-MY\">P-value<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"54\" rowspan=\"2\">\r\n<p style=\"text-align: center;\"><b><span lang=\"EN-MY\">Dz<\/span><\/b><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"85\">\r\n<p><b><span lang=\"EN-MY\">Pre-test MCQ scores<\/span><\/b><\/p>\r\n<\/td>\r\n<td width=\"76\">\r\n<p><b><span lang=\"EN-MY\">Post-test MCQ scores<\/span><\/b><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"85\">\r\n<p><span lang=\"EN-MY\">Intervention<\/span><\/p>\r\n<\/td>\r\n<td width=\"57\">\r\n<p><span lang=\"EN-MY\">55<\/span><\/p>\r\n<\/td>\r\n<td width=\"85\">\r\n<p><span lang=\"EN-MY\">12.31 (2.49)<\/span><\/p>\r\n<\/td>\r\n<td width=\"76\">\r\n<p><span lang=\"EN-MY\">13.65 (1.99)<\/span><\/p>\r\n<\/td>\r\n<td width=\"141\">\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">1.34 (0.64, 2.05)<\/span><\/p>\r\n<\/td>\r\n<td width=\"66\">\r\n<p><span lang=\"EN-MY\">3.841 (54)<\/span><\/p>\r\n<\/td>\r\n<td width=\"77\">\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">* &lt; 0.001<\/span><\/p>\r\n<\/td>\r\n<td width=\"54\">\r\n<p><span lang=\"EN-MY\">0.518<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"85\">\r\n<p><span lang=\"EN-MY\">Control<\/span><\/p>\r\n<\/td>\r\n<td width=\"57\">\r\n<p><span lang=\"EN-MY\">56<\/span><\/p>\r\n<\/td>\r\n<td width=\"85\">\r\n<p><span lang=\"EN-MY\">12.23 (2.72)<\/span><\/p>\r\n<\/td>\r\n<td width=\"76\">\r\n<p><span lang=\"EN-MY\">13.60 (2.26)<\/span><\/p>\r\n<\/td>\r\n<td width=\"141\">\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">1.36 (0.68, 2.04)<\/span><\/p>\r\n<\/td>\r\n<td width=\"66\">\r\n<p><span lang=\"EN-MY\">3.998 (55)<\/span><\/p>\r\n<\/td>\r\n<td width=\"77\">\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">* &lt; 0.001<\/span><\/p>\r\n<\/td>\r\n<td width=\"54\">\r\n<p><span lang=\"EN-MY\">0.534<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"642\" colspan=\"8\" valign=\"top\">\r\n<p align=\"center\"><span lang=\"EN-MY\">Table 3. Intragroup comparison of pre and post MCQ scores among intervention and control groups (Paired t-test)<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td width=\"642\" colspan=\"8\" valign=\"top\">\r\n<p><span lang=\"EN-MY\">n: number of students\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 * Significant<\/span><\/p>\r\n<p><span lang=\"EN-MY\">SD: Standard deviation<\/span><\/p>\r\n<p><span lang=\"EN-MY\">95% CI: 95% confidence interval<\/span><\/p>\r\n<p><span lang=\"EN-MY\">dz: Cohen\u2019s dz<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/div>\r\n<p style=\"text-align: center;\"><span lang=\"EN-GB\"><\/span><strong><span lang=\"EN-GB\">IV. DISCUSSION<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Multiple studies have revealed slight to the modest enhancement of knowledge in simulation-based medical education (SBME) when compared to other instructional teaching methods (Cook et al., 2012; Gordon et al., 2006; Lo et al., 2011; Ray et al., 2012; Ten Eyck et al., 2009). Notwithstanding the increasing popularity of SBME, there is little evidence to conclude that it is superior to other small-group teaching modalities for the acquisition of knowledge (Alluri et al., 2016). The common perception is that knowledge lies at the lowest level of competence in Miller&#8217;s model of clinical acumen (Miller, 1990), but it is also important to note that knowledge is the basic foundation of competence and proficiency (Norman, 2009). Theoretically, SBME is advantageous for assessment of both knowledge and skills but there are few studies which directly evaluated the effectiveness of HFS in the assessment of knowledge (McGaghie et al., 2009; Rogers, 2008).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The mean scores of both Pre-test and the Post-test were higher in the intervention group in this study. In comparison, our preliminary study demonstrated that<\/span><span lang=\"EN-US\"> the control group had higher mean MCQ marks than the intervention group in Pre-test whereas at Post-test, the intervention group had higher mean MCQ marks than the control group (Pal et al., 2021).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">In our study, there is significant enhancement of knowledge (P &lt; 0.001) in both modes of teaching which corroborates the findings of <\/span><span lang=\"EN-US\">Alluri et al. (2016). Their RCT study demonstrated that the participants in both the simulation and lecture groups had improved post-test scores (p &lt; 0.05). The comparison of Pre-test and Post-test MCQ scores in our preliminary study also revealed significant higher mean MCQ scores at Post-test than Pre-test in both intervention and control groups (Pal et al., 2021). A study by Couto et al. (2015) showed improved post-test scores in both methods. Similar results were noted in the studies by Chen et al. (2017) and <\/span><span lang=\"EN-MY\">Vijayaraghavan et al. (2019)<\/span><span lang=\"EN-US\">. The finding of a study by Hall (2013) showed a slight increase in post-test scores in both the HFPS and control groups. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-US\">A systematic review by La Cerra et al. (2019) revealed that HFS was superior to other teaching methods in improving knowledge and performance. Significant higher scores for participants in the HFS group in the studies by Larsen et al. (2020) and Solymos et al. (2015) demonstrated that HFS may be superior to conventional teaching methods for factual learning. In another study by Bartlett et al. (2021), HFS showed a significant long-term gain in knowledge over traditional teaching methods, but short-term knowledge gain was insignificant. Our study revealed that the Post-test MCQ score was higher in the HFS group but after adjustment of pre-test scores, there was no significant difference in knowledge gain between the control and intervention groups. The findings were similar in our preliminary study where\u00a0 the intervention group had higher mean change score of MCQ scores than the control group but it was not statistically significant (Pal et al., 2021).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-US\">On the other hand, there was no significant knowledge improvement in both simulation and traditional teaching methods as observed in the studies (Corbridge et al., 2010; Kerr et<i> <\/i>al., 2013; Moadel et<i> <\/i>al., 2017).<\/span><span lang=\"EN-MY\"> The findings of Alluri et al. (2016) also showed <\/span><span lang=\"EN-US\">no difference in knowledge gain between simulation and lecture-based teaching. The studies by Morgan et al. (2002) and Tan et al. (2008), demonstrated equal efficacy between simulation and conventional lectures. The findings of a study by Kerr et al. (2013) demonstrated that SBME was not beneficial in acquisition and retention of knowledge. There was no significant improvement in knowledge after simulation-based education as revealed by the findings of three RCTs (<\/span><span lang=\"EN-MY\">Cavaleiro et al., 2009; <\/span><span lang=\"EN-US\">Cherry et al., 2007; Kim et al., 2002). <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Despite simulation being effective in acquisition of knowledge, it may not be the most efficient modality when compared to other traditional educational methods (Bordage et al., 2009). <\/span><span lang=\"EN-US\">There is ample evidence that SBME usually leads to enhancement of knowledge and skills among undergraduate students but its superiority over other conventional teaching methods is yet to be defined (Nestel et al., 2015).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><i><span lang=\"EN-US\">A. Limitations<\/span><\/i><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-US\">There is a possibility of potential biases in the form of design, recruitment, sample populations and data analysis that could have influenced the findings. Due to randomization in blocks of two, the allocation of participants may be predictable which may result in selection bias. The confounding factors such as communication between the different groups of students prior to the second MCQ assessment, participants\u2019 recall memory and preparation for the post-test after 7 &#8211; 8 weeks need to be considered. As it was a single-centre study which included final-year medical students only, the validity of the findings may not be applicable to other settings.<\/span><\/p>\r\n<p style=\"text-align: center;\"><span lang=\"EN-GB\"><\/span><strong><span lang=\"EN-GB\">V. CONCLUSION<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Conventional teaching modalities and HFS, when used in conjunction with bedside teaching, may complement clinical practice, leading to higher retention of knowledge. Therefore, more studies are required to measure the efficacy of simulation for a better understanding of the differences that it can make in the acquisition of knowledge. Our study revealed that the efficacy of high-fidelity simulation-based teaching was not superior to video-assisted lecture-based teaching in terms of knowledge acquisition and retention. The substantially higher cost and maintenance associated with HFS need to be considered before planning a teaching-learning activity. It may be used judiciously with conventional teaching when the objectives are mainly knowledge-based. More studies are required to determine its effectiveness and further evaluation as a teaching-learning tool in medical education.<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Notes on Contributors<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Bikramjit Pal was involved in Conceptualization, Formal Analysis, Literature Review, Methodology, Project administration &amp; Supervision, Data Analysis and Writing (original draft &amp; editing).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Aung Win Thein was involved in Formal Analysis, Literature Review, Methodology, Supervision and Writing (review &amp; editing).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Sook Vui Chong was involved in Literature Review, Methodology, Supervision and Writing (review &amp; editing).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Ava Gwak Mui Tay was involved in Formal Analysis, Literature Review, Supervision and Writing (review &amp; editing).<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Htoo Htoo Kyaw Soe was involved in Formal Analysis, Methodology, Data curation, Statistical Analysis and Validation.<\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Sudipta Pal was involved in Literature Review, Methodology, Formal Analysis, Data curation and Writing (review &amp; editing).<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Ethical Approval<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Ethical approval was duly obtained from the Ethical Committee \/ IRB of Manipal University College Malaysia. Informed consent was taken from all the participants. All information about the participants was kept confidential. <\/span><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">Approval number: MMMC\/FOM\/Research Ethics Committee &#8211; 11\/2018.<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Data Availability<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-GB\">The data that supports the findings of this RCT study are openly available at Figshare repository, <\/span><span lang=\"EN-US\"><a href=\"https:\/\/doi.org\/10.6084\/m9.figshare.19932053.v2\">https:\/\/doi.org\/10.6084\/m9.figshare.19932053.v2<\/a><\/span><span lang=\"EN-US\"> <\/span><span lang=\"EN-MY\">(Pal et al., 2022).<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Acknowledgement<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-GB\">The authors would like to acknowledge the final year MBBS students of Manipal University College Malaysia who had participated in this research project, the faculty of the Department of Surgery, the lab assistants and technicians of Clinical Skills Lab and the Management of Manipal University College Malaysia.<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Funding<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The researchers had not received any funding or benefits from industry or elsewhere to conduct this study.<\/span><\/p>\r\n<p align=\"center\" style=\"text-align: center;\"><strong><span lang=\"EN-GB\">Declaration of Interest<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify;\"><span lang=\"EN-MY\">The researchers had no conflicts of interest.<\/span><\/p>\r\n<p style=\"text-align: center;\"><strong>References<\/strong><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Accreditation Council for Graduate Medical Education. (2020, July 1). <i>Program requirements for graduate medical education in general surgery<\/i>. <\/span><span lang=\"EN-US\"><a href=\"https:\/\/www.acgme.org\/globalassets\/pfassets\/programrequirements\/440_generalsurgery_2020.pdf\">https:\/\/www.acgme.org\/globalassets\/pfassets\/programrequirements\/440_generalsurgery_2020.pdf<\/a><\/span><span lang=\"EN-MY\">.<\/span><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Alluri, R. K., Tsing, P., Lee, E., &amp; Napolitano, J. (2016). 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Lessons for continuing medical education from simulation research in undergraduate and graduate medical education: Effectiveness of continuing medical education: American College of Chest Physicians Evidence-Based Educational Guidelines. <i>Chest<\/i>, <i>135<\/i>(3 Suppl), 62S\u201368S. <\/span><a href=\"https:\/\/doi.org\/10.1378\/chest.08-2521\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.1378\/chest.08-2521<\/span><\/a><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Miller, G. E. (1990). The assessment of clinical skills\/competence\/performance. <i>Academic Medicine<\/i>, <i>65<\/i>(9), S63\u2013S67. <\/span><span lang=\"EN-US\"><a href=\"https:\/\/doi.org\/10.1097\/00001888-199009000-00045\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.1097\/00001888-199009000-00045<\/span><\/a><\/span><span><span lang=\"EN-MY\"><\/span><\/span><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Moadel, T., Varga, S., &amp; Hile, D. (2017). A prospective randomized controlled trial comparing simulation, lecture and discussion-based education of sepsis to emergency medicine residents. <i>Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health<\/i>, <i>18<\/i>(5.1). <\/span><a href=\"https:\/\/escholarship.org\/uc\/item\/0132981t\"><span lang=\"EN-MY\">https:\/\/escholarship.org\/uc\/item\/0132981t<\/span><\/a><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Morgan, P. J., Cleave-Hogg, D., McIlroy, J., &amp; Devitt, J. H. (2002). 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M., Wylie, D. R., Shaun Rowe, A., Heidel, E., &amp; Franks, A. S. (2012). Pharmacy student knowledge retention after completing either a simulated or written patient case. <i>American Journal of Pharmaceutical Education<\/i>, <i>76<\/i>(5), 86. <\/span><a href=\"https:\/\/doi.org\/10.5688\/ajpe76586\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.5688\/ajpe76586<\/span><\/a><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Rogers, D. A. (2008). The role of simulation in surgical continuing medical education<i>. Seminars in Colon and Rectal Surgery, 19<\/i>(2)<i>, <\/i>108-114.<\/span><span lang=\"EN-US\"><a href=\"https:\/\/doi.org\/10.1053\/j.scrs.2008.02.007\"><span lang=\"EN-MY\"> https:\/\/doi.org\/10.1053\/j.scrs.2008.02.007<\/span><\/a><\/span><span lang=\"EN-MY\"> <\/span><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Solymos, O., O&#8217;Kelly, P., &amp; Walshe, C. M. (2015). Pilot study comparing simulation-based and didactic lecture-based critical care teaching for final-year medical students. <i>BMC Anesthesiology<\/i>, <i>15<\/i>, Article 153. <\/span><span lang=\"EN-US\"><a href=\"https:\/\/doi.org\/10.1186\/s12871-015-0109-6\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.1186\/s12871-015-0109-6<\/span><\/a><\/span><span><span lang=\"EN-MY\"><\/span><\/span><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Tan, G. M., Ti, L. K., Tan, K., &amp; Lee, T. (2008). A comparison of screen-based simulation and conventional lectures for undergraduate teaching of crisis management. <i>Anaesthesia and Intensive Care<\/i>, <i>36<\/i>(4), 565\u2013569.<\/span><span lang=\"EN-US\"><\/span><span><span style=\"text-decoration: line-through;\"><span lang=\"EN-MY\"><\/span><\/span><\/span><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Ten Eyck, R. P., Tews, M., &amp; Ballester, J. M. (2009). Improved medical student satisfaction and test performance with a simulation-based emergency medicine curriculum: a randomized controlled trial. <i>Annals of Emergency Medicine<\/i>, <i>54<\/i>(5), 684\u2013691. <\/span><a href=\"https:\/\/doi.org\/10.1016\/j.annemergmed.2009.03.025\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.1016\/j.annemergmed.2009.03.025<\/span><\/a><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Vijayaraghavan, S., Rishipathak, P., &amp; Hinduja, A. (2019). High-fidelity simulation versus case-based discussion for teaching bradyarrhythmia to emergency medical services students. <i>Journal of Emergencies, Trauma, and Shock<\/i>, <i>12<\/i>(3), 176\u2013178. <\/span><a href=\"https:\/\/doi.org\/10.4103\/JETS.JETS_115_18\"><span lang=\"EN-MY\">https:\/\/doi.org\/10.4103\/JETS.JETS_115_18<\/span><\/a><\/p>\r\n<p style=\"text-align: left;\"><span lang=\"EN-MY\">Yang, Y., &amp; Liu, H. P. (2016). Systematic evaluation influence of high-fidelity simulation teaching on clinical competence of nursing students. <i>Chinese Nursing Research<\/i>, <i>30<\/i>(7), 809\u2013814. <\/span><span lang=\"EN-US\"><a href=\"https:\/\/caod.oriprobe.com\/articles\/47628779\/Systematic_evaluation_influence_of_high_fidelity_s.htm\"><span lang=\"EN-MY\">https:\/\/caod.oriprobe.com\/articles\/47628779\/Systematic_evaluation_influence_of_high_fidelity_s.htm<\/span><\/a><\/span><\/p>\r\n<p>*Bikramjit Pal<br \/>\r\nRCSI &amp; UCD Malaysia Campus (RUMC), <br \/>\r\n4 Jalan Sepoy Lines, <br \/>\r\nGeorgetown, Penang, 10450, Malaysia <br \/>\r\n+6042171908-1908 (Ext)<br \/>\r\nEmail: bikramjit.pal@rcsiucd.edu.my<\/p>","protected":false},"featured_media":0,"parent":0,"menu_order":2,"template":"","issues_category":[12],"archive_category":[],"issue_type":[25],"volume_category":[61877],"class_list":["post-72113","issues","type-issues","status-publish","hentry","issues_category-original-articles","issue_type-past-issue","volume_category-volume-8-number-3-july-2023"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge - The Asia Pacific Scholar<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge - The Asia Pacific Scholar\" \/>\n<meta property=\"og:description\" content=\"Submitted: 16 May 2022 Accepted: 3 January 2023 Published online: 4 July, TAPS 2023, 8(3), 5-14 https:\/\/doi.org\/10.29060\/TAPS.2023-8-3\/OA2813 Bikramjit Pal1, Aung Win Thein2, Sook Vui Chong3, Ava Gwak Mui Tay4, Htoo Htoo Kyaw Soe5 &amp; Sudipta Pal6 1Department of Surgery, Manipal University College Malaysia, Melaka, Malaysia; 2Department of Surgery, Manipal University College Malaysia, Melaka, Malaysia; 3Department [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/\" \/>\n<meta property=\"og:site_name\" content=\"The Asia Pacific Scholar\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-03T00:09:29+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"26 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/\",\"name\":\"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge - The Asia Pacific Scholar\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/taps\/#website\"},\"datePublished\":\"2023-06-26T00:48:30+00:00\",\"dateModified\":\"2023-10-03T00:09:29+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/taps\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/taps\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/taps\/\",\"name\":\"The Asia Pacific Scholar\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/taps\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge - The Asia Pacific Scholar","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicine.nus.edu.sg\/taps\/issues\/a-randomised-control-trial-study-on-the-efficacy-of-high-fidelity-simulation-in-enhancing-knowledge\/","og_locale":"en_US","og_type":"article","og_title":"A randomised control trial study on the efficacy of high-fidelity simulation in enhancing knowledge - The Asia Pacific Scholar","og_description":"Submitted: 16 May 2022 Accepted: 3 January 2023 Published online: 4 July, TAPS 2023, 8(3), 5-14 https:\/\/doi.org\/10.29060\/TAPS.2023-8-3\/OA2813 Bikramjit Pal1, Aung Win Thein2, Sook Vui Chong3, Ava Gwak Mui Tay4, Htoo Htoo Kyaw Soe5 &amp; 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