{"id":70447,"date":"2021-04-13T11:50:09","date_gmt":"2021-04-13T03:50:09","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/taps\/?post_type=issues&#038;p=70447"},"modified":"2021-07-13T09:06:58","modified_gmt":"2021-07-13T01:06:58","slug":"the-predictive-brain-model-in-diagnostic-reasoning","status":"publish","type":"issues","link":"https:\/\/medicine.nus.edu.sg\/taps\/issues\/the-predictive-brain-model-in-diagnostic-reasoning\/","title":{"rendered":"The predictive brain model in diagnostic reasoning"},"content":{"rendered":"<p style=\"text-align: justify\">Submitted: 4 August 2020<br \/>\r\nAccepted: 14 October 2020<br \/>\r\nPublished online: <span lang=\"EN-GB\">4 May, TAPS 2021, <\/span><span lang=\"EN-GB\">6(2), 1-8<\/span><br \/>\r\n<a href=\"https:\/\/doi.org\/10.29060\/TAPS.2021-6-2\/RA2370\">https:\/\/doi.org\/10.29060\/TAPS.2021-6-2\/RA2370<\/a><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Tow Keang Lim<\/span><span lang=\"EN-GB\"><\/span><\/p>\r\n<p style=\"text-align: justify\"><i><span lang=\"EN-GB\">Department of Medicine, National University Hospital, Singapore<\/span><\/i><i><span lang=\"EN-GB\"><\/span><\/i><\/p>\r\n<p style=\"text-align: center\"><b><span lang=\"EN-GB\">Abstract<\/span><\/b><\/p>\r\n<p style=\"text-align: justify\"><b><span lang=\"EN-GB\">Introduction:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">Clinical diagnosis is a pivotal and highly valued skill in medical practice. Most current interventions for teaching and improving diagnostic reasoning are based on the dual process model of cognition. Recent studies which have applied the popular dual process model to improve diagnostic performance by \u201cCognitive De-biasing\u201d in clinicians have yielded disappointing results. Thus, it may be appropriate to also consider alternative models of cognitive processing in the teaching and practice of clinical reasoning.<\/span><\/p>\r\n<p style=\"text-align: justify\"><b><span lang=\"EN-GB\">Methods:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">This is critical-narrative review of the predictive brain model.<\/span><\/p>\r\n<p style=\"text-align: justify\"><b><span lang=\"EN-GB\">Results:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">The theory of predictive brains is a general, unified and integrated model of cognitive processing based on recent advances in the neurosciences. The predictive brain is characterised as an adaptive, generative, energy-frugal, context-sensitive action-orientated, probabilistic, predictive engine. It responds only to predictive errors and learns by iterative predictive error management, processing and hierarchical neural coding.\u00a0 <\/span><\/p>\r\n<p style=\"text-align: justify\"><b><span lang=\"EN-GB\">Conclusion:<\/span><\/b><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">The default cognitive mode of predictive processing may account for the failure of de-biasing since it is not thermodynamically frugal and thus, may not be sustainable in routine practice. Exploiting predictive brains by employing language to optimise metacognition may be a way forward.<\/span><b><span lang=\"EN-GB\">\u00a0<\/span><\/b><\/p>\r\n<p style=\"text-align: justify\"><b><span lang=\"EN-GB\">Keywords<\/span><\/b><b><span lang=\"EN-GB\">:<\/span><\/b><span lang=\"EN-GB\">\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/span><i><span lang=\"EN-GB\">Diagnosis, Bias, Dual Process Theory, Predictive Brains<\/span><\/i><\/p>\r\n<p align=\"center\" style=\"text-align: center\"><strong><span lang=\"EN-GB\">Practice Highlights<\/span><\/strong><\/p>\r\n<ul>\r\n\t<li style=\"text-align: justify\"><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">According to the dual process model of cognition diagnostic errors are caused by bias reasoning.<\/span><\/li>\r\n\t<li style=\"text-align: justify\"><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">Interventions to improve diagnosis based on \u201cCognitive De-biasing\u201d methods report disappointing results.<\/span><span lang=\"EN-GB\"><\/span><\/li>\r\n\t<li style=\"text-align: justify\"><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">The predict brain is a unified model of cognition which accounts for diagnostic errors, the failure of \u201cCognitive De-biasing\u201d and may point to effective solutions.<\/span><\/li>\r\n\t<li style=\"text-align: justify\"><span lang=\"EN-GB\"> <\/span><span lang=\"EN-GB\">Using appropriate language as simple rules or thumb, to fine-tune predictive processing meta-cognitively may be a practical strategy to improve diagnostic problem solving.<\/span><\/li>\r\n<\/ul>\r\n<div>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">I. <\/span><span lang=\"EN-GB\">INTRODUCTION<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Clinical diagnostic expertise is a critical, highly valued, and admired skill (Montgomery, 2006). However, diagnostic errors are common and important adverse events which merit research and effective prevention (Gupta et al., 2017; Singh et al., 2014; Skinner et al., 2016). Thus, it is now widely acknowledged and recognized that concerted efforts are required to improve the research, training and practice of clinical reasoning in improving diagnosis (Simpkin et al., 2017; Singh &amp; Graber, 2015; Zwaan et al., 2013). The consensus among practitioners, researchers and preceptors is that most preventable diagnostic errors are associated with bias reasoning during rapid, non-analytical, default cognitive processing of clinical information (Croskerry, 2013). The most widely held theory which accounts for this observation is the dual process model of cognition (B. Djulbegovic et al., 2012; Evans, 2008; Schuwirth, 2017). It posits that most diagnostic errors reside in intuitive, non-analytical or systems 1 thinking (Croskerry, 2009). Thus, the logical, practical and common sense implication which follows from this assumption is that we should activate and apply analytical or system 2 thinking to counter-check or \u201cDe-bias\u201d system 1 errors (Croskerry, 2009). This is a popular notion and it has facilitated the emergence of many schools of clinical reasoning based on training methods designed to deliberately understand, recognise, categorise and avoid specific diagnostic errors arising from system thinking 1 or cognitive bias (Reilly et al., 2013; Rencic et al., 2017; Restrepo et al., 2020). However, careful research on the merits of these interventions under controlled conditions do not show consistent nor clear benefits (G. Norman et al., 2014; G. R. Norman et al., 2017; O&#8217;Sullivan &amp; Schofield, 2019; Sherbino et al., 2014; Sibbald et al., 2019; J. N. Walsh et al., 2017). Moreover, even the recognition and categorization of these cognitive error events themselves are deeply confounded by hindsight bias itself (Zwaan et al., 2016). Perhaps, at this juncture, it might be appropriate to consider alternative models of cognition based on advances in multi-disciplinary neuroscience research which have expanded greatly in recent years (Monteiro et al., 2020).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Over the past decade the theory of predictive brains has emerged as an ambitious, unified, convergent and integrated model of cognitive processing from research in a large variety of core domains in cognition which include philosophy, meta-physics, cellular physics, thermodynamics, Associative Learning theory, Bayesian-probability theory, Information theory, machine learning, artificial intelligence, behavioural science, neuro-cognition, neuro-imaging, constructed emotions and psychiatry (Bar, 2011; Barrett, 2017a; Barrett, 2017b; Clark, 2016; Friston, 2010; Hohwy, 2013; Seligman, 2016; Teufel &amp; Fletcher, 2020). It may have profound and practical implications on how we live, work and learn. However, to my knowledge, there is almost no discussion of this novel proposition in either medical education pedagogy or research. Thus, in this presentation I will review recent developments in the predictive brain model of cognition, map its key elements which impacts on pedagogy and research in medical education and propose an application in the training of diagnostic reasoning based on it. <\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">An early version of this work had been presented as an abstract (Lim &amp; Teoh, 2018).<\/span><\/p>\r\n<p style=\"text-align: center\"><strong><span lang=\"EN-GB\">II. METHODS<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">This is a critical-narrative review of the predictive brain model from Friston\u2019s \u201cThe free energy principle\u201d proposition a decade ago to more recent critical examination of the emerging supportive evidence based on neurophysiological studies over the past 5 years (Friston, 2010; K. S. Walsh et al., 2020).<\/span><\/p>\r\n<p style=\"text-align: center\"><strong><span lang=\"EN-GB\">III. RESULTS<\/span><\/strong><\/p>\r\n<p><i><span lang=\"EN-GB\">A. The Brain is a Frugal Predictive Engine<\/span><\/i><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">The Brain Is A Frugal Predictive Engine (General references (Bar, 2011; Barrett, 2017a; Barrett, 2017b; Clark, 2013; Clark, 2016; Friston, 2010; Gilbert &amp; Wilson, 2007; Hohwy, 2013; Seligman, 2016; Seth et al., 2011; Sterling, 2012).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">In contrast with traditional top-down, feed-forward models of cognition, the predictive brain model reverses and inverts this process. Perception is characterised as an entirely inferential rapidly adaptive, generative, energy-frugal, context-sensitive action-orientated, probabilistic, predictive process (Tschantz et al., 2020). This system is governed by the need to respond rapidly to ever changing demands from the external environmental and our body\u2019s internal physiological signals (intero-ception) and yet minimise free energy expenditure (or waste) (Friston, 2010; Kleckner et al., 2017; Sterling, 2012). Thus, it is not passive and reactive to new information but predictive and continuously proactive. From very early, elemental and sparse cues it is continuously generating predictive representations based on remembered similar experiences in the past which may include simulations. It performs iterative matching of top down prior representations with bottom up signals and cues in a hierarchy of categories of abstractions and content specificity over scales of space and time (Clark, 2013; Friston &amp; Kiebel, 2009; Spratling, 2017a). This matching process is also sensitive to variations in context and thus enable us to make sense of rapidly changing and complex situations (Clark, 2016). <\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Cognitive resource, in terms of allocating attention, is only focused on the management of errors in prediction or the mismatch between prior representations and new emergent information. It seeks to minimise prediction errors (PEs) and there is repetitive, recognition-expectation-based signal suppression when this is achieved. Thus, this is a system which only responds to the unfamiliar situation or what it considers as news worthy. This is analogous to Claude Shannons\u2019s classic analysis of \u201csurprisals\u201d in information theory (Shannon et al., 1993). Learning is based on the generation and neural coding of a new predictive representations in memory. The most direct and powerful evidence for this process comes from optogenetic experiments with their exquisitely high degree of resolution in the monitoring and manipulations over space-time of neuronal signalling and behaviour in freely forging rats which show causal linkages between PE, dopamine neurons and learning (Nasser et al., 2017; Steinberg et al., 2013).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">The brain intrinsically generates representations of the world in which it finds itself from past experience which is refined by sensory data. New sensory information is represented and inferred in terms of these known causes. Determining which combination of the many possible causes best fits the current sensory data is achieved through a process of minimising the error between the sensory data and the sensory inputs predicted by the expected causes, i.e. the PE. In the service of PE reduction, the brain will also generate motor actions such as saccadic eye movement and foraging behaviour. The prediction arises from a process of \u201cbackwards thinking\u201d or inferential Bayesian best guess or approximation based simultaneously on sensory data and prior experience (Chater &amp; Oaksford, 2008; Kersten et al., 2004; Kwisthout et al., 2017a; Kwisthout et al., 2017b; Ting et al., 2015). It is a hierarchical predictive coding process, reflecting the serial organization of the neuronal architecture of cerebral cortex; higher levels are abstract, whereas the lowest level amounts to a prediction of the incoming sensory data (Kolossa et al., 2015; Shipp, 2016; Ting et al., 2015). The actual sensory data is compared to the predicted sensory data, and it is the discrepancies, or \u2018error\u2019 that ascends up the hierarchy to refine all higher levels of abstraction in the model. Thus, this is a learning process whereby, with each iteration, the model representations are optimised and encoded in long term memory as the PEs minimise (Friston, FitzGerald, Rigoli et al., 2017; Spratling, 2017b).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">This system of neural responses is regulated and fine-tuned by varying the gains on the weightage of the reliability (or precision) of the PE estimate itself. In other words, it is the level of confidence (versus uncertainty) in the PE which determines the intensity of attention allocated to it and strength of coding in memory following its resolution (Clark, 2013; Clark, 2016; Feldman &amp; Friston, 2010; Hohwy, 2013). This regulatory, neuro-modulatory process is impacted by the continuous cascade of action relevant information which is sensitive to both external context and internal interoceptive (i.e. from perception of our own physiological responses) and affective signals (Clark, 2016). This metacognitive capacity to effectively manipulate and re-calibrate the precision of PE itself may be a critical aspect of decision making, problem solving behaviour and learning. (Hohwy, 2013; Picard &amp; Friston, 2014).<\/span><\/p>\r\n<p style=\"text-align: left\"><i><span lang=\"EN-GB\">B. Clinical Reasoning is Predictive Error Processing <\/span><\/i><i><span lang=\"EN-GB\">and Learning is Predictive Coding<\/span><\/i><\/p>\r\n<p align=\"left\" style=\"text-align: left\"><span lang=\"EN-GB\">The core processes of the predictive brain which are engaged during diagnostic reasoning are summarised in Table 1 and Figure 1.<\/span><\/p>\r\n<\/div>\r\n<table border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\r\n<tbody>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Core features of the predictive brain model<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Clinical reasoning features and processes<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>The frugal brain and free energy principle(<a href=\"#_ENREF_23\" title=\"Friston, 2010 #37\">Friston, 2010<\/a>)<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Cognitive load in problem solving (<a href=\"#_ENREF_76\" title=\"Young, 2014 #115\">Young et al., 2014<\/a>)<\/p>\r\n<p><span lang=\"EN-GB\">\u00a0<\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Iterative matching of top down priors Vs bottom up signals<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Inductive foraging (<a href=\"#_ENREF_17\" title=\"Donner-Banzhoff, 2014 #242\">Donner-Banzhoff &amp; Hertwig, 2014<\/a>; <a href=\"#_ENREF_18\" title=\"Donner-Banzhoff, 2017 #241\">Donner-Banzhoff et al., 2017<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Predictive error processing<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Pattern recognition in diagnosis<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Recognition-expectation-based signal suppression\u00a0\u00a0 <span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Premature closure (<a href=\"#_ENREF_6\" title=\"Blissett, 2017 #86\">Blissett &amp; Sibbald, 2017<\/a>; <a href=\"#_ENREF_39\" title=\"Melo, 2017 #29\">Melo et al., 2017<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Hierarchical predictive error coding as learning<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Development of illness scripts (<a href=\"#_ENREF_14\" title=\"Custers, 2014 #174\">Custers, 2014<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Probabilistic-Bayesian inferential approximations \u00a0\u00a0 <span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Bayesian inference in clinical reasoning<span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Context sensitivity\u00a0\u00a0 <span lang=\"EN-GB\"><\/span><\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Contextual factors in diagnostic errors(<a href=\"#_ENREF_19\" title=\"Durning, 2010 #68\">Durning et al., 2010<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Action orientation\u00a0\u00a0\u00a0<\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Foraging behaviour in clinical diagnosis (<a href=\"#_ENREF_17\" title=\"Donner-Banzhoff, 2014 #242\">Donner-Banzhoff &amp; Hertwig, 2014<\/a>; <a href=\"#_ENREF_18\" title=\"Donner-Banzhoff, 2017 #241\">Donner-Banzhoff et al., 2017<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Interoception and affect in prediction error management\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Gut feel and regret (metacognition)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<tr>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>The precision(reliability\/uncertainty) of prediction errors<\/p>\r\n<\/td>\r\n<td valign=\"top\" style=\"width: 325px\">\r\n<p>Clinical uncertainty (metacognition) (<a href=\"#_ENREF_5\" title=\"Bhise, 2017 #71\">Bhise et al., 2017<\/a>; <a href=\"#_ENREF_59\" title=\"Simpkin, 2016 #70\">Simpkin &amp; Schwartzstein, 2016<\/a>)<\/p>\r\n<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<p align=\"center\">Table 1: Core features of the predictive brain model of cognition manifested as clinical reasoning processes<\/p>\r\n<p align=\"center\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"770\" src=\"https:\/\/medicine.nus.edu.sg\/taps\/wp-content\/uploads\/sites\/10\/2021\/03\/RA2370-Figure-1-1024x770.jpg\" alt=\"\" class=\"alignnone size-large wp-image-70448\" srcset=\"https:\/\/medicine.nus.edu.sg\/taps\/wp-content\/uploads\/sites\/10\/2021\/03\/RA2370-Figure-1-1024x770.jpg 1024w, https:\/\/medicine.nus.edu.sg\/taps\/wp-content\/uploads\/sites\/10\/2021\/03\/RA2370-Figure-1-300x226.jpg 300w, https:\/\/medicine.nus.edu.sg\/taps\/wp-content\/uploads\/sites\/10\/2021\/03\/RA2370-Figure-1-768x578.jpg 768w, https:\/\/medicine.nus.edu.sg\/taps\/wp-content\/uploads\/sites\/10\/2021\/03\/RA2370-Figure-1.jpg 1102w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/p>\r\n<p style=\"text-align: justify\">Legend to Figure 1<\/p>\r\n<p style=\"text-align: justify\">A summary of the cognitive processes engaged by the predict brain model during clinical diagnosis<\/p>\r\n<p style=\"text-align: justify\">A: Active search for diagnostic clues based on prior experience of similar patients in similar situations.<\/p>\r\n<p style=\"text-align: justify\">B: Recognition of key features will activate a series of familiar illness script from long term memory to match with the new case.\u00a0 If this is successful, a diagnosis made and any prediction error signals are rapidly silenced.<\/p>\r\n<p style=\"text-align: justify\">C &amp; D: When the illness scripts do not match the presenting features (????), cognition slows down, attention is heightened and further searches are made for additional matching clues and illness scripts. This is iterated \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 until a satisfactory match is found or a new illness script is generated to account for the mismatch.<\/p>\r\n<p style=\"text-align: justify\">E: A new variation in the presenting features for that disease is then encoded in memory as a new illness script in memory and thus, a valuable learning moment.<\/p>\r\n<p style=\"text-align: justify\">F: The degree of uncertainty or level of confidence in matching key presenting features to a diagnosis is a meta-cognitive skill and a critical expertise in clinical diagnosis. This corresponds to the precision or gain\/weightage of prediction errors (Meta cognition) in the predictive brain model.<\/p>\r\n<p align=\"center\" style=\"text-align: center\">Figure 1: A summary of the cognitive processes engaged by the predict brain model during clinical diagnosis<\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Thermodynamic frugality is a central feature of the predictive brain model and in this system, the primacy of attending only to surprises or PEs is pivotal (Friston, 2010). This might be regard as an energy efficient strategy in coping with cognitive load which has been long recognised as an important consideration in clinical problem solving and learning (Young et al., 2014; Van Merrienboer &amp; Sweller, 2010).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">From the first moments of a diagnostic encounter the clinician is alert to clues which might point to the diagnosis and begins to generate possible diagnosis scenarios and simulations based upon her prior experience of similar patients and situations (Donner-Banzhoff &amp; Hertwig, 2014). This is iterative and, from a scanty set of presenting features, a plausible diagnosis may be considered within a few seconds to minutes (Donner-Banzhoff &amp; Hertwig, 2014; Donner-Banzhoff et al., 2017). Thus, a familiar illness script is activated from long term memory to match with the new case (Custers, 2014). If this is successful, a particular diagnosis is recognised and any PE signal is rapidly silenced. Functional MRI studies of clinicians during this process showed that highly salient diagnostic information, reducing uncertainty about the diagnosis, rapidly decreased monitoring activity in the frontoparietal attentional network and may contribute to premature diagnostic closure, an important cause of diagnostic errors (Melo et al., 2017). This may be considered a form of diagnosis or recognition related PE signal suppression analogous to the well know phenomenon of repetitive suppression (Blissett &amp; Sibbald, 2017; Bunzeck &amp; Thiel, 2016; Krupat et al., 2017).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">In cases where the illness scripts do not match the presenting features, a PE event is encountered, cognition slows down, attention is heightened and further searches are made for additional matching clues and illness scripts (Custers, 2014). This is iterated until a satisfactory match is found or a new illness script is generated to account for the mismatch. This is then encoded in memory as a new variation in the presenting features for that disease and thus, a valuable learning moment. Bayesian inference is a fundamental feature of both clinical diagnostic reasoning and the predictive brain model (Chater &amp; Oaksford, 2008).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">As in the predictive brain model, external contextual factors and internal emotional and physiological responses such as gut feeling and regret, exert profound effects on clinical decision making (M. Djulbegovic et al., 2015; Durning et al., 2010; Stolper &amp; van de Wiel, 2014; Stolper et al., 2014). Also active inductive foraging behaviour in searching for diagnostic clues described in experienced primary physicians is analogous to behaviour directed at reducing PEs (Donner-Banzhoff &amp; Hertwig, 2014; Donner-Banzhoff et al., 2017). The precision or gain\/weightage of PEs is manifested metacognitively as uncertainties or levels of confidence in clinical reasoning (<\/span>Sandved-Smith et al.,<span lang=\"EN-GB\"> 2020). Metacognition is a critical capacity and expertise in effective decision making. (Bhise et al., 2017; Fleming &amp; Frith, 2014; Simpkin &amp; Schwartzstein, 2016).<\/span><\/p>\r\n<p style=\"text-align: justify\"><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-GB\">C. Why Applying the Dual Process Model May Not <\/span><\/i><i><span lang=\"EN-GB\">Improve Clinical Reasoning<\/span><\/i><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Recent studies which have applied the popular dual process model to improve diagnostic performance by \u201ccognitive de-biasing\u201d in clinicians have yielded disappointing results (G. R. Norman et al., 2017). Cognitive processing of the predictive brain as the dominant default network mode of operation may account for this setback since de-biasing is not naturistic, requires retrospective \u201coff line\u201d processing after the monitoring salience network has already shut off (Krupat et al., 2017; Melo et al., 2017). It is not thermodynamically frugal and thus, may not be sustainable in routine practice (Friston, 2010; Young et al., 2014). Even Daniel Kahneman himself admits that, despite decades of research in cognitive bias he is unable to exert agency of the moment and de-bias himself (Kahneman, 2013). This will be more so in novice diagnosticians in the training phase who have scanty illness scripts and limited tolerance of any further cognitive loading (Young et al., 2014). The failure to even identify cognitive biases reliably by clinicians due to hindsight bias itself suggests that this intervention will be the least effective one in improving diagnostic reasoning (Zwaan et al., 2016).<\/span><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\"><em>\u00a0D.<\/em> <\/span><i><span lang=\"EN-GB\"><\/span><\/i><i><span lang=\"EN-GB\">Using Words to Fine Tune the Precision of <\/span><\/i><i><span lang=\"EN-GB\">Diagnostic Prediction Error<\/span><\/i><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">Daniel Kahneman, the foremost expert on cognitive bias, cautions that, contrary to what some experts in medical education advice, avoiding bias is ineffective in improving decision making under uncertainty (Restrepo et al., 2020). By contrast he suggested that we apply simple, common sense, rules of thumb (Kahneman et al., 2016). I hypothesise that instructing clinical trainees to use appropriate words to self in the diagnostic setting during active, naturalistic PE processing before the diagnosis is made and not as a retrospective counter check to cognition afterwards may be a way forward (Betz et al., 2019; Clark, 2016; Lupyan, 2017). In a multi-center, iterative thematic content analysis of over 2,000 cases of diagnostic errors with a structured taxonomy, Schiff and colleagues identified a limited number of pitfall themes which were overlooked and predisposed physicians to reasoning errors (Reyes Nieva H et al., 2017). These pitfall themes included three which are of particular interest in relation to naturalistic PE processing namely: (1) counter diagnostic cues, (2) things that do not fit and (3) red flags (Reyes Nieva H et al., 2017). Thus, we instructed our student interns and internal medicine residents to pay particular attend to these three diagnostic pitfalls during review of new patients and clinical problems (Lim &amp; <\/span>Teoh<span lang=\"EN-GB\">, 2018). They were required to append the following sub-headings to their clerking impression in the patient\u2019s electronic health record (eHR): (a) Counter diagnostic features; (b) Things that do not fit; (c) Red flags. This template was added after the resident had entered his or her numerated list of diagnoses or issues. \u201cCounter diagnostic features\u201d was defined as symptoms, signs or investigations which were inconsistent with the proposed primary diagnosis. \u201cThings that do not fit\u201d was defined as any finding that could not be reasonably accounted for taking into account the main and differential diagnoses. \u201cRed flags\u201d were defined as findings which raised the possibility of a more serious underlying illness requiring early diagnosis or intervention. The attending physicians were required, during bedside rounds, to give feedback on these points and make amendments to the eHR as appropriate. This exercise may give us an opportunity to see if we can improve diagnostic accuracy by using pivotal words-to-self in the appropriate setting to maintain cognitive openness, flexibility and thus, avoid premature (Krupat et al., 2017). It is also a valuable critical, metacognitive thinking habit to inculcate in tyro diagnosticians (Carpenter et al., 2019).<\/span><\/p>\r\n<p style=\"text-align: center\"><span lang=\"EN-GB\"><\/span><strong><span lang=\"EN-GB\">IV. CONCLUSION<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify\"><span lang=\"EN-GB\">The theory of predictive brains has emerged as a major narrative in the understanding of how our mind works. It may account for the limitations of interventions designed to improve diagnostic problem solving which are based on the dual process theory of cognition. Exploiting predictive brains by employing language to optimise metacognition may be a way forward.<\/span><\/p>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">Note on Contributor<\/span><\/strong><\/p>\r\n<p><span lang=\"EN-GB\">Lim designed the paper, reviewed the literature, drafted and revised it.<\/span><\/p>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">Ethical Approval<\/span><\/strong><\/p>\r\n<p><span lang=\"EN-GB\">There is no ethical approval associated with this paper.<\/span><\/p>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">Funding<\/span><\/strong><\/p>\r\n<p><span lang=\"EN-GB\">No funding sources are associated with this paper.\u00a0 <\/span><\/p>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">Declaration of Interest<\/span><\/strong><\/p>\r\n<p><span lang=\"EN-GB\">No conflicts of interest are associated with this paper.\u00a0 <\/span><\/p>\r\n<p align=\"center\"><strong><span lang=\"EN-GB\">References<\/span><\/strong><\/p>\r\n<p style=\"text-align: justify\">Bar, M. 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A vignette study to assess recognition of cognitive biases in clinical case workups. <i>BMJ Quality &amp; Safety<\/i>.<i> <\/i><i>26<\/i>(2), 104\u2013110. <a href=\"https:\/\/doi.org\/10.1136\/bmjqs-2015-005014\">https:\/\/doi.org\/10.1136\/bmjqs-2015-005014<\/a><\/p>\r\n<p style=\"text-align: justify\">Zwaan, L., Schiff, G. D., &amp; Singh, H. (2013). Advancing the research agenda for diagnostic error reduction. <i>BMJ Quality &amp; Safety, 22 Suppl 2<\/i>, ii52-ii57. <a href=\"https:\/\/doi.org\/10.1136\/bmjqs-2012-001624\">https:\/\/doi.org\/10.1136\/bmjqs-2012-001624<\/a><span lang=\"EN-GB\"><\/span><\/p>\r\n<p>*Lim Tow Keang<br \/>\r\nDepartment of Medicine\u00a0<br \/>\r\nNational University Hospital<br \/>\r\n5 Lower Kent Ridge Rd<br \/>\r\nSingapore 119074<br \/>\r\nEmail: <span lang=\"EN-GB\">mdclimtk@nus.edu.sg<\/span><\/p>","protected":false},"featured_media":0,"parent":0,"menu_order":1,"template":"","issues_category":[16],"archive_category":[],"issue_type":[25],"volume_category":[61866],"class_list":["post-70447","issues","type-issues","status-publish","hentry","issues_category-review-article","issue_type-past-issue","volume_category-volume-6-number-2-may-2021"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The predictive brain model in diagnostic reasoning - The Asia Pacific Scholar<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/taps\/issues\/the-predictive-brain-model-in-diagnostic-reasoning\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The predictive brain model in diagnostic reasoning - The Asia Pacific Scholar\" \/>\n<meta property=\"og:description\" content=\"Submitted: 4 August 2020 Accepted: 14 October 2020 Published online: 4 May, TAPS 2021, 6(2), 1-8 https:\/\/doi.org\/10.29060\/TAPS.2021-6-2\/RA2370 Tow Keang Lim Department of Medicine, National University Hospital, Singapore Abstract Introduction: Clinical diagnosis is a pivotal and highly valued skill in medical practice. 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