{"id":7509,"date":"2026-01-06T08:44:27","date_gmt":"2026-01-06T00:44:27","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/phys\/?page_id=7509"},"modified":"2026-01-21T14:15:00","modified_gmt":"2026-01-21T06:15:00","slug":"publications-2026","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/phys\/research\/publications-2026\/","title":{"rendered":"Latest Publications"},"content":{"rendered":"\n<h1>\n\t\tPublications &#8211; 2026\n\t<\/h1>\n\t\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/publications-2025\/\" target=\"_self\">\n\t\t\t\t\t\t\t2026\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/publications-2025\/\" target=\"_self\">\n\t\t\t\t\t\t\t2025\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/publications-2024\/\" target=\"_self\">\n\t\t\t\t\t\t\t2024\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2023\/\" target=\"_self\">\n\t\t\t\t\t\t\t2023\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2022\/\" target=\"_self\">\n\t\t\t\t\t\t\t2022\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2021\/\" target=\"_self\">\n\t\t\t\t\t\t\t2021\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2020\/\" target=\"_self\">\n\t\t\t\t\t\t\t2020\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2019\/\" target=\"_self\">\n\t\t\t\t\t\t\t2019\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/latest-publications\/publications-2018\/\" target=\"_self\">\n\t\t\t\t\t\t\t2018\n\t\t\t\t\t<\/a>\n\t<table>\n<tbody>\n<tr>\n<td>\n<h1>DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional neural stem cells via the SWI\/SNF-E2F axis<\/h1>\n<\/td>\n<\/tr>\n<tr>\n<td>Liang Y, Grinchuk OV, Cipta NO, Zeng Y, Chuah YH, Yoon J, Khong ZJ, Chow HY, Ng W, Ong CT, Ling SC, Ng SY, Loh YH, <strong>Ong DST<\/strong>.<\/td>\n<\/tr>\n<tr>\n<td><a href=\"http:\/\/10.1126\/sciadv.ady5905\">Sci Adv<\/a><\/td>\n<\/tr>\n<tr>\n<td>Abstract<\/td>\n<\/tr>\n<tr>\n<td>Impaired neural stem cell (NSC) proliferation\/activation is associated with brain aging, but the underlying mechanisms remain poorly understood. Here, we unexpectedly find that DMTF1, a transcription factor that regulates the Arf\/p53 axis in cancer, is down-regulated in the NSCs of a premature aging model driven by telomerase deficiency. DMTF1 up-regulation was able to rescue the impaired proliferation of telomere dysfunctional NSCs. Mechanistically, DMTF1 regulates the transcription of Arid2 and Ss18 genes, two subunits of the SWI\/SNF complexes that mediate H3K27ac at E2F gene promoters to promote NSC proliferation. Accordingly, Arid2 or Ss18 depletion phenocopies DMTF1 loss in reducing H3K27ac levels, expression of E2F target genes, and NSC proliferation. Thus, our study has identified DMTF1 as a potential therapeutic target to reverse the proliferation defect of aged NSC that is modeled by telomere attrition and unearthed a distinct genetic program controlled by DMTF1 in NSC.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table>\n<tbody>\n<tr>\n<td>\n<h1 data-test=\"article-title\" data-article-title=\"\">CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies<\/h1>\n<\/td>\n<\/tr>\n<tr>\n<td><strong>Chong, S.J.F.,<\/strong> Valentin, R., Wang, J.\u00a0<i>et al.<\/i><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/doi.org\/10.1186\/s13045-025-01774-3\">J Hematol Oncol <\/a><\/td>\n<\/tr>\n<tr>\n<td>Abstract<\/td>\n<\/tr>\n<tr>\n<td>Immune checkpoint blockade of CD47 has shown promising results in lymphoid malignancies, with its effects attributed to enabling tumor-cell phagocytosis. However, alternate cytotoxic cell death mechanisms have been reported, potentially contributing to the overall anti-tumor activity. Although previous studies have highlighted a mechanism of caspase-independent cell death, this mechanism has yet to be well-characterized, thereby warranting further investigation to comprehensively understand the anti-tumor mechanism of CD47 blockade to facilitate optimal drug partner selection for combination therapy.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n","protected":false},"excerpt":{"rendered":"<p>Publications &#8211; 2026 2026 2025 2024 2023 2022 2021 2020 2019 2018 DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional [&hellip;]<\/p>\n","protected":false},"author":9465,"featured_media":0,"parent":59,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-7509","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Latest Publications - NUS Department of Physiology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/phys\/research\/publications-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Latest Publications - NUS Department of Physiology\" \/>\n<meta property=\"og:description\" content=\"Publications &#8211; 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