MAIN PUBLICATIONS

• L. Wang, Y. Tang, Y. Shi, S. Deng, G. Lu, J. Zhang, Y. Ren, Y. Wu, C. Wang, B. Bay, K. Lim, Y. Liou, R. J. Youle, C.T. Yap, H.M. Shen (2017). PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy. Nature. Submitted.

• S.S. Singh, S.Vats, A.Y. Chia, T.Z. Tan, S. Deng, M.S. Ong, F. Arfuso, C.T. Yap, B.C. Goh, G. Sethi, R. Huang, H.M. Shen, and R. Manjithaya, A.P. Kumar* (2017). Dual Role of Autophagy in Hallmarks of Cancer. Oncogene. 29 Sep 2017; 37(9):1142-1158.

• M.S. Ong, W. Cai, Y. Yuan, H.C. Leong, T.Z. Tan, A. Mohammad, M.L. You, F. Arduso, B.C. Goh, S. Warrier, G. Sethi, N.S. Tolwinski, P.E. Lobie, C.T. Yap, S.C. Hooi, R.Y. Huang, A.P. Kumar* (2017). “Lnc”-ing Wnt in female reproduction cancers: therapeutic potential of long non-coding RNAs in Wnt Signaling. Br. J. Pharmacol. 174(24):4684-4700.

• Z.X. Ng, M.S. Ong, T. Jegadeesan, S. Deng*, C.T. Yap* (2017). Breast Cancer: Exploring the Facts and Holistic Needs during and beyond Treatment. Healthcare. 2017, 5, 26.

• W. Cai , Z.X. Chen, G. Rane, S.S. Singh, Z. Choo, Z.C. Wang, Y. Yuan, T. Zea Tan, F. Arfuso, C.T. Yap, L.S. Pongor, H. Yang, M.B. Lee, B. Cher Goh, G. Sethi, T. Benoukraf, V. Tergaonkar, A.P. Kumar* (2017). Wanted DEAD/H or Alive: Helicases winding up in cancers. Journal of the National Cancer Institute. 2017 Jan 25; 109(6): djw278.

• S. Deng, M.S. Ong, Z.X Ng, T. Jegadeesan, J.B.Y. So, A. P. Kumar, C.T. Yap* (2016). Gelsolin: A new insight of its role on gastric cancer dissemination. RNA Dis. 2016; 3:e1439.

• S.Y. Loo, J.L. Hirpara, V.K. Pandey, T.Z. Tan, C.T. Yap, B.C. Goh, J.P. Thiery, P.E. Lobie, S. Pervaiz*, M. Veronique Clement*, A.P. Kumar* (2016). Manganese Superoxide Dismutase Expression Regulates the Switch Between an Epithelial and a Mesenchymal-Like Phenotype in Breast Carcinoma. Antioxidant and Redox Signaling. , 2016 Aug 20; 25(6): 283–299.

• L. Tochhawng, S. Deng, G. Pugalenthi, A.P. Kumar, K.H. Lim, H. Yang, S.C. Hooi, Y.C. Goh, S.K. Maciver, S. Pervaiz*, C.T. Yap* (2016). Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion. Oncotarget. 2016 July 6; 7(33):52832-52848.

• B.H. Huang, S. Deng, S.Y. Loo, A. Datta, Y.L. Yap, B. Yan, C.H. Ooi, T.D. Dinh, J. Zhuo, L. Tochhawng, S. Gopinadhan, T. Jegadeesan, P. Tan, M. Salto-Tellez, W.P. Yong, R. Soong, K.G. Yeoh, Y.C. Goh, P.E. Lobie, H. Yang, A.P. Kumar, S.K. Maciver, J.B. So*, C.T. Yap* (2016). Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma. Oncotarget. 2016 April 5; 7(18):25391-407.

• C. Xie, V.V. Subhash, A. Datta, N. Liem, S.H. Tan, M.S. Yeo, W.L.Tan, V. Koh, F.L. Yan, F.Y. Wong, W.K. Wong, J. So, I.B. Tan, N. Padmanabhan, C.T. Yap, P. Tan, L.K. Goh, W.P. Yong (2016). Melanoma associated antigen (MAGE)-A3 promotes cell proliferation and chemotherapeutic drug resistance in gastric cancer. Cell Oncol. 2016 April; 39(2):175-86.

• S.Y. Ler, C.H.W. Leung, L.W. Khin, G-D. Lu, M. Salto-Tellez, M. Hartman, P.T.C. Lau, C. T. Yap*, S.C. Hooi* (2015). HDAC1 and HDAC2 independently predict mortality in hepatocellular carcinoma by a competing risk regression model in a Southeast Asian population. Oncology Reports. 34, 2238-2250.

• W. Cai, C. Wan, J.N. Goh, S.Y. Loo, C.T. Yap*, A.P. Kumar* (2015). DEAD-box RNA helicases: the microRNA managers of breast cancer. RNA & Disease. 2015; 2: e846.

• J.N. Goh, S.Y. Loo, A. Datta, K.S. Siveen, W.N. Yap, W.P. Cai, E.M. Shin, C. Wang, J.E. Kim, M. Chan, A.M. Dharmarajan, A. S-G. Lee, P.E. Lobie, C.T. Yap*, A.P. Kumar* (2015). MicroRNAs in breast cancer: regulatory roles governing the hallmarks of cancer. Biological Reviews. 2015 Jan 28; 91(2):409-28.

• C.W. Fhu, A.M. Graham, C.T. Yap, S. Al-Saham, A. Castella, S.M. Chong, Y-C Lim (2014). Reed Sternberg cell-derived lymphotoxin- activates endothelial cells to enhance T cell recruitment in classical Hodgkin lymphoma. Blood. 2014 Nov 6; 124(19): 2973-82.

• E.M. Shin, H.S. Hay, M.H. Lee, J.N. Goh, T.Z. Tan, Y.P. Sen, S.W. Lim, E.M. Yousef, H.T. Ong, A.A. Thike, X.G. Kong, Z.S. Wu, E. Mendoz, W. Sun, M. Salto-Tellez, C.T. Lim, P.E. Lobie, Y.P. Lim, C.T. Yap, Q. Zeng, G. Sethi, M.B. Lee, P. Tan, B.C. Goh, L.D. Miller, J.P. Thiery, T. Zhu, L. Gaboury, P.H. Tan, K.M. Hui, G.W-C. Yip, S. Miyamoto, A.P. Kumar*, V. Tergaonkar* (2014). DEAD-box helicase, DP103, required for SUMOylation of NEMO and NF-B activation defines metastatic potential of human breast cancer. Journal of Clinical Investigation. 2014 Sep 2; 124(9) 3807-3824.

• A. Datta, S.Y. Loo, B.H. Huang, L.K. Wong, S.S.L. Tan, T.Z. Tan, S-C. Lee, J.P. Thiery, Y.C. Lim, W.P. Yong, Y.L. Lam*, A.P. Kumar*, C.T. Yap* (2014). Sphingosine kinase 1 regulates proliferative and survival responses in triple-negative breast cancer. Oncotarget. 2014 March; 5(15):5920-33.

• S.S.L. Tan, L.W. Khin, L.K. Wong, B. Yan, C.W. Ong, A. Datta, M. Salto-Tellez, Y.L. Lam, C.T. Yap* (2014). Sphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South Asian population. Clinical and Translational Gastroenterology. 2014 Feb 27; 5: e51.

• C.T. Yap* (2014). Evasive mechanisms in cancer cells pose challenges to effective therapy and prevention of cancer recurrence. Editorial, Clinical and Experimental Pharmacology. 4:e129.

• S.Y.Y. Low, Y.K. Ho, H.P Too, C.T. Yap, W.H. Ng (2013). MicroRNA as potential modulators in chemoresistant high-grade gliomas. Journal of Clinical Neuroscience. 2014 March, 21(3):395-400.

• L. Tochhawng, D. Shuo, S. Pervaiz, C.T. Yap* (2013). Redox regulation of cancer cell migration and invasion. Mitochondrion. 2013 May; 13(2):246-53.

• B.H. Huang, J.L. Zhuo, C.H.W. Leung, J.J. Liu, G.D. Lu, C.T. Yap*, S.C. Hooi* (2012). PRAP1 is a novel executor of p53-dependent mechanisms of cell survival after DNA damage. Cell Death and Disease. 2012, Dec 13; 3:e442.

• Z. Jingli, T. Ee Hong, Y. Benedict, J. Manikandan, T. Hwee Kee , K.M. Sutherland, S.C Hooi, M. Salto-Tellez, A.P. Kumar, Y.C. Goh, Y.C. Lim*, C.T. Yap* (2012). Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase plasminogen activator cascade. PLoS One. Aug 2012; 7(8): e43594.

• J. Tao, K. Ramnarayanan, B. Huang, S.H. Leong, S.S. Lim, I.B. Tan, C.H. Ooi, J. Wu, M. Lee, S. Zhang, S.Y. Rha, H.C. Chung, O.L. Kon, V. Cacheux, C.T. Yap*, N. Palanisamy, P. Tan (2011). Genomic discovery of recurrent CD44-SLC1A2 gene fusions in gastric cancer. Science Translational Medicine. 2011 April 6, 3 (77): 77ra30.

• Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P. CD44-SLC1A2 gene fusions in gastric cancer. Sci Transl Med. 2011 Apr 6;3(77):77ra30.

• Y.C. Goh, C.T. Yap, B.H. Huang, A.D. Cronshaw, B.P. Leung, P.B.S. Lai, S.P. Hart, I. Dransfield, J.A. Ross (2011). Heat shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cellular and Molecular Life Sciences. 2011 May; 68(9):1581-92.

• P.N. Tay, P. Tan, Y. Lan, C.H. Leung, M. Laban, T.C. Tan, H. Ni, J. Manikandan, S.B. Rashid , B. Yan, C.T. Yap, L.H. Lim, Y.C. Lim, S.C. Hooi (2010). Palladin, an actin-associated protein, is required for adherens junction formation and intercellular adhesion in HCT116 colorectal cancer cells. International Journal of Oncology. 2010 Oct, 37: 909-926.

• B. Yan, C.T. Yap, S. Wang, C.K. Lee, F.M. Omar, M. Salto-Tellez, M.P. Kumarasinghe (2010). Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors. Acta histochemica. January, 112(1): 101-6.

• B. Yan, F.M. Omar, K. Das, W.H. Ng, C. Lim, K. Shiuan, C.T. Yap, M. Salto-Tellez (2008). Characterization of Numb expression in astrocytomas. Neuropathology. 2008, 28:479-484.

• C.T. Yap, T.I. Simpson, T. Pratt, D.J. Price, S.K. Maciver (2005). The motility of glioblastoma tumour cells is modulated by intracellular cofilin expression in a concentration-dependent manner. Cell Motility and the Cytoskeleton. 2005 Jan 20; 60(3):153-165.