{"id":5313,"date":"2017-05-04T10:53:52","date_gmt":"2017-05-04T02:53:52","guid":{"rendered":"http:\/\/https:\/\/medicine.nus.edu.sg\/pathweb\/?page_id=5313"},"modified":"2023-04-03T11:12:06","modified_gmt":"2023-04-03T03:12:06","slug":"cell-damage-and-death","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/","title":{"rendered":"Cell Damage and Death"},"content":{"rendered":"\n<h2>\n\t\tcell damage and death\n\t<\/h2>\n\t<h3><strong>Overview<\/strong><\/h3>\n<p>Cells respond to stress in several ways &#8211; they can <strong>adapt<\/strong> to a new steady state, they can become <strong>injured <\/strong>(reversibly or irreversibly), and they can <strong>die.<\/strong><\/p>\n<ul>\n<li>Sometimes, when some of the metabolic functions are deranged, they can also accumulate intracellular materials which are visible on the light microscopy.<\/li>\n<li>Causes of stress range from <strong>physiologic<\/strong> to<strong> pathologic<\/strong>. Physiologic or mild pathologic stimuli are more likely to result in adaptation, while more <strong>severe stress<\/strong> may lead to <strong>injury and cell death.<\/strong><\/li>\n<li>For cell injury and death, you will learn about:\n<ul>\n<li><strong>Definitions<\/strong> of specific important terms<\/li>\n<li><strong>Causes <\/strong>(eg. hypoxia, chemical agents etc.)<\/li>\n<li><strong>Mechanisms <\/strong>(i.e. ATP depletion, cell membrane damage etc)<\/li>\n<li><strong>Morphology<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3>\n\t\tMindmap: How cells respond to stress\n\t<\/h3>\n\t<p>The brief mindmap shows you how Cells respond to stress, whether physiologic or pathologic.<\/p>\n<p>If you can&#8217;t play the video, watch it here on YouTube: <a href=\"https:\/\/youtu.be\/lUMbZ-e5xew\" target=\"_blank\" rel=\"noopener\">https:\/\/youtu.be\/lUMbZ-e5xew<\/a><\/p>\n\t<iframe loading=\"lazy\" src=\"https:\/\/player.vimeo.com\/video\/211431553\" width=\"640\" height=\"479\" frameborder=\"0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe>\n\t<p>Click on each button to navigate the sections:<\/p>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/i-cell-adaptation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tI. Cell Adaptation\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/ii-cell-injury-and-death\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tII. Cell Injury and Death\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/iii-cell-damage-and-death-talking-pots-and-slides\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tIII. Cell Damage and Death: Talking Pots and Slides\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/cell-damage-and-death-exercises\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tIV. Cell Damage and Death: Exercises\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/cell-damage-and-death-quiz\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tV. Cell Damage and Death: Quiz\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/cell-damage-and-death-one-page-summary-study-notes\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tCell Damage and Death: Study Notes and One Page Summary\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tPathology Demystified\n\t\t\t\t\t<\/a>\n\n","protected":false},"excerpt":{"rendered":"<p>cell damage and death Overview Cells respond to stress in several ways &#8211; they can adapt to a new steady state, they can become injured (reversibly or irreversibly), and they can die. Sometimes, when some of the metabolic functions are deranged, they can also accumulate intracellular materials which are visible on the light microscopy. Causes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":825,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-5313","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NUS Pathweb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/cell-damage-and-death\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:description\" content=\"cell damage and death Overview Cells respond to stress in several ways &#8211; they can adapt to a new steady state, they can become injured (reversibly or irreversibly), and they can die. Sometimes, when some of the metabolic functions are deranged, they can also accumulate intracellular materials which are visible on the light microscopy. 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Sometimes, when some of the metabolic functions are deranged, they can also accumulate intracellular materials which are visible on the light microscopy. 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