{"id":4473,"date":"2017-03-30T16:15:06","date_gmt":"2017-03-30T08:15:06","guid":{"rendered":"http:\/\/https:\/\/medicine.nus.edu.sg\/pathweb\/?page_id=4473"},"modified":"2023-04-03T13:00:08","modified_gmt":"2023-04-03T05:00:08","slug":"what-is-inflammation","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-is-inflammation\/","title":{"rendered":"I. What is inflammation?"},"content":{"rendered":"\n\n\t<h3><strong>Definition of INFLAMMATION:<\/strong><\/h3>\n<p>Inflammation is a <strong>response of vascularised tissues<\/strong> to infection and damaged tissues that brings cells and molecules of host defence <strong>from the circulation<\/strong> <strong>to the sites<\/strong> where they are needed, in order to <strong>eliminate<\/strong> the offending agents.<\/p>\n<p><em>(Robbins and Cotran&#8217;s Pathologic Basis of Disease, 9<sup>th<\/sup> Edition, 2015)<\/em><\/p>\n\t<p><u>Let&#8217;s break this down:<\/u><\/p>\n<ul> \t\n<li><strong>Response of vascularised tissue<\/strong> &#8211; tissues need to be living (i.e. vascularised): vessels and blood components are key players<\/li>\n\n<li><strong>&#8230;to infection and damaged tissues&#8230; &#8211;<\/strong> some of the causes of inflammation<\/li>\n\n<li><strong>&#8230;from the circulation&#8230; <\/strong>&#8211; key events start from within the blood vessels (that&#8217;s where the cells and chemical mediators come from)<\/li>\n\n<li><strong>&#8230;to the sites&#8230;<\/strong> &#8211; cells travel to the site of injury &#8211; think about how they do that<\/li>\n\n<li><strong>&#8230;to eliminate&#8230;<\/strong> &#8211; this is the ultimate goal of inflammation: to get rid of the agent that is causing injury, as well as the dead tissue that accumulated during the event<\/li>\n<\/ul>\n<h3>\n\t\tBig picture mindmap\n\t<\/h3>\n\t<p>If you can&#8217;t play the video, watch it here on YouTube: <a href=\"https:\/\/youtu.be\/N9NhucExl9E\" target=\"_blank\" rel=\"noopener\">https:\/\/youtu.be\/N9NhucExl9E<\/a><\/p>\n\t<iframe loading=\"lazy\" src=\"https:\/\/player.vimeo.com\/video\/203765420\" width=\"640\" height=\"478\" frameborder=\"0\" webkitallowfullscreen mozallowfullscreen allowfullscreen><\/iframe>\n\t<p><strong>In summary:<\/strong><\/p>\n<ul> \t\n<li><strong>Inflammation is a protective mechanism<\/strong><\/li>\n\n<li><strong>It leads to healing of tissues<\/strong><\/li>\n<\/ul>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-is-inflammation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tI. What is Inflammation?\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-causes-inflammation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tII. What causes inflammation?\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-are-the-types-of-inflammation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tIII. What are the types of inflammation?\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-are-the-main-events-in-inflammation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tIV. What are the main events in inflammation?\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-brings-about-the-main-events-in-inflammation\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tV. What brings about the main events in inflammation?\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/talking-pots-and-slides\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tVI. Inflammation: Talking Pots and Slides\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/quiz\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tVII. Inflammation: Quizzes\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/inflammation-one-page-summary-study-notes\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tInflammation: Study Notes and One Page Summary\n\t\t\t\t\t<\/a>\n\t\t\t<a href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/\" target=\"_self\" role=\"button\" rel=\"noopener\">\n\t\t\t\t\t\t\tPathology Demystified\n\t\t\t\t\t<\/a>\n\n","protected":false},"excerpt":{"rendered":"<p>Definition of INFLAMMATION: Inflammation is a response of vascularised tissues to infection and damaged tissues that brings cells and molecules of host defence from the circulation to the sites where they are needed, in order to eliminate the offending agents. (Robbins and Cotran&#8217;s Pathologic Basis of Disease, 9th Edition, 2015) Let&#8217;s break this down: Response [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4465,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-4473","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NUS Pathweb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/pathweb\/pathology-demystified\/inflammation\/what-is-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:description\" content=\"Definition of INFLAMMATION: Inflammation is a response of vascularised tissues to infection and damaged tissues that brings cells and molecules of host defence from the circulation to the sites where they are needed, in order to eliminate the offending agents. 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