Lung case 1

Case writer: A/Prof Nga Min En

Clinical history:

  • 83M, history of multiple myeloma, diagnosed 5 years ago, with several relapses. Currently on chemotherapy for relapsed myeloma.
  • Presents with a persistently worsening cough, not improving with antibiotics. No significant weight loss.
  • CT scan of the lung shows peripheral consolidation and nodules in both lungs, with mass-like consolidation involving almost the entire right lower lobe. Some calcified pleural plaques are seen. No mediastinal or hilar lymphadenopathy is noted.
  • Transbronchial biopsy of the right lower lobe is performed.
  • What are the histologic findings?
  • What are your differential diagnoses?
  • What clinical information would be helpful in your diagnostic workup?
  • What ancillary tests would you do?

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