ACADEMIC STAFF

Prof Ng_0002_e_crop4

Contact Information

Email
patnsb@nus.edu.sg

Telephone
+65 6772 4709

Research Themes

  • HAEMATOLYMPHOID MALIGNANCY
  • EBV-ASSOCIATED T/NK LYMPHOPROLIFERATIVE DISEASE

Other Information

ORCID

orcid.org/0000-0001-6051-6410

Social Media

Ng Siok Bian

PROFESSOR, NUS
SENIOR CONSULTANT, NUH
RESEARCH DIRECTOR, NUHS
ASSOCIATE INVESTIGATOR, CANCER SCIENCE INSTITUTE, NUS
MEMBER, NUS CENTRE FOR CANCER RESEARCH (N2CR)

RESEARCH FOCUS

    • Characterizing the microenvironment and molecular mechanism driving oncogenesis in EBV-associated NK and T-Cell Lymphomas
    • Investigating the role of Epstein Barr virus in oncogenesis of EBV-associated T/NK lymphoproliferative diseases

BIOGRAPHY

Prof Ng Siok Bian received her medical degree from the National University of Singapore (NUS). She subsequently obtained Fellowship of the Royal College of Pathologists of Australasia and completed her specialty training in haematolymphoid pathology as a visiting fellow at the National Cancer Institute / National Institute of Health, Bethesda, USA. Prof Ng joined the Department of Pathology at NUS in 2007. She is currently the Research Director of the Department of Pathology and a council member of Clinician Scientist Academy at the National University Health System. Prof Ng also serves as a member of the International Lymphoma Study Group.

As a haematolymphoid pathologist, Prof Ng’s research focuses on EBV-associated T/NK-cell lymphomas. By employing integrative analytical methods—such as gene and miRNA expression profiling, spatial transcriptomics, and proteomics—she aims to uncover and validate key biomarkers and oncogenic pathways involved in these lymphomas. Her work also seeks to further dissect the complexity of the tumour microenvironment and to better understand the crosstalk between malignant and immune cells within this environment.

Recent Publications

    • Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma. Liu M, et al. Nat Commun. 2024 Mar 8;15(1):2113.

    • Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma. Hoppe MM, et al. Cancer Discov. 2023 May 4;13(5):1144-1163.

    • The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Alaggio R, et al. Leukemia. 2022 Jul;36(7):1720-1748.
    • Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS. Wai CMM, et al. Haematologica. 2022 Aug 1;107(8):1864-1879.
    • A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma. Tian XP, et al. Blood. 2021 Aug 12;138(6):452-463.
    • Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations. Lin GW, et al. Lancet Oncol. 2020 Feb;21(2):306-316.

Group Members

      • HU KAIJIE
      • SANDY KIM
      • DENG LICHANG
      • JUNE WONG XIN NI
      • THE PHYU
      • REAGAN ENTIGU
      • CHERYLETTE ANNE ALEXANDER
      • LEONG SAI MUN
Scroll to Top