ACADEMIC STAFF

CHEOK-Chit-Fang

Contact Information

Email
patcfc@nus.edu.sg

Telephone
+65 6772 7843

 

Research Themes

  • CANCER THERAPEUTICS
  • BREAST CANCER
  • COLORECTAL CANCER
  • HAEMATOLYMPHOID CANCER

 

Other Information

ORCID

orcid.org/0000-0001-8242-3995

Cheok Chit Fang​

ASSISTANT PROFESSOR, NUS
PRINCIPAL INVESTIGATOR, NUS
JOINT PRINCIPAL INVESTIGATOR, IMCB, A*STAR

RESEARCH FOCUS

    • Identifying molecular vulnerabilities in cancers, in DNA damage response networks and cellular metabolism
    • Developing novel therapeutics through in silico and SAR studies
    • Identifying molecular signatures predicting drug response through gene network analysis

BIOGRAPHY

Assistant Professor Cheok Chit Fang earned her B.Sc. (Hons) from Imperial College London and her DPhil from the University of Oxford. She began her research career at the University of Oxford (CRUK), focusing on genomic instability in cancers during her PhD training, followed by a Postdoctoral Fellowship at A*STAR, Singapore. Chit Fang's research centers on molecular vulnerabilities in cancers, laying the groundwork for identifying novel therapeutic targets and approaches. Through gene perturbation studies and chemical biology screens, her work uncovers new lead targets along with predictive biomarkers for diagnostics. Her research also extends into cancer metabolism, and the crosstalk with DNA damage and repair pathways.

COLLABORATIVE OPPORTUNITIES

Open to collaborative opportunities in:

i) DNA replication and damage responses in cells for therapeutic exploitation

ii) Manipulation of mitochondrial uncoupling in cells for neurodegenerative diseases and cancers

Technical expertise:

    • Single-molecule DNA fiber labeling for tracking of DNA replication ex vivo and in vivo
    • Study of Mitochondrial Superoxide/reactive oxygen species and cellular ROS status
    • Study of calcium fluxes in cells using live cell imaging and molecular inhibitors/activators
    • Monitoring of mitochondrial and cellular respiration

Recent Publications

  • p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis Elfar G, et al. Nucleic Acids Research (Accepted)
  • Mitochondrial uncoupling reveals a novel therapeutic target for p53-defective cancers. Kumar, et al. Nat Commun. 2018. Sep 26;9(1):3931.
  • Nitro-deficient niclosamide confers reduced​ genotoxicity and retains mitochondrial uncoupling activity for cancer therapy. Ngai TZ et al. In J Mol Sci. 2021. Sep 27;22(19):10420.
  • Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. Kong LR, et al. Nat Commun. 2020.  29;11(1):2086. 
  • Drugging in the absence of p53. AningOA, Cheok CF. J Mol Cell Biol. 2019. 1;11(3):255-264. 
  • Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability. Kumar R and Cheok CF. Sci Rep. 2017. 12;7(1):17367. 
  • p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication. Yeo CQX, et al. Cell Rep. 2016 Apr 5;15(1):132-146.

Group Members

        • GAMAL ELFAR
        • KENNETH LEE
        • FANG ZIYU
        • LU SIXIAO
        • FAITH HOW
        • CHUA BOON LIN
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