Our People

CHEOK-Chit-Fang

Contact Information

Email

patcfc@nus.edu.sg

Telephone

+65 6772 7843

 

Research Themes

  • CANCER THERAPEUTICS
  • BREAST CANCER
  • COLORECTAL CANCER
  • HAEMATOLYMPHOID CANCER

 

Other Information

ORCID

orcid.org/0000-0001-8242-3995

 

Cheok Chit Fang​

ASSISTANT PROFESSOR, NUS
PRINCIPAL INVESTIGATOR, NUS
JOINT PRINCIPAL INVESTIGATOR, IMCB, A*STAR

RESEARCH FOCUS

  • Identifying molecular vulnerabilities in cancers, in DNA damage response networks and cellular metabolism
  • Developing novel therapeutics through in silico and SAR studies
  • Identifying molecular signatures predicting drug response through gene network analysis

BIOGRAPHY

Asst Prof Cheok Chit Fang received her B.Sc (Hons) from Imperial College London and her DPhil degree from the University of Oxford. Chit Fang started her career in PhD training in genomic instability in cancers with Prof Ian Hickson at the University of Oxford (CRUK) before completing a Postdoctoral Fellowship with Sir David Lane at A*STAR (Singapore). Her interest in molecular vulnerabilities in cancers forms the fundamental basis of her research in identifying new therapeutic targets and modalities. By exploiting gene perturbation studies and chemical biology screens, new lead targets are identified with accompanying biomarkers as predictive diagnostics. This work has also broadened to encompass interests in cancer metabolism as well as DNA damage and repair pathways. Her interest in genomic stability has also led her to explore the molecular basis of aging.

COLLABORATIVE OPPORTUNITIES

Open to collaborative opportunities in:

i)DNA replication and damage responses in cells for therapeutic exploitation

ii)manipulation of mitochondrial uncoupling in cells for neurodegenerative diseases and cancers

Technical expertise:

  • Single-molecule DNA fiber labeling for tracking of DNA replication ex vivo and in vivo
  • Study of Mitochondrial Superoxide/reactive oxygen species and cellular ROS status
  • Study of calcium fluxes in cells using live cell imaging and molecular inhibitors/activators
  • Monitoring of mitochondrial and cellular respiration

Group Members

  • KENNETH LEE
  • GAMAL ELFAR
  • MANSI MISHRA
  • GUAN WEI
Cheok Chit Fang-right

Recent Publications

Mitochondrial uncoupling reveals a novel therapeutic target for p53-defective cancers. Kumar, et al. Nat Commun. 2018. Sep 26;9(1):3931.

Nitro-deficient niclosamide confers reduced​ genotoxicity and retains mitochondrial uncoupling activity for cancer therapy. HNgai TZ et al. In J Mol Sci. 2021. Sep 27;22(19):10420.

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation. Le TBU, et al. Nat Commun. 2020.  29;11(1):2086. 

Drugging in the absence of p53. Aning OA, Cheok CF. J Mol Cell Biol. 2019. 1;11(3):255-264. 

Dynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability. Kumar R, Cheok CF. Sci Rep. 2017. 12;7(1):17367. 

Exploiting the p53 Pathway for Therapy. Cheok CF, Lane DP. Cold Spring Harb Perspect Med. 2017.7(3):a026310.

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication. Yeo CQX, et al. Cell Rep. 2016 Apr 5;15(1):132-146.

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