Our People

Prof Ng_0002_e_crop4

Contact Information

Email

patnsb@nus.edu.sg

Telephone

+65 6772 4709

Research Themes

  • HAEMATOLYMPHOID MALIGNANCY
  • EBV-ASSOCIATED T/NK LYMPHOPROLIFERATIVE DISEASE

Other Information

ORCID

orcid.org/0000-0001-6051-6410

Social Media

Ng Siok Bian

ASSOCIATE PROFESSOR, NUS
SENIOR CONSULTANT, NUH
RESEARCH DIRECTOR, NUHS
ASSOCIATE PROFESSOR, CANCER SCIENCE INSTITUTE, NUS
Member, NUS CENTRE FOR CANCER RESEARCH (N2CR)

RESEARCH FOCUS

  • Characterizing the microenvironment and molecular mechanism driving oncogenesis in Natural Killer T-Cell Lymphoma (NKTL)
  • Investigating the role of Epstein Barr virus in lymphogenesis of EBV-associated T/NK lymphoproliferative disease

BIOGRAPHY

A/Prof Ng Siok Bian obtained her medical degrees from the National University of Singapore and obtained the Fellowship of the Royal College of Pathologists of Australasia. She subsequently completed her specialty training in haematolymphoid pathology as a visiting fellow at National Cancer Institute / National Institute of Health, Bethesda, USA, under the supervision of Dr ES Jaffe. A/Prof Ng joined the department of Pathology, NUS in 2007. She is currently the research director of the department of Pathology in National University Health System (NUHS).

A/Prof Ng’s diagnostic expertise is in haematolymphoid pathology and molecular pathology. Her research focus is on lymphomas, in particular EBV-associated T/NK-cell lymphomas, using a combinational analytical approach via gene and miRNA expression profiling on paraffin embedded tissue samples. Her group also has expertise in quantitative immunofluorescence using multispectral imaging platform.

Group Members

  • LEONG SAI MUN
  • REAGAN ENTIGU
  • CHERYLETTE ANNE ALEXANDER
  • FAN SHUANGYI
  • THE PHYU
  • DOROTHY LIM
  • JUNE WONG XIN NI
Ng Siok Bian-right

Recent Publications

Cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases: emerging concepts, recent advances, and the putative role of clonal hematopoiesis. A report of the 2022 EA4HP/SH lymphoma workshop. Climent F, et al. Virchows Arch. 2023 Sep;483(3):333-348. 

Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma. Hoppe MM, et al. Cancer Discov. 2023 May 4;13(5):1144-1163. 

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Alaggio R, et al. Leukemia. 2022 Jul;36(7):1720-1748.

Immune pathway upregulation and lower genomic instability distinguish EBV-positive nodal T/NK-cell lymphoma from ENKTL and PTCL-NOS. Wai CMM, et al. Haematologica. 2022 Aug 1;107(8):1864-1879.

A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma. Tian XP, et al. Blood. 2021 Aug 12;138(6):452-463.

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations. Lin GW, et al. Lancet Oncol. 2020 Feb;21(2):306-316.

 

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