{"id":4560,"date":"2020-11-03T18:20:08","date_gmt":"2020-11-03T10:20:08","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/nuhscg\/?p=4560"},"modified":"2023-10-18T13:55:56","modified_gmt":"2023-10-18T05:55:56","slug":"an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/","title":{"rendered":"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing)"},"content":{"rendered":"<p>To participate, visit <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03038035?term=MLC901-2&amp;rank=1\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>ClinicalTrials.gov<\/strong><\/a> for registration!<\/p>\r\n<p style=\"text-align: justify\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-160 size-medium\" src=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg\" alt=\"\" width=\"211\" height=\"300\" \/><\/p>\r\n<p><img decoding=\"async\" class=\"alignnone wp-image-161 size-medium\" src=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example2-300x209-1.jpg\" alt=\"\" width=\"300\" height=\"209\" \/><\/p>\r\n<p style=\"text-align: justify\">Sponsor: National University Hospital<\/p>\r\n<h4 style=\"text-align: justify\">Research Aims<\/h4>\r\n<p style=\"text-align: justify\">The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.<\/p>\r\n<h4 style=\"text-align: justify\">How the Core Is Integral to the Study<\/h4>\r\n<ul style=\"text-align: justify\">\r\n\t<li>Coordinated site start-up<\/li>\r\n\t<li>Recruited and retained subjects (&gt;100 patients recruited, with a retention rate of 98%)<\/li>\r\n\t<li>Obtained regulatory and safety approvals: included obtaining the necessary regulatory approvals from the Health Sciences Authority (HSA), such as the clinical trial certificate, as well as ethics and safety committee (DSRB) approvals<\/li>\r\n\t<li>Performed the following cognitive assessments to help determine efficacy of NeuroAid for cognitive function:\r\n\r\n<ul>\r\n\t<li>Alzheimer&#8217;s Disease Assessment Scale &#8211; Cognitive (ADAS-COG)<\/li>\r\n\t<li>Mini Mental State Examination (MMSE)<\/li>\r\n<\/ul>\r\n<\/li>\r\n\t<li>Performed the following assessments to help determine efficacy of NeuroAid for slowing AD disease progression:\r\n\r\n<ul>\r\n\t<li>Alzheimer\u2019s Disease Cooperative Study &#8211; Clinical Global Impression of Change (ADCS-CGIC)<\/li>\r\n\t<li>Neuropsychiatric Inventory (NPI)<\/li>\r\n\t<li>Alzheimer&#8217;s Disease Co-operative Study &#8211; Activities of Daily Living (ADCS-ADL)<\/li>\r\n\t<li>ADAS-COG<\/li>\r\n\t<li>MMSE<\/li>\r\n<\/ul>\r\n<\/li>\r\n\t<li>Trained raters for the above assessments<\/li>\r\n\t<li>Data management, including development of study database and data monitoring (filling in missing data; editing incorrect data)<\/li>\r\n<\/ul>\r\n<h4 style=\"text-align: justify\">Results<\/h4>\r\n<p>Since this trial is still ongoing, outcomes have not been reported yet. Watch this space for updates!<\/p>\r\n<h4>Find out more!<\/h4>\r\n<p>Visit our <a href=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/core-facilities\/neurocognitive-core\/menu-of-services\/\" target=\"_blank\" rel=\"noopener noreferrer\">Menu of Services<\/a> page to find out more about our services and prices.<\/p>","protected":false},"excerpt":{"rendered":"To participate, visit ClinicalTrials.gov for registration! Sponsor: National University Hospital Research Aims The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of&#8230;","protected":false},"author":4,"featured_media":2584,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[50,26,1],"tags":[],"class_list":["post-4560","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-example-projects-neurocognitive-core","category-neurocognitive-core","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience<\/title>\n<meta name=\"description\" content=\"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience\" \/>\n<meta property=\"og:description\" content=\"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/\" \/>\n<meta property=\"og:site_name\" content=\"NUHS Centre Grant\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-03T10:20:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-18T05:55:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"211\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/\",\"name\":\"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg\",\"datePublished\":\"2020-11-03T10:20:08+00:00\",\"dateModified\":\"2023-10-18T05:55:56+00:00\",\"author\":{\"@id\":\"\"},\"description\":\"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.\",\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage\",\"url\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg\",\"contentUrl\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg\",\"width\":211,\"height\":300},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/\",\"name\":\"NUHS Centre Grant\",\"description\":\"Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"\",\"url\":\"https:\/\/medicine.nus.edu.sg\/nuhscg\/author\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience","description":"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/","og_locale":"en_US","og_type":"article","og_title":"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience","og_description":"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.","og_url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/","og_site_name":"NUHS Centre Grant","article_published_time":"2020-11-03T10:20:08+00:00","article_modified_time":"2023-10-18T05:55:56+00:00","og_image":[{"width":211,"height":300,"url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Written by":"","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/","url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/","name":"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing) | Example Projects, Neurocognitive Core, News | NUHS Centre Grant - Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/#website"},"primaryImageOfPage":{"@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage"},"image":{"@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage"},"thumbnailUrl":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg","datePublished":"2020-11-03T10:20:08+00:00","dateModified":"2023-10-18T05:55:56+00:00","author":{"@id":""},"description":"The aims of this study are to determine the safety and efficacy of Neuroaid II (MLC901), in combination with standard treatment (cholinesterase inhibitors or memantine), in patients with mild to moderate Alzheimer\u2019s disease. NeuroAid is a mixture of nine herbal substances used in traditional Chinese medicine. To determine the efficacy of NeuroAid, the investigators are evaluating its effect on cognitive function and disease progression in these patients.","breadcrumb":{"@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#primaryimage","url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg","contentUrl":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-content\/uploads\/sites\/6\/2019\/12\/example1-211x300-1.jpg","width":211,"height":300},{"@type":"BreadcrumbList","@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/an-investigator-initiated-randomized-double-blind-placebo-controlled-trial-ongoing\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medicine.nus.edu.sg\/nuhscg\/"},{"@type":"ListItem","position":2,"name":"An investigator-initiated randomized, double-blind, placebo-controlled trial (ongoing)"}]},{"@type":"WebSite","@id":"https:\/\/medicine.nus.edu.sg\/nuhscg\/#website","url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/","name":"NUHS Centre Grant","description":"Singapore Core Facilities for Diabetes, Infectious Diseases and Neuroscience","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicine.nus.edu.sg\/nuhscg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"","url":"https:\/\/medicine.nus.edu.sg\/nuhscg\/author\/"}]}},"_links":{"self":[{"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/posts\/4560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/comments?post=4560"}],"version-history":[{"count":4,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/posts\/4560\/revisions"}],"predecessor-version":[{"id":4568,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/posts\/4560\/revisions\/4568"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/media\/2584"}],"wp:attachment":[{"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/media?parent=4560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/categories?post=4560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/nuhscg\/wp-json\/wp\/v2\/tags?post=4560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}