{"id":680,"date":"2022-04-24T07:11:38","date_gmt":"2022-04-24T07:11:38","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=680"},"modified":"2022-11-28T07:11:57","modified_gmt":"2022-11-28T07:11:57","slug":"nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/news\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\/","title":{"rendered":"NUS scientists discover promising biologic drug for treating chronic lung disease"},"content":{"rendered":"<p>NUS scientists have discovered a novel property of a protein found in human lungs which could lead to the development of biologic drugs to treat chronic obstructive pulmonary disease (COPD), a debilitating, progressive lung disease that is one of the leading causes of death worldwide.<\/p>\n<p>The research was led by Associate Professor Ge Ruowen (left) from NUS Biological Sciences and published in the prestigious scientific journal Proceedings of the National Academy of Sciences (PNAS) in January 2022.<\/p>\n<p>The research team worked with Professor Fred Wong (right) at NUS Pharmacology, to conduct laboratory studies to examine the effectiveness of delivering recombinant ISM1 protein directly via droplets into the airway. The researchers observed a reduction in lung inflammation, suppression of emphysema development, and restoration of lung functions. These findings lend support to the development of ISM1 as a potential treatment for COPD.<\/p>\n<ul>\n<li><a href=\"https:\/\/news.nus.edu.sg\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease\/\" target=\"_blank\" rel=\"noopener\">More News Details<\/a><\/li>\n<li><a href=\"https:\/\/www.straitstimes.com\/singapore\/health\/nus-scientists-find-that-certain-protein-can-suppress-inflammation-that-comes-with-chronic-lung-disease\" target=\"_blank\" rel=\"noopener\">The Straits Times News<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>NUS scientists have discovered a novel property of a protein found in human lungs which could lead to the development of biologic drugs to treat chronic obstructive pulmonary disease (COPD), a debilitating, progressive lung disease that is one of the leading causes of death worldwide. The research was led by Associate Professor Ge Ruowen (left) [&hellip;]<\/p>\n","protected":false},"author":8988,"featured_media":653,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[4],"tags":[],"class_list":["post-680","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NUS scientists discover promising biologic drug for treating chronic lung disease - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/news\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NUS scientists discover promising biologic drug for treating chronic lung disease - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"NUS scientists have discovered a novel property of a protein found in human lungs which could lead to the development of biologic drugs to treat chronic obstructive pulmonary disease (COPD), a debilitating, progressive lung disease that is one of the leading causes of death worldwide. The research was led by Associate Professor Ge Ruowen (left) [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/news\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-24T07:11:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-28T07:11:57+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2022\/11\/FW-and-GR.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1800\" \/>\n\t<meta property=\"og:image:height\" content=\"1200\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"websparksadmin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"websparksadmin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/\"},\"author\":{\"name\":\"websparksadmin\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#\\\/schema\\\/person\\\/63d32bd3a46e7e12626429a0d5da93ec\"},\"headline\":\"NUS scientists discover promising biologic drug for treating chronic lung disease\",\"datePublished\":\"2022-04-24T07:11:38+00:00\",\"dateModified\":\"2022-11-28T07:11:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/\"},\"wordCount\":157,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/wp-content\\\/uploads\\\/sites\\\/33\\\/2022\\\/11\\\/FW-and-GR.jpg\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/news\\\/nus-scientists-discover-promising-biologic-drug-for-treating-chronic-lung-disease-2\\\/\",\"name\":\"NUS scientists discover promising biologic drug for treating chronic lung disease - 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