{"id":3527,"date":"2026-08-21T02:11:37","date_gmt":"2026-08-21T02:11:37","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=3527"},"modified":"2026-08-21T02:11:37","modified_gmt":"2026-08-21T02:11:37","slug":"preparing-for-change-how-systems-thinking-supports-an-effective-transition-from-animal-studies-to-nams","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/preparing-for-change-how-systems-thinking-supports-an-effective-transition-from-animal-studies-to-nams\/","title":{"rendered":"Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs"},"content":{"rendered":"

\"\"<\/p>\n

Overview of principal CHANGE publications.<\/span><\/p>\n

\n\n\n\n
CHANGE publications<\/th>\nSummary<\/th>\n<\/tr>\n<\/thead>\n<\/table>\n<\/div>\n\n\n\n\n\n\n\n\n\n\n\n
Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology (Mathisen et al., 2024<\/span><\/span><\/a>)<\/td>\nCommentary introducing the CHANGE project, its rationale, objectives, and three-phase \u201cexplore, reflect, design\u201d methodological approach.<\/td>\n<\/tr>\n
Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies (Bearth et al., 2025<\/span><\/span><\/a>)<\/td>\nResearch article describing the \u201cexplore\u201d phase of CHANGE, eliciting from people working in or around the regulatory toxicology system their experience of barriers and enablers of use of NAM data.<\/td>\n<\/tr>\n
Improving how we use workshops when solving complex research problems: reflections from the CHANGE project (Jones et al., 2025<\/span><\/span><\/a>)<\/td>\nMethods article presenting recommendations for conduct of participatory research workshops, emphasising project team structures, effective social interaction, and facilitation strategies.<\/td>\n<\/tr>\n
How to organise a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18\u201320 June 2024 (Diemar et al., 2025<\/span><\/span><\/a>)<\/td>\nCommentary and companion piece to Jones et al. (2025)<\/span><\/span><\/a>, presenting participant perspectives on the first in-person CHANGE workshop, reflecting on the strengths and challenges of the approaches used.<\/td>\n<\/tr>\n
Modelling the Regulatory Toxicology System to Promote the Effective Use of New Approach Methodologies: A System Thinking Approach (Bearth et al., submitted<\/span><\/span><\/a>)<\/td>\nResearch article describing the \u201creflect\u201d phase of CHANGE, presenting the CHANGE system model and the methods used to derive the model from participants\u2019 experience of working in or around the regulatory toxicology system.<\/td>\n<\/tr>\n
Report of Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) 2nd workshop in Oslo, June 24 – 26, 2025 \u2013 participants perspectives on the CHANGE working methodology (Diemar et al., submitted<\/span><\/span><\/a>)<\/td>\nProvides participants’ reflections on the second (“reflect”) in-person workshop, including the collaborative approach used to refine system understanding, and the value of the workshop for identifying ways to support the uptake of NAMs.<\/td>\n<\/tr>\n
A protocol for organising co-design research workshops (title to be decided, in preparation<\/em>)<\/td>\nA repeatable, step-by-step procedure to support the planning, design and delivery of successful co-creation or co-design workshops.<\/td>\n<\/tr>\n
CHANGE white paper (title to be decided, in preparation<\/em>)<\/td>\nThe main intended deliverable of CHANGE, a policy white paper for decision-makers working in or around regulatory toxicology, presenting a series of system-level interventions that can be expected to improve the effectiveness of use of NAMs in regulatory toxicology.<\/td>\n<\/tr>\n
Designing system-level interventions for improving the effectiveness of use of NAMs in regulatory toxicology (title to be decided, forthcoming<\/em>)<\/td>\nFinal research article describing the methods and results of the \u201cdesign\u201d phase of CHANGE, as the detailed work underpinning the White Paper.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Full Article:\u00a0https:\/\/www.sciencedirect.com\/science\/article\/pii\/S3050620426000436?via%3Dihub#tbl0001<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Overview of principal CHANGE publications. CHANGE publications Summary Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology (Mathisen et al., 2024) Commentary introducing the CHANGE project, its rationale, objectives, and three-phase \u201cexplore, reflect, design\u201d methodological approach. Exploring experiences of the regulatory toxicology system: system-level promoters and […]<\/p>\n","protected":false},"author":9345,"featured_media":3528,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"\nPreparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/preparing-for-change-how-systems-thinking-supports-an-effective-transition-from-animal-studies-to-nams\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Overview of principal CHANGE publications. 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