{"id":3398,"date":"2026-06-17T07:57:30","date_gmt":"2026-06-17T07:57:30","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=3398"},"modified":"2026-06-17T07:57:30","modified_gmt":"2026-06-17T07:57:30","slug":"evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\/","title":{"rendered":"Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-3399\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH-300x169.jpg\" alt=\"\" width=\"850\" height=\"479\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH-768x432.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH.jpg 1280w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/p>\n<h2 id=\"d68771485\" class=\"article-section__header section__title main abstractlang_en main\">Abstract<\/h2>\n<div class=\"article-section__content en main\">\n<section id=\"alz71264-sec-0010\" class=\"article-section__content\">\n<h3 id=\"alz71264-sec-0010-title\" class=\"article-section__sub-title section1\"><span style=\"font-size: 14pt;\">INTRODUCTION<\/span><\/h3>\n<p>Cortical cerebral microinfarcts (CMIs) are associated with cognitive dysfunction and dementia, while their evolution on sequential magnetic resonance imaging (MRI) remains unclear.<\/p>\n<\/section>\n<section id=\"alz71264-sec-0020\" class=\"article-section__content\">\n<h3 id=\"alz71264-sec-0020-title\" class=\"article-section__sub-title section1\"><span style=\"font-size: 14pt;\">METHODS<\/span><\/h3>\n<p>The study enrolled 490 patients (72.5\u00a0\u00b1\u00a07.9 years) from a memory-clinic cohort, with 5-year follow-up. Cortical CMIs were graded at baseline and year 2 to identify incident lesions and other evolutionary patterns. Cognitive function was assessed annually. Clinical events, including dementia, stroke, and mortality, were recorded with time to event.<\/p>\n<\/section>\n<section id=\"alz71264-sec-0030\" class=\"article-section__content\">\n<h3 id=\"alz71264-sec-0030-title\" class=\"article-section__sub-title section1\"><span style=\"font-size: 14pt;\">RESULTS<\/span><\/h3>\n<p>Forty-one (8.4%) patients showed incident cortical CMIs at year 2. Additionally, 12 had CMIs becoming invisible, and six showed CMIs incorporated into new large infarctions. Baseline cortical CMIs and large cortical infarcts showed the strongest association with incident CMIs. Incident cortical CMIs were associated with cognitive decline, white matter hyperintensity progression, and incident dementia, independent of prevalent lesions.<\/p>\n<\/section>\n<section id=\"alz71264-sec-0040\" class=\"article-section__content\">\n<h3 id=\"alz71264-sec-0040-title\" class=\"article-section__sub-title section1\"><span style=\"font-size: 14pt;\">DISCUSSION<\/span><\/h3>\n<p>Cortical CMI evolution may reflect dynamic changes in brain vascular pathology and represent a potential target for interventions aimed at preserving cognitive function.<\/p>\n<\/section>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Abstract INTRODUCTION Cortical cerebral microinfarcts (CMIs) are associated with cognitive dysfunction and dementia, while their evolution on sequential magnetic resonance imaging (MRI) remains unclear. METHODS The study enrolled 490 patients (72.5\u00a0\u00b1\u00a07.9 years) from a memory-clinic cohort, with 5-year follow-up. Cortical CMIs were graded at baseline and year 2 to identify incident lesions and other evolutionary [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":3399,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Abstract INTRODUCTION Cortical cerebral microinfarcts (CMIs) are associated with cognitive dysfunction and dementia, while their evolution on sequential magnetic resonance imaging (MRI) remains unclear. METHODS The study enrolled 490 patients (72.5\u00a0\u00b1\u00a07.9 years) from a memory-clinic cohort, with 5-year follow-up. Cortical CMIs were graded at baseline and year 2 to identify incident lesions and other evolutionary [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-17T07:57:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2026\/06\/20260316-SH.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Woon Fei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Woon Fei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/\"},\"author\":{\"name\":\"Woon Fei\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#\\\/schema\\\/person\\\/ea3ccd10ab2f2bba51fd804396287cb0\"},\"headline\":\"Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance\",\"datePublished\":\"2026-06-17T07:57:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/\"},\"wordCount\":164,\"publisher\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/wp-content\\\/uploads\\\/sites\\\/33\\\/2026\\\/06\\\/20260316-SH.jpg\",\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/evolution-of-cortical-cerebral-microinfarcts-on-3t-mri-risk-factors-and-clinical-relevance\\\/\",\"name\":\"Evolution of cortical cerebral microinfarcts on 3T MRI: risk factors and clinical relevance - 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