{"id":3072,"date":"2025-08-12T02:26:43","date_gmt":"2025-08-12T02:26:43","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=3072"},"modified":"2025-08-12T02:29:45","modified_gmt":"2025-08-12T02:29:45","slug":"tgf-%ce%b2-driven-emt-in-cancer-progression-and-drug-resistance","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/tgf-%ce%b2-driven-emt-in-cancer-progression-and-drug-resistance\/","title":{"rendered":"TGF-\u03b2-driven EMT in cancer progression and drug resistance"},"content":{"rendered":"\n\n\n
\"\"<\/td>\n\"\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Abstract<\/h2>\n

The carcinogenesis and drug resistance can be accelerated by TGF-\u03b2, primarily by enhancing epithelial-mesenchymal transition (EMT). This review examines the complex mechanisms by which TGF-\u03b2 drives EMT across different tumors, highlighting its function in increasing cellular plasticity, promoting metastasis, and contributing to therapy resistance. TGF-\u03b2 activates both canonical Smad-dependent and non-canonical signaling, leading to profound changes in cell morphology, motility, and stemness. This review highlights recent discoveries on how TGF-\u03b2 regulates cancer stem cells and contributes to drug resistance, including resistance to both conventional chemotherapy and targeted treatments. In addition, it examines the intricate interaction between TGF-\u03b2 and the key molecular pathways controlling EMT, such as PI3K\/AKT, MAPK, and epigenetic regulators. It also examines potential therapeutic approaches aimed at TGF-\u03b2-induced EMT, emphasizing promising preclinical results from novel compounds and combination therapies\u2014including natural products, small-molecule inhibitors, and epigenetic regulators\u2014that interfere with TGF-\u03b2 receptor activation or downstream signaling pathways. Understanding these complex interactions provides valuable insights for developing more effective cancer therapies. The review concludes by identifying key research gaps as well as suggesting future directions for investigating TGF-\u03b2’s role in cancer biology and treatment resistance.<\/p>\n

Full Article:\u00a0https:\/\/doi.org\/10.1016\/j.cytogfr.2025.05.004<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Abstract The carcinogenesis and drug resistance can be accelerated by TGF-\u03b2, primarily by enhancing epithelial-mesenchymal transition (EMT). This review examines the complex mechanisms by which TGF-\u03b2 drives EMT across different tumors, highlighting its function in increasing cellular plasticity, promoting metastasis, and contributing to therapy resistance. TGF-\u03b2 activates both canonical Smad-dependent and non-canonical signaling, leading to […]<\/p>\n","protected":false},"author":9345,"featured_media":3073,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3072","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"\nTGF-\u03b2-driven EMT in cancer progression and drug resistance - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/tgf-\u03b2-driven-emt-in-cancer-progression-and-drug-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TGF-\u03b2-driven EMT in cancer progression and drug resistance - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Abstract The carcinogenesis and drug resistance can be accelerated by TGF-\u03b2, primarily by enhancing epithelial-mesenchymal transition (EMT). 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