{"id":3032,"date":"2025-07-23T06:17:51","date_gmt":"2025-07-23T06:17:51","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=3032"},"modified":"2025-07-23T06:17:51","modified_gmt":"2025-07-23T06:17:51","slug":"from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/","title":{"rendered":"From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-3033\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK-300x169.jpg\" alt=\"\" width=\"950\" height=\"535\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK-768x432.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK.jpg 1280w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/p>\n<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<p>The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin, a bioactive component derived from the rhizome of the turmeric plant (<i>Curcuma longa<\/i> L.), has been primarily used in culinary applications for several centuries, but now its potential health benefits are the focus of growing scientific research. Interestingly, some studies have found that curcumin has antitumorigenic effects due to its ability to influence the tumor microenvironment and possibly promote immune system response by modulating specific signaling pathways in immune cells. The interaction of curcumin with immune cells in the field of cancer chemoprevention is a complex area of research. It has been suggested that curcumin might promote T cell recruitment, reduce neutrophil and macrophage accumulation in the tumor microenvironment, and prevent the conversion of infiltrating lymphocytes into immunosuppressive subpopulations. Thus, its possible mechanisms of action also include a shift of the immune balance toward activation by reversing the prevalence of immunosuppressive cells. With innovations and improvements in our understanding of the potential benefits of curcumin on immune cells in cancer prevention and treatment, it is important to have an overview of current findings. Therefore, in this study, we aim to provide a review of the latest discoveries regarding curcumin in the field of cancer and immune cell research.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin, a bioactive component derived from the rhizome of the turmeric plant (Curcuma longa L.), has been primarily used in culinary applications for several centuries, but now its potential health benefits are the focus of growing [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":3033,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Abstract The use of natural compounds as effective therapeutic agents is an expanding area of health and disease research. Curcumin, a bioactive component derived from the rhizome of the turmeric plant (Curcuma longa L.), has been primarily used in culinary applications for several centuries, but now its potential health benefits are the focus of growing [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-23T06:17:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Woon Fei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Woon Fei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\"},\"author\":{\"name\":\"Woon Fei\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/ea3ccd10ab2f2bba51fd804396287cb0\"},\"headline\":\"From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management\",\"datePublished\":\"2025-07-23T06:17:51+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\"},\"wordCount\":232,\"publisher\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#organization\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/07\/20250723-0417-APK.jpg\",\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/from-bench-to-bedside-exploring-curcumin-driven-signaling-pathways-in-immune-cells-for-cancer-management\/\",\"name\":\"From bench to bedside: exploring curcumin-driven signaling pathways in immune cells for cancer management - 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