{"id":2964,"date":"2025-06-16T03:01:17","date_gmt":"2025-06-16T03:01:17","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=2964"},"modified":"2025-06-20T03:06:21","modified_gmt":"2025-06-20T03:06:21","slug":"plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/","title":{"rendered":"Plasma proteomics for cognitive decline and dementia &#8211; A Southeast Asian cohort study"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2965 size-full\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16.jpg\" alt=\"\" width=\"1280\" height=\"720\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16.jpg 1280w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16-768x432.jpg 768w\" sizes=\"auto, (max-width: 1280px) 100vw, 1280px\" \/><\/p>\n<p><span style=\"font-size: 18pt;\"><strong>Abstract<\/strong><\/span><\/p>\n<p><strong class=\"sub-title\">Introduction:\u00a0<\/strong>The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>We examined this in a Singaporean memory clinic cohort of 528 subjects (n = 300, CeVD; n = 167, incident cognitive decline) followed-up for 4 years.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Of 1441 plasma proteins surveyed, a 12-protein signature significantly predicted cognitive decline (q-value &lt; .05). Sixteen diverse biological processes were implicated in cognitive decline. Ten proteins independently predicted incident dementia (q-value &lt; .05). A unified prediction model combining plasma proteins with clinical risk factors increased the area under the curve for outcome prediction from 0.62 to 0.85. External validation in the cerebrospinal fluid proteome of an independent Caucasian cohort replicated four of the significantly predictive plasma markers for cognitive decline namely: GFAP, NEFL, AREG, and PPY.<\/p>\n<p><strong class=\"sub-title\">Discussion:\u00a0<\/strong>The prognostic proteins prioritized in our study provide robust signals in two different biological matrices, representing potential mechanistic targets for dementia and cognitive decline.<\/p>\n<p><strong class=\"sub-title\">Highlights:\u00a0<\/strong>A total of 1441 plasma proteins were profiled in a Singaporean memory clinic cohort. We report prognostic plasma protein signatures for cognitive decline and dementia. External validation was performed in the cerebrospinal fluid proteome of a Caucasian cohort. A concordant proteomic signature was identified across both biofluids and cohorts. Further studies are needed to explore the therapeutic implications of these proteins for dementia.<\/p>\n<p>Full article: <a href=\"https:\/\/doi.org\/10.1002\/alz.14577\">https:\/\/doi.org\/10.1002\/alz.14577<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Introduction:\u00a0The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored. Methods:\u00a0We examined this in a Singaporean memory clinic cohort of 528 subjects (n = 300, CeVD; n = 167, incident cognitive decline) followed-up for 4 years. Results:\u00a0Of 1441 plasma [&hellip;]<\/p>\n","protected":false},"author":9339,"featured_media":2965,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2964","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Plasma proteomics for cognitive decline and dementia - A Southeast Asian cohort study - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plasma proteomics for cognitive decline and dementia - A Southeast Asian cohort study - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Abstract Introduction:\u00a0The prognostic utility of plasma proteomics for cognitive decline and dementia in a Southeast Asian population characterized by high cerebrovascular disease (CeVD) burden is underexplored. Methods:\u00a0We examined this in a Singaporean memory clinic cohort of 528 subjects (n = 300, CeVD; n = 167, incident cognitive decline) followed-up for 4 years. Results:\u00a0Of 1441 plasma [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-16T03:01:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-20T03:06:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Alan KOH\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alan KOH\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\"},\"author\":{\"name\":\"Alan KOH\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/7d3c6eda1bb38ccc10654332cc8ddd5e\"},\"headline\":\"Plasma proteomics for cognitive decline and dementia &#8211; A Southeast Asian cohort study\",\"datePublished\":\"2025-06-16T03:01:17+00:00\",\"dateModified\":\"2025-06-20T03:06:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\"},\"wordCount\":237,\"publisher\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#organization\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/CC-Publication-2025-06-16.jpg\",\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/plasma-proteomics-for-cognitive-decline-and-dementia-a-southeast-asian-cohort-study\/\",\"name\":\"Plasma proteomics for cognitive decline and dementia - 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