{"id":2921,"date":"2025-06-03T03:15:05","date_gmt":"2025-06-03T03:15:05","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=2921"},"modified":"2025-06-06T02:07:13","modified_gmt":"2025-06-06T02:07:13","slug":"gut-microbiota-and-their-influence-in-brain-cancer-milieu","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/","title":{"rendered":"Gut microbiota and their influence in brain cancer milieu"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-2922\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS-300x169.jpg\" alt=\"\" width=\"950\" height=\"535\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS-768x432.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg 1280w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/p>\n<p><strong><span style=\"font-size: 14pt;\">Abstract<\/span><\/strong><br \/>\nMicrobial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the various regions of the human body has numerous roles in different physiological processes such as nutrition, metabolism, immune regulation, etc. In the zeal of achieving empirical insights into the ambit of the gut microbiome, the research over the years led to the revelation of reciprocal interaction between the gut<br \/>\nmicrobiome and the cognitive functioning of the human body. Dysbiosis in the gut microbial composition disturbs the homeostatic cognitive functioning of the human body. This dysbiosis has been associated with various chronic diseases, including brain cancer, such as glioma, glioblastoma, etc. This review explores the mechanistic role of dysbiosis-mediated progression of brain cancers and their subtypes. Moreover, it demonstrates the regulatory role of microbial metabolites produced by the gut microbiota, such as short-chain fatty acids, amino acids, lipids, etc., in the tumour progression. Further, we also provide valuable insights into the microbiota mediating the efficiency of therapeutic regimens, thereby leveraging gut microbiota as potential biomarkers and targets for improved treatment outcomes.<\/p>\n<p>Full article:\u00a0<a href=\"https:\/\/doi.org\/10.1186\/s12974-025-03434-2\">https:\/\/doi.org\/10.1186\/s12974-025-03434-2<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the various regions of the human body has numerous roles in different physiological processes such as nutrition, metabolism, immune regulation, etc. [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":2922,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2921","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gut microbiota and their influence in brain cancer milieu - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gut microbiota and their influence in brain cancer milieu - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Abstract Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the various regions of the human body has numerous roles in different physiological processes such as nutrition, metabolism, immune regulation, etc. [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-03T03:15:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-06T02:07:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Woon Fei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Woon Fei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\"},\"author\":{\"name\":\"Woon Fei\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/ea3ccd10ab2f2bba51fd804396287cb0\"},\"headline\":\"Gut microbiota and their influence in brain cancer milieu\",\"datePublished\":\"2025-06-03T03:15:05+00:00\",\"dateModified\":\"2025-06-06T02:07:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\"},\"wordCount\":213,\"publisher\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#organization\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg\",\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\",\"name\":\"Gut microbiota and their influence in brain cancer milieu - Pharmacology\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg\",\"datePublished\":\"2025-06-03T03:15:05+00:00\",\"dateModified\":\"2025-06-06T02:07:13+00:00\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg\",\"contentUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg\",\"width\":1280,\"height\":720},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/\",\"name\":\"Pharmacology\",\"description\":\"Just another WordPress site\",\"publisher\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/medphc\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#organization\",\"name\":\"Pharmacology\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2022\/06\/logo.png\",\"contentUrl\":\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2022\/06\/logo.png\",\"width\":467,\"height\":69,\"caption\":\"Pharmacology\"},\"image\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/ea3ccd10ab2f2bba51fd804396287cb0\",\"name\":\"Woon Fei\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/fd821aa4493bddccb2a18a5acbef6f52322488bae5bf51dc8d7ea216d7fe4c8c?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/fd821aa4493bddccb2a18a5acbef6f52322488bae5bf51dc8d7ea216d7fe4c8c?s=96&d=mm&r=g\",\"caption\":\"Woon Fei\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Gut microbiota and their influence in brain cancer milieu - Pharmacology","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/","og_locale":"en_US","og_type":"article","og_title":"Gut microbiota and their influence in brain cancer milieu - Pharmacology","og_description":"Abstract Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the various regions of the human body has numerous roles in different physiological processes such as nutrition, metabolism, immune regulation, etc. [&hellip;]","og_url":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/","og_site_name":"Pharmacology","article_published_time":"2025-06-03T03:15:05+00:00","article_modified_time":"2025-06-06T02:07:13+00:00","og_image":[{"width":1280,"height":720,"url":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg","type":"image\/jpeg"}],"author":"Woon Fei","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Woon Fei","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#article","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/"},"author":{"name":"Woon Fei","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/ea3ccd10ab2f2bba51fd804396287cb0"},"headline":"Gut microbiota and their influence in brain cancer milieu","datePublished":"2025-06-03T03:15:05+00:00","dateModified":"2025-06-06T02:07:13+00:00","mainEntityOfPage":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/"},"wordCount":213,"publisher":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#organization"},"image":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage"},"thumbnailUrl":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg","articleSection":["Publications"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/","url":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/","name":"Gut microbiota and their influence in brain cancer milieu - Pharmacology","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#website"},"primaryImageOfPage":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage"},"image":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage"},"thumbnailUrl":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg","datePublished":"2025-06-03T03:15:05+00:00","dateModified":"2025-06-06T02:07:13+00:00","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/gut-microbiota-and-their-influence-in-brain-cancer-milieu\/#primaryimage","url":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg","contentUrl":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2025\/06\/20250501-GS.jpg","width":1280,"height":720},{"@type":"WebSite","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#website","url":"https:\/\/medicine.nus.edu.sg\/medphc\/","name":"Pharmacology","description":"Just another WordPress site","publisher":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicine.nus.edu.sg\/medphc\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#organization","name":"Pharmacology","url":"https:\/\/medicine.nus.edu.sg\/medphc\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/logo\/image\/","url":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2022\/06\/logo.png","contentUrl":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2022\/06\/logo.png","width":467,"height":69,"caption":"Pharmacology"},"image":{"@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/ea3ccd10ab2f2bba51fd804396287cb0","name":"Woon Fei","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/medphc\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/fd821aa4493bddccb2a18a5acbef6f52322488bae5bf51dc8d7ea216d7fe4c8c?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fd821aa4493bddccb2a18a5acbef6f52322488bae5bf51dc8d7ea216d7fe4c8c?s=96&d=mm&r=g","caption":"Woon Fei"}}]}},"_links":{"self":[{"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/posts\/2921","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/users\/9345"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/comments?post=2921"}],"version-history":[{"count":2,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/posts\/2921\/revisions"}],"predecessor-version":[{"id":2933,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/posts\/2921\/revisions\/2933"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/media\/2922"}],"wp:attachment":[{"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/media?parent=2921"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/categories?post=2921"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/medphc\/wp-json\/wp\/v2\/tags?post=2921"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}