{"id":2589,"date":"2024-05-28T06:37:26","date_gmt":"2024-05-28T06:37:26","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=2589"},"modified":"2024-12-20T06:40:12","modified_gmt":"2024-12-20T06:40:12","slug":"targeting-reprogrammed-metabolism-as-a-therapeutic-approach-for-respiratory-diseases","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/targeting-reprogrammed-metabolism-as-a-therapeutic-approach-for-respiratory-diseases\/","title":{"rendered":"Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases"},"content":{"rendered":"\r\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-2590\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20240330-FW-300x169.jpg\" alt=\"\" width=\"950\" height=\"535\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20240330-FW-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20240330-FW-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20240330-FW-768x432.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20240330-FW.jpg 1280w\" sizes=\"auto, (max-width: 950px) 100vw, 950px\" \/><\/p>\r\n<p><span style=\"font-size: 18pt;\"><strong>ABSTRACT<\/strong><\/span><\/p>\r\n<div id=\"as010\">\r\n<div id=\"sp0010\" class=\"u-margin-s-bottom\">Metabolic reprogramming underlies the etiology and <a class=\"topic-link\" title=\"Learn more about pathophysiology from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pathophysiology\">pathophysiology<\/a> of <a class=\"topic-link\" title=\"Learn more about respiratory diseases from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/respiratory-tract-disease\">respiratory diseases<\/a> such as asthma, <a class=\"topic-link\" title=\"Learn more about idiopathic pulmonary fibrosis from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/fibrosing-alveolitis\">idiopathic pulmonary fibrosis<\/a> (IPF), and <a class=\"topic-link\" title=\"Learn more about chronic obstructive pulmonary disease from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/chronic-obstructive-lung-disease\">chronic obstructive pulmonary disease<\/a> (COPD). The dysregulated cellular activities driving <a class=\"topic-link\" title=\"Learn more about airway inflammation from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/respiratory-tract-inflammation\">airway inflammation<\/a> and remodelling in these diseases have reportedly been linked to aberrant shifts in energy-producing metabolic pathways: glycolysis and <a class=\"topic-link\" title=\"Learn more about oxidative phosphorylation from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/oxidative-phosphorylation\">oxidative phosphorylation<\/a> (OXPHOS). The rewiring of glycolysis and OXPHOS accompanying the therapeutic effects of many clinical compounds and <a class=\"topic-link\" title=\"Learn more about natural products from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/natural-product\">natural products<\/a> in asthma, IPF, and COPD, supports targeting metabolism as a therapeutic approach for respiratory diseases. Correspondingly, inhibiting glycolysis has largely attested effective against <a class=\"topic-link\" title=\"Learn more about experimental asthma from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/experimental-asthma\">experimental asthma<\/a>, IPF, and COPD. However, modulating OXPHOS and its supporting catabolic pathways like mitochondrial <a class=\"topic-link\" title=\"Learn more about pyruvate from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/pyruvic-acid\">pyruvate<\/a> catabolism, fatty acid \u03b2-oxidation (FAO), and <a class=\"topic-link\" title=\"Learn more about glutaminolysis from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/glutaminolysis\">glutaminolysis<\/a> for these respiratory diseases remain inconclusive. An emerging repertoire of metabolic <a class=\"topic-link\" title=\"Learn more about enzymes from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/enzyme\">enzymes<\/a> are also interconnected to these canonical metabolic pathways that similarly possess therapeutic potential for respiratory diseases. Taken together, this review highlights the urgent demand for future studies to ascertain the role of OXPHOS in different respiratory diseases, under different stimulatory conditions, and in different cell types. While this review provides strong experimental evidence in support of the inhibition of glycolysis for asthma, IPF, and COPD, further verification by <a class=\"topic-link\" title=\"Learn more about clinical trials from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/clinical-trial\">clinical trials<\/a> is definitely required.<\/div>\r\n<\/div>\r\n<p>&nbsp;<\/p>\r\n<p>Full article:<a href=\"https:\/\/doi.org\/10.1016\/j.bcp.2024.116187\">https:\/\/doi.org\/10.1016\/j.bcp.2024.116187<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>ABSTRACT Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD). The dysregulated cellular activities driving airway inflammation and remodelling in these diseases have reportedly been linked to aberrant shifts in energy-producing metabolic pathways: glycolysis and oxidative phosphorylation (OXPHOS). The rewiring of [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":2590,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/targeting-reprogrammed-metabolism-as-a-therapeutic-approach-for-respiratory-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT Metabolic reprogramming underlies the etiology and pathophysiology of respiratory diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and chronic obstructive pulmonary disease (COPD). 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