{"id":2519,"date":"2024-12-02T06:58:07","date_gmt":"2024-12-02T06:58:07","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=2519"},"modified":"2024-12-02T06:58:07","modified_gmt":"2024-12-02T06:58:07","slug":"pro-resolving-lipid-mediators-and-therapeutic-innovations-in-resolution-of-inflammation","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/pro-resolving-lipid-mediators-and-therapeutic-innovations-in-resolution-of-inflammation\/","title":{"rendered":"Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation"},"content":{"rendered":"\r\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-2520\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20241202-PHY-300x169.jpg\" alt=\"\" width=\"760\" height=\"428\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20241202-PHY-300x169.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20241202-PHY-1024x576.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20241202-PHY-768x432.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/12\/20241202-PHY.jpg 1280w\" sizes=\"auto, (max-width: 760px) 100vw, 760px\" \/><\/p>\r\n<p><span style=\"font-size: 18pt;\"><strong>ABSTRACT<\/strong><\/span><\/p>\r\n<p>This review summarizes findings presented at the 19th World Congress of Basic &amp; Clinical Pharmacology 2023 (Glasgow, Scotland, July 3rd to 7th, 2023) from 8 speakers in the field of resolution of inflammation, resolution pharmacology and resolution biology. It is now accepted that the acute inflammatory response is protective to defend the host against infection or tissue injury. Acute inflammation is self-limited and programmed to be lim-ited in space and time: this is achieved through endogenous resolution processes that ensure return to homeo-stasis. Resolution is brought about by agonist mediators that include specialized pro-resolving lipid mediators (SPMs) and pro-resolving proteins and peptides such as annexin A1 and angiotensin-(1\u20137), all acting to initiate anti-inflammatory and pro-resolving processes. If the inflammatory reaction remains unchecked through dys-functional resolution mechanism, it can become chronic and contribute to a plethora of human diseases, includ-ing respiratory, cardiovascular, metabolic, allergic diseases, and arthritis. Herein, we discuss how non-resolving inflammation plays a role in the pathogenesis of these diseases. In addition to SPMs, we highlight the discovery, biosynthesis, biofunctions, and latest research updates on innovative therapeutics (including annexin-A1 peptide-mimetic RTP-026, small molecule FPR2 agonist BM-986235\/LAR-1219, biased agonist for FPR1\/FPR2 Cmpd17b, lipoxin mimetics AT-01-KG and AT-02-CT, melanocortin receptor agonist AP1189, gold nanoparticles, angiotensin-(1\u20137), and CD300a) that can promote resolution of inflammation directly or through modulation of SPMs production. Drug development strategies based on the biology of the resolution of inflammation can offer novel therapeutic means and\/or add-on therapies for the treatment of chronic diseases.<\/p>\r\n<p>&nbsp;<\/p>\r\n<p>Full article:<a href=\"https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108753\">https:\/\/doi.org\/10.1016\/j.pharmthera.2024.108753<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>ABSTRACT This review summarizes findings presented at the 19th World Congress of Basic &amp; Clinical Pharmacology 2023 (Glasgow, Scotland, July 3rd to 7th, 2023) from 8 speakers in the field of resolution of inflammation, resolution pharmacology and resolution biology. It is now accepted that the acute inflammatory response is protective to defend the host against [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":2520,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2519","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/pro-resolving-lipid-mediators-and-therapeutic-innovations-in-resolution-of-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT This review summarizes findings presented at the 19th World Congress of Basic &amp; Clinical Pharmacology 2023 (Glasgow, Scotland, July 3rd to 7th, 2023) from 8 speakers in the field of resolution of inflammation, resolution pharmacology and resolution biology. 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