{"id":1709,"date":"2024-01-15T02:43:15","date_gmt":"2024-01-15T02:43:15","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=1709"},"modified":"2024-12-20T06:41:21","modified_gmt":"2024-12-20T06:41:21","slug":"direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\/","title":{"rendered":"Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor"},"content":{"rendered":"\r\n<p><span style=\"font-size: 18pt;\"><strong>Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor<br \/><span style=\"font-size: 12pt;\">Caroline S\u00e9voz-Couche, Wupeng Liao, Hazel Y. C. Foo, <\/span><span style=\"font-size: 12pt;\">Isabelle Bonne, Thong Beng Lu, Caris Tan Qi Hui, <\/span><span style=\"font-size: 12pt;\">Wendy Yen Xian Peh, Shi-Cheng Yen, W. S. Fred Wong<\/span><br \/><\/strong><\/span><\/p>\r\n<p><strong>Background and Purpose:<\/strong> Asthma is characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness. The use of nicotinic agents to mimic the cholinergic anti-inflammatory pathway (CAP) controls experimental asthma. Yet, the effects of vagus nerve stimulation (VNS)-induced CAP on allergic inflammation remain unknown.<\/p>\r\n<p><strong>Experimental Approach:<\/strong> BALB\/c mice were sensitized and challenged with house dust mite (HDM) extract and treated with active VNS (5 Hz, 0.5 ms, 0.05\u20131 mA). Bronchoalveolar lavage (BAL) fluid was assessed for total and differential cell counts and cytokine levels. Lungs were examined by histopathology and electron microscopy.<\/p>\r\n<p><strong>Key Results:<\/strong> In the HDM mouse asthma model, VNS at intensities equal to or above 0.1 mA (VNS 0.1) but not sham VNS reduced BAL fluid differential cell counts and alveolar macrophages expressing \u03b17 nicotinic receptors (\u03b17nAChR), goblet cell hyperplasia, and collagen deposition. Besides, VNS 0.1 also abated HDM-induced elevation of type 2 cytokines IL-4 and IL-5 and was found to block the phosphorylation of transcription factor STAT6 and expression level of IRF4 in total lung lysates. Finally, VNS 0.1 abrogated methacholine-induced hyperresponsiveness in asthma mice. Prior administration of \u03b1-bungarotoxin, a specific inhibitor of \u03b17nAChR, but not propranolol, a specific inhibitor of \u03b22-adrenoceptors, abolished the therapeutic effects of<br \/>VNS 0.1.<\/p>\r\n<p><strong>Conclusion and Implications:<\/strong> Our data revealed the protective effects of VNS on various clinical features in allergic airway inflammation model. VNS, a clinically approved therapy for depression and epilepsy, appears to be a promising new strategy for controlling allergic asthma.<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptorCaroline S\u00e9voz-Couche, Wupeng Liao, Hazel Y. C. Foo, Isabelle Bonne, Thong Beng Lu, Caris Tan Qi Hui, Wendy Yen Xian Peh, Shi-Cheng Yen, W. S. Fred Wong Background and Purpose: Asthma is characterized by airway inflammation, mucus hypersecretion, and [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":1710,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-\u03b17-nicotinic-acetylcholine-receptor\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptorCaroline S\u00e9voz-Couche, Wupeng Liao, Hazel Y. C. Foo, Isabelle Bonne, Thong Beng Lu, Caris Tan Qi Hui, Wendy Yen Xian Peh, Shi-Cheng Yen, W. S. Fred Wong Background and Purpose: Asthma is characterized by airway inflammation, mucus hypersecretion, and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/publications\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-\u03b17-nicotinic-acetylcholine-receptor\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmacology\" \/>\n<meta property=\"article:published_time\" content=\"2024-01-15T02:43:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-20T06:41:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/04\/20240430-FW-title.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1654\" \/>\n\t<meta property=\"og:image:height\" content=\"652\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Woon Fei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Woon Fei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/\"},\"author\":{\"name\":\"Woon Fei\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#\\\/schema\\\/person\\\/ea3ccd10ab2f2bba51fd804396287cb0\"},\"headline\":\"Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor\",\"datePublished\":\"2024-01-15T02:43:15+00:00\",\"dateModified\":\"2024-12-20T06:41:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/\"},\"wordCount\":292,\"publisher\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/wp-content\\\/uploads\\\/sites\\\/33\\\/2024\\\/04\\\/20240430-FW-title.jpg\",\"articleSection\":[\"Publications\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/\",\"url\":\"https:\\\/\\\/medicine.nus.edu.sg\\\/medphc\\\/publications\\\/direct-vagus-nerve-stimulation-a-new-tool-to-control-allergic-airway-inflammation-through-%ce%b17-nicotinic-acetylcholine-receptor\\\/\",\"name\":\"Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through \u03b17 nicotinic acetylcholine receptor - 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