{"id":1626,"date":"2024-02-21T08:18:07","date_gmt":"2024-02-21T08:18:07","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=1626"},"modified":"2024-02-22T07:22:09","modified_gmt":"2024-02-22T07:22:09","slug":"modifying-brain-molecule-relaxin-3-can-potentially-reduce-side-effects-in-treating-anxiety-depression-and-more","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/news\/modifying-brain-molecule-relaxin-3-can-potentially-reduce-side-effects-in-treating-anxiety-depression-and-more\/","title":{"rendered":"Modifying brain molecule relaxin-3 can potentially reduce side effects in treating anxiety, depression and more"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1635\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01-300x133.png\" alt=\"\" width=\"300\" height=\"133\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01-300x133.png 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01-1024x453.png 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01-768x340.png 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01-1536x680.png 1536w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2024\/02\/gavin_figures_v01-01.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Drugs that treat conditions like depression and anxiety often come with varying side effects, as they regulate various functions within the human body at the same time. What if these drugs\u00a0 could activate only the functions that target the specific conditions that they are designed to treat?<\/p>\n<p>A team of researchers has found a potential way to treat these conditions with fewer side effects. Led by Professor Gavin Dawe, Head of the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), the team conducted modifications of relaxin-3\u2014a neuropeptide, or molecule, found mainly in the human brain and nervous system\u2014which regulates a wide range of physiological functions, including stress responses, appetite, mood and pain perception. When relaxin-3 is released in the brain, it binds to a target receptor RXFP3\u2014to trigger a variety of signalling responses among the cells, which affect the body\u2019s physiological processes.<\/p>\n<p>For more details: <a href=\"https:\/\/medicine.nus.edu.sg\/wp-content\/uploads\/2024\/02\/2024-02-19-Press-Release-Modifying-Relaxin-3-can-potentially-reduce-side-effects_final.pdf\">https:\/\/medicine.nus.edu.sg\/wp-content\/uploads\/2024\/02\/2024-02-19-Press-Release-Modifying-Relaxin-3-can-potentially-reduce-side-effects_final.pdf<\/a><\/p>\n<p><em>Image credit: Office of the Deputy President (Research and Technology)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drugs that treat conditions like depression and anxiety often come with varying side effects, as they regulate various functions within the human body at the same time. What if these drugs\u00a0 could activate only the functions that target the specific conditions that they are designed to treat? A team of researchers has found a potential [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":1633,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1626","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Modifying brain molecule relaxin-3 can potentially reduce side effects in treating anxiety, depression and more - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/news\/modifying-brain-molecule-relaxin-3-can-potentially-reduce-side-effects-in-treating-anxiety-depression-and-more\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modifying brain molecule relaxin-3 can potentially reduce side effects in treating anxiety, depression and more - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"Drugs that treat conditions like depression and anxiety often come with varying side effects, as they regulate various functions within the human body at the same time. What if these drugs\u00a0 could activate only the functions that target the specific conditions that they are designed to treat? 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