{"id":1566,"date":"2023-12-08T02:41:46","date_gmt":"2023-12-08T02:41:46","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/medphc\/?p=1566"},"modified":"2023-12-08T02:41:46","modified_gmt":"2023-12-08T02:41:46","slug":"nano-sized-cell-particles-are-promising-intervention-tools-in-treating-infectious-diseases","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/medphc\/news\/nano-sized-cell-particles-are-promising-intervention-tools-in-treating-infectious-diseases\/","title":{"rendered":"Nano-sized Cell Particles are Promising Intervention Tools in Treating Infectious Diseases"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-1568\" src=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2023\/12\/MLE-lab-300x225.jpg\" alt=\"\" width=\"352\" height=\"264\" srcset=\"https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2023\/12\/MLE-lab-300x225.jpg 300w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2023\/12\/MLE-lab-1024x768.jpg 1024w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2023\/12\/MLE-lab-768x576.jpg 768w, https:\/\/medicine.nus.edu.sg\/medphc\/wp-content\/uploads\/sites\/33\/2023\/12\/MLE-lab.jpg 1536w\" sizes=\"auto, (max-width: 352px) 100vw, 352px\" \/><\/p>\n<p><em>Authors of the study, from NUS Medicine: (Back row, from left) Assoc Prof Justin Chu, Dr. Kai Sen Tan, <\/em><em>Migara Jayasinghe (Pharmacology), <\/em><em>Dr.<\/em><em> Dai Cao Phung (Pharmacology), Brendon Zhi Jie Yeo (Pharmacology); (F<\/em><em>ront row, from left) Asst Prof Minh Le (Pharmacology), Gao Chang (Pharmacology), Rebecca Carissa Prajogo (Pharmacology).<\/em><\/p>\n<p>The COVID-19 pandemic demonstrated the importance of being prepared with drug interventions to contain viral outbreaks that can otherwise have devastating consequences. In preparing for the next pandemic\u2014or Disease X, there is an urgent need for versatile platform technologies that could be repurposed upon short notice, to combat infectious outbreaks.<\/p>\n<p>A team of researchers, led by <strong>Assistant Professor Minh Le<\/strong> from the Institute for Digital Medicine (WisDM) and <strong>Department of Pharmacology<\/strong> at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), discovered that nano-sized particles released by cells, termed \u201cextracellular vesicles\u201d (EVs), can curb the viral infectivity of SARS-CoV-2\u2014its wild type and variant strains\u2014and potentially other infectious diseases. Asst Prof Le said, \u201cOur study showed that these cell-derived nanoparticles are effective carriers of drugs that target viral genes precisely. These EVs are therefore an efficient tool for therapeutic intervention in patients who are infected with COVID-19 or other infectious diseases.\u201d<\/p>\n<p>The study, conducted in collaboration with NUS Medicine\u2019s Biosafety Level 3 (BSL3) Core Facility, the Cancer Science Institute of Singapore, and the School of Physical and Mathematical Sciences at Nanyang Technological University (NTU), demonstrated potent inhibition of COVID-19 infection in laboratory models using a combination of EV-based inhibition and anti-sense RNA therapy mediated by <em>antisense oligonucleotides<\/em> (ASOs).<\/p>\n<p>Read more: <a href=\"https:\/\/medicine.nus.edu.sg\/news\/nano-sized-cell-particles-are-promising-intervention-tool-in-treating-infectious-diseases\/\">https:\/\/medicine.nus.edu.sg\/news\/nano-sized-cell-particles-are-promising-intervention-tool-in-treating-infectious-diseases\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Authors of the study, from NUS Medicine: (Back row, from left) Assoc Prof Justin Chu, Dr. Kai Sen Tan, Migara Jayasinghe (Pharmacology), Dr. Dai Cao Phung (Pharmacology), Brendon Zhi Jie Yeo (Pharmacology); (Front row, from left) Asst Prof Minh Le (Pharmacology), Gao Chang (Pharmacology), Rebecca Carissa Prajogo (Pharmacology). The COVID-19 pandemic demonstrated the importance [&hellip;]<\/p>\n","protected":false},"author":9345,"featured_media":1568,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[4],"tags":[],"class_list":["post-1566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nano-sized Cell Particles are Promising Intervention Tools in Treating Infectious Diseases - Pharmacology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/medphc\/news\/nano-sized-cell-particles-are-promising-intervention-tools-in-treating-infectious-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nano-sized Cell Particles are Promising Intervention Tools in Treating Infectious Diseases - Pharmacology\" \/>\n<meta property=\"og:description\" content=\"&nbsp; Authors of the study, from NUS Medicine: (Back row, from left) Assoc Prof Justin Chu, Dr. Kai Sen Tan, Migara Jayasinghe (Pharmacology), Dr. Dai Cao Phung (Pharmacology), Brendon Zhi Jie Yeo (Pharmacology); (Front row, from left) Asst Prof Minh Le (Pharmacology), Gao Chang (Pharmacology), Rebecca Carissa Prajogo (Pharmacology). 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