Research

Our multidisciplinary approach ensures that individuals from different segments of society are resilient to extreme heat.

As such, our research covers all aspects pertaining to heat on human health, safety, and well-being.

Discover Novel Heat
Mechanisms

Outcome

Develop innovative tools and capabilities that transform and interpret heat data into knowledge

Research Focus

  • Causative Mechanisms
  • Predictive Factors
  • Biomarkers

Research Areas Include

  • Pathophysiology
  • Epidemiology
  • Data Analytics
  • Artificial Intelligence
  • Modelling & Simulation

Detect

Detect Heat Health
Readiness

Outcome

Create agile systems to visualise, sense-make and manage human heat health status

Research Focus

  • Heat Prediction & Prevention
  • Heat Health Assessment

Research Areas Include

  • Thermal & Exercise Physiology
  • Systems Biology
  • Behavourial Science

Discover

Strengthen

Strengthen Human
Heat Resilience

Outcome

Explore new and novel heat mitigation and management strategies

Research Focus

  • Heat Recovery
  • Behavioural Strategies
  • Microclimate Cooling

Research Areas Include

  • Materials Science
  • Nutrition
  • Design & Engineering
  • Psycho-physiology

Detect

Publications

Article Title Authors Year Journal
Effects of Heat Exposure and Ice Slurry Ingestion on Risk-Taking Behavior in Healthcare Workers Sharifah Badriyah Alhadad, R. Ponampalam, Louisa Si Xian Lim,... Jason Kai Wei Lee 2024 Medicine and Science in Sports and Exercise
Climate change and population health in Singapore: a systematic review. Joel Aik, Lina Ang, Samuel H. Gunther,... Wei Jie Seow 2023 The Lancet Regional Health - Western Pacific
The effects of low and normal dose ice slurry ingestion on endurance capacity and intestinal epithelial injury in the heat Sharifah B. Alhadad, Melissa C.Y. Chua, Jason K.W. Lee and Ivan C.C. Low 2023 Journal of Science and Medicine in Sport
Continuous Thermoregulatory Responses to a Mass-Participation 89-km Ultramarathon Road Race Christopher Byrne, Aurelien Cosnefroy, Roger Eston,... Tim Noakes 2022 International Journal of Sports Physiology and Performance
Different perspectives on women’s health, nutrition and endurance exercise Nisha Charkoudian, Jason K.W. Lee, Gabrielle E.W. Giersch,... Nina Stachenfeld 2023 Journal of the International Society of Sports Nutrition
Effect of ice slurry ingestion on thermoregulatory responses during fixed-intensity cycling in humid and dry heat Hui Cheng Choo, Darine Hui Wen Choo, Isabelle Tan,... Mohammed Ihsan 2023 European Journal of Applied Physiology
Redirecting immune, lipid, and metabolic drivers of early cardiovascular disease: the RESET cohort study and randomized trial Mayank Dalakoti, Roger Foo, the RESET Consortium,... Boxiang Liu 2023 European Heart Journal
Impact of heat on all-cause and cause-specific mortality: A multi-city study in Texas Chunyu Guo, Kevin Lanza, Dongying Li,... Kai Zhang 2023 Environmental Research
Delineating the impacts of air temperature and humidity for endurance exercise Elliott J. Jenkins, Holly A. Campbell,... James D. Cotter 2023 Experimental Physiology
Assessment of Changes in Physiological Markers in Different Body Fluids at Rest and after Exercise Amalini Jesuthasan, Ajmol Ali, Jason Kai Wei Lee and Kay Rutherfurd-Markwick 2022 Nutrients
Biomarkers for warfighter safety and performance in hot and cold environments Jason K.W. Lee, Beverly Tan, Boris R.M. Kingma,... Yoram Epstein 2023 Journal of Science and Medicine in Sport
Exertional heat stroke: nutritional considerations Jason K. W. Lee, Beverly Tan, Henry B. Ogden,... Michael N. Sawka 2022 Experimental Physiology
Stochastic Exceptional Points for Noise-Assisted Sensing Zhipeng Li, Chenhui Li, Ze Xiong,... Cheng-Wei Qiu 2023 Physical Review Letters
Transient thermal and physiological responses from air-conditioned room to semi-outdoor space in the tropics Kuniaki Mihara, Shisheng Chen, Takamasa Hasama,... Nyuk Hien Wong 2022 Building and Environment
Integrated Assessment of Urban Overheating Impacts on Human Life N. Nazarian, E. S. Krayenhoff, B. Bechtel, D. M. Hondula,... M. Santamouris 2022 Earth's Future
Study on indoor thermal perception, behavioral adaptation in late pregnancy and their effects on adverse birth outcomes in south China Jie Ni, Huailin Wang, Xinyue Yu,... Qiong Wang 2024 Building and Environment
Practical internal and external cooling methods do not influence rapid recovery from simulated taekwondo performance Pariya Pariyavuth, Jason Kai Wei Lee, Pearl Min Sze Tan,... Metta Pinthong 2023 Journal of Exercise Science & Fitness
Mixed-methods clinical trial to evaluate the feasibility of the CURATE.AI optimised digital cognitive rehabilitation therapeutic (COR-Tx) in patients post brain radiotherapy. Marlena N. Raczkowska, Alexandria Remus, Smrithi Vijayakumar,... Balamurugan A. Vellayappan 2023 Journal of Clinical Oncology
Appendix A. AI and Its Potential Use in DTx: A Brief Overview of Frequently Asked Questions Alexandria Remus 2023 Johns Hopkins University Press
CURATE.AI COR-Tx platform as a digital therapy and digital diagnostic for cognitive function in patients with brain tumour postradiotherapy treatment: protocol for a prospective mixed-methods feasibility clinical trial Alexandria Remus, Xavier Tadeo, Grady Ng Shi Kai,... Balamurugan A Vellayappan 2023 BMJ Open
The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels Marina Romanello, Claudia Di Napoli, Paul Drummond, ...Anthony Costello 2022 The Lancet
The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms Marina Romanello, Claudia di Napoli, Carole Green,... Anthony Costello 2023 The Lancet
Economic Evaluation Associated With Clinical-Grade Mobile App–Based Digital Therapeutic Interventions: Systematic Review Yoann Sapanel, Xavier Tadeo, Connor T A Brenna,... Dean Ho 2023 Journal of Medical Internet Research
A History of Heat Health Management Policies in the Singapore Military Joshua Dao Wei Sim and Jason Kai Wei Lee 2023 Healthcare
Digital game-based interventions for cognitive training in healthy adults and adults with cognitive impairment: protocol for a two-part systematic review and meta-analysis Shi-Bei Tan, Joshua Tan, Marlena N Raczkowska,... Dean Ho 2023 BMJ Open
Pre-exercise hot water immersion increased circulatory heat shock proteins but did not alter muscle damage markers or endurance capacity after eccentric exercise Xiang Ren Tan, Ivan C. C. Low, Tuck Wah Soong and Jason K. W. Lee 2024 Temperature
Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function Xiang Ren Tan, Mary C. Stephenson, Sharifah Badriyah Alhadad,... Ivan C.C. Low 2024 Journal of Sport and Health Science
Enhancing physical performance with machine learning Trinh C.K. Tran, Yongtai Raymond Wang, Alexandria Remus,... Jason Kai Wei Lee 2022 Institution of Engineering and Technology
Thermal perception and lung function: a panel study in young adults with exercise under high outdoor temperature Huailin Wang, Cho Kwong Charlie Lam, Maimaitiminjiang Wulayin,... Qiong Wang 2023 International Journal of Biometeorology
N-of-1 medicine Peter Wang, Qiao Ying Leong, Ni Yin Lau,... Dean Ho 2024 Singapore Medical Journal
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming Jericho Wee, Xiang Ren Tan, Samuel H. Gunther,... Jason Kai Wei Lee 2023 Pharmacological Reviews
Poor personal protective equipment practices were associated with heat-related symptoms among Asian healthcare workers: a large-scale multi-national questionnaire survey Hsiao-Yu Yang, Hsiu-Ling Chou, Clarence Hong Wei Leow,... Jason Kai Wei Lee 2024 BMC Nursing
Labour productivity and economic impacts of carbon mitigation: a modelling study and benefit–cost analysis Mengzhen Zhao, Xiaodan Huang, Tord Kjellstrom,... Wenjia Cai 2022 The Lancet Planetary Health

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