Research
Our multidisciplinary approach ensures that individuals from different segments of society are resilient to extreme heat.
As such, our research covers all aspects pertaining to heat on human health, safety, and well-being.
Discover Novel Heat
Mechanisms
Outcome
Develop innovative tools and capabilities that transform and interpret heat data into knowledge
Research Focus
- Causative Mechanisms
- Predictive Factors
- Biomarkers
Research Areas Include
- Pathophysiology
- Epidemiology
- Data Analytics
- Artificial Intelligence
- Modelling & Simulation
Detect Heat Health
Readiness
Outcome
Create agile systems to visualise, sense-make and manage human heat health status
Research Focus
- Heat Prediction & Prevention
- Heat Health Assessment
Research Areas Include
- Thermal & Exercise Physiology
- Systems Biology
- Behavourial Science
Strengthen Human
Heat Resilience
Outcome
Explore new and novel heat mitigation and management strategies
Research Focus
- Heat Recovery
- Behavioural Strategies
- Microclimate Cooling
Research Areas Include
- Materials Science
- Nutrition
- Design & Engineering
- Psycho-physiology
Publications
| Article Title | Authors | Year | Journal |
|---|---|---|---|
| Towards a decolonial heat-health nexus: Disrupters, enablers and energy properties of heat from the 19th century to the present day | Joshua Dao-Wei Sim, Laurie Parsons | 2025 | Social Science and Medicine |
| Examining the Physiological Strain with Electric Fans During High Indoor Heat Stress | Emily Mihalcin, Stefano Schiavon, Nicholas Ravanelli | 2025 | Building and Environment |
| Head, Face, and Neck Cooling for Performance: A Systematic Review and Meta-Analysis | Christopher J Stevens, David Borg, Carly Brade, Sarah Carter, Davide Filingeri, Jason Lee, Louisa Lim...Christopher J Tyler | 2025 | International journal of sports physiology and performance |
| Perceived impact of heat stress on health and productivity of tropical female garment workers–a comparison between cool and hot months | Vabotra Chea, Sarin Chan, Natalia Borzino, Min Sze Pearl Tan, Jason Kai Wei Lee, Kinnaleth Vongchanh | 2025 | BMC Public Health |
| Exertional heat illness: international military-oriented lessons learned and best practices for prevention and management | Yoram Epstein, Nisha Charkoudian, David W DeGroot...Jason Kai Wei Lee | 2025 | Frontiers in Physiology |
| The effect of hypohydration before and different rehydration strategies after severe intensity exercise on post-exercise hypotension in men | Tze-Huan Lei, Xia Wei, Faming Wang, Jingliang Chen, Richie Goulding, James Cotter, Jason Kai Wei Lee...Toby Mündel | 2025 | European journal of applied physiology |
| Advancing heat wave definitions: A policy review towards prioritizing health impacts of extreme heat | Sai Venkata Sarath Chandra N, Samuel H Gunther, Tord Kjellstrom, Jason Kai Wei Lee | 2025 | Environmental Research Letters |
| Physical Work in Humid Heat Impairs Postural Balance during Simulated Construction Tasks at Height | Beverly Wei Lin Tan, Sharifah Badriyah Alhadad, Gerald Zheng Yang Tan, Pearl Min Sze Tan, Bruno Lemke, Jason Kai Wei Lee | 2025 | Medicine and Science in Sports and Exercise |
| Humid heat exceeds human tolerance limits and causes mass mortality | Tom Matthews, Emma E Ramsay, Fahad Saeed,... Andrew Forrest | 2025 | Nature Climate Change |
| The 2024 report of the Lancet Countdown on health and climate change: facing record-breaking threats from delayed action | Marina Romanello, Maria Walawender, Shih-Che Hsu,... Anthony Costello | 2024 | The Lancet |
| Endocrine effects of heat exposure and relevance to climate change | Fadil M Hannan, Melvin KS Leow, Jason KW Lee,... Rajesh V Thakker | 2024 | Nature Reviews Endocrinology |
| Occupational Heat Effects: A Global Health and Economic Threat | Colin D Butler, Jason KW Lee, Subhashis Sahu, Tord Kjellstrom | 2024 | Book: Climate Change and Global Health: Primary, Secondary and Tertiary Effects |
| Effects of Heat Exposure and Ice Slurry Ingestion on Risk-Taking Behavior in Healthcare Workers | Sharifah Badriyah Alhadad, R. Ponampalam, Louisa Si Xian Lim,... Jason Kai Wei Lee | 2024 | Medicine and Science in Sports and Exercise |
| Climate change and population health in Singapore: a systematic review. | Joel Aik, Lina Ang, Samuel H. Gunther,... Wei Jie Seow | 2023 | The Lancet Regional Health - Western Pacific |
| The effects of low and normal dose ice slurry ingestion on endurance capacity and intestinal epithelial injury in the heat | Sharifah B. Alhadad, Melissa C.Y. Chua, Jason K.W. Lee and Ivan C.C. Low | 2023 | Journal of Science and Medicine in Sport |
| Continuous Thermoregulatory Responses to a Mass-Participation 89-km Ultramarathon Road Race | Christopher Byrne, Aurelien Cosnefroy, Roger Eston,... Tim Noakes | 2022 | International Journal of Sports Physiology and Performance |
| Different perspectives on women’s health, nutrition and endurance exercise | Nisha Charkoudian, Jason K.W. Lee, Gabrielle E.W. Giersch,... Nina Stachenfeld | 2023 | Journal of the International Society of Sports Nutrition |
| Effect of ice slurry ingestion on thermoregulatory responses during fixed-intensity cycling in humid and dry heat | Hui Cheng Choo, Darine Hui Wen Choo, Isabelle Tan,... Mohammed Ihsan | 2023 | European Journal of Applied Physiology |
| Redirecting immune, lipid, and metabolic drivers of early cardiovascular disease: the RESET cohort study and randomized trial | Mayank Dalakoti, Roger Foo, the RESET Consortium,... Boxiang Liu | 2023 | European Heart Journal |
| Impact of heat on all-cause and cause-specific mortality: A multi-city study in Texas | Chunyu Guo, Kevin Lanza, Dongying Li,... Kai Zhang | 2023 | Environmental Research |
| Delineating the impacts of air temperature and humidity for endurance exercise | Elliott J. Jenkins, Holly A. Campbell,... James D. Cotter | 2023 | Experimental Physiology |
| Assessment of Changes in Physiological Markers in Different Body Fluids at Rest and after Exercise | Amalini Jesuthasan, Ajmol Ali, Jason Kai Wei Lee and Kay Rutherfurd-Markwick | 2022 | Nutrients |
| Biomarkers for warfighter safety and performance in hot and cold environments | Jason K.W. Lee, Beverly Tan, Boris R.M. Kingma,... Yoram Epstein | 2023 | Journal of Science and Medicine in Sport |
| Exertional heat stroke: nutritional considerations | Jason K. W. Lee, Beverly Tan, Henry B. Ogden,... Michael N. Sawka | 2022 | Experimental Physiology |
| Stochastic Exceptional Points for Noise-Assisted Sensing | Zhipeng Li, Chenhui Li, Ze Xiong,... Cheng-Wei Qiu | 2023 | Physical Review Letters |
| Transient thermal and physiological responses from air-conditioned room to semi-outdoor space in the tropics | Kuniaki Mihara, Shisheng Chen, Takamasa Hasama,... Nyuk Hien Wong | 2022 | Building and Environment |
| Integrated Assessment of Urban Overheating Impacts on Human Life | N. Nazarian, E. S. Krayenhoff, B. Bechtel, D. M. Hondula,... M. Santamouris | 2022 | Earth's Future |
| Study on indoor thermal perception, behavioral adaptation in late pregnancy and their effects on adverse birth outcomes in south China | Jie Ni, Huailin Wang, Xinyue Yu,... Qiong Wang | 2024 | Building and Environment |
| Practical internal and external cooling methods do not influence rapid recovery from simulated taekwondo performance | Pariya Pariyavuth, Jason Kai Wei Lee, Pearl Min Sze Tan,... Metta Pinthong | 2023 | Journal of Exercise Science & Fitness |
| Mixed-methods clinical trial to evaluate the feasibility of the CURATE.AI optimised digital cognitive rehabilitation therapeutic (COR-Tx) in patients post brain radiotherapy. | Marlena N. Raczkowska, Alexandria Remus, Smrithi Vijayakumar,... Balamurugan A. Vellayappan | 2023 | Journal of Clinical Oncology |
| Appendix A. AI and Its Potential Use in DTx: A Brief Overview of Frequently Asked Questions | Alexandria Remus | 2023 | Johns Hopkins University Press |
| CURATE.AI COR-Tx platform as a digital therapy and digital diagnostic for cognitive function in patients with brain tumour postradiotherapy treatment: protocol for a prospective mixed-methods feasibility clinical trial | Alexandria Remus, Xavier Tadeo, Grady Ng Shi Kai,... Balamurugan A Vellayappan | 2023 | BMJ Open |
| The 2022 report of the Lancet Countdown on health and climate change: health at the mercy of fossil fuels | Marina Romanello, Claudia Di Napoli, Paul Drummond, ...Anthony Costello | 2022 | The Lancet |
| The 2023 report of the Lancet Countdown on health and climate change: the imperative for a health-centred response in a world facing irreversible harms | Marina Romanello, Claudia di Napoli, Carole Green,... Anthony Costello | 2023 | The Lancet |
| Economic Evaluation Associated With Clinical-Grade Mobile App–Based Digital Therapeutic Interventions: Systematic Review | Yoann Sapanel, Xavier Tadeo, Connor T A Brenna,... Dean Ho | 2023 | Journal of Medical Internet Research |
| A History of Heat Health Management Policies in the Singapore Military | Joshua Dao Wei Sim and Jason Kai Wei Lee | 2023 | Healthcare |
| Digital game-based interventions for cognitive training in healthy adults and adults with cognitive impairment: protocol for a two-part systematic review and meta-analysis | Shi-Bei Tan, Joshua Tan, Marlena N Raczkowska,... Dean Ho | 2023 | BMJ Open |
| Pre-exercise hot water immersion increased circulatory heat shock proteins but did not alter muscle damage markers or endurance capacity after eccentric exercise | Xiang Ren Tan, Ivan C. C. Low, Tuck Wah Soong and Jason K. W. Lee | 2024 | Temperature |
| Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function | Xiang Ren Tan, Mary C. Stephenson, Sharifah Badriyah Alhadad,... Ivan C.C. Low | 2024 | Journal of Sport and Health Science |
| Enhancing physical performance with machine learning | Trinh C.K. Tran, Yongtai Raymond Wang, Alexandria Remus,... Jason Kai Wei Lee | 2022 | Institution of Engineering and Technology |
| Thermal perception and lung function: a panel study in young adults with exercise under high outdoor temperature | Huailin Wang, Cho Kwong Charlie Lam, Maimaitiminjiang Wulayin,... Qiong Wang | 2023 | International Journal of Biometeorology |
| N-of-1 medicine | Peter Wang, Qiao Ying Leong, Ni Yin Lau,... Dean Ho | 2024 | Singapore Medical Journal |
| Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming | Jericho Wee, Xiang Ren Tan, Samuel H. Gunther,... Jason Kai Wei Lee | 2023 | Pharmacological Reviews |
| Poor personal protective equipment practices were associated with heat-related symptoms among Asian healthcare workers: a large-scale multi-national questionnaire survey | Hsiao-Yu Yang, Hsiu-Ling Chou, Clarence Hong Wei Leow,... Jason Kai Wei Lee | 2024 | BMC Nursing |
| Labour productivity and economic impacts of carbon mitigation: a modelling study and benefit–cost analysis | Mengzhen Zhao, Xiaodan Huang, Tord Kjellstrom,... Wenjia Cai | 2022 | The Lancet Planetary Health |