![\"Dr](\"https:\/\/medicine.nus.edu.sg\/dbmi\/wp-content\/uploads\/sites\/27\/2025\/05\/Dr-Tan-for-Website.png\" "\\"Dr")
\n\tTAN Kar Tong<\/b><\/p>\n
Assistant Professor<\/p>\n
Department of Biomedical Informatics<\/p>\n\t
Qualifications<\/b><\/p>\n Awards<\/b>\u00a0<\/p>\n <\/p>\n\t\t\t\t\t\tTeaching Areas & Research Interests\n\t\t\t\t\t\t\t\t\t\t\t Computational Genomics \/ Bioinformatics\u00a0<\/p>\n <\/p>\n The advancement of high-throughput sequencing technologies has led to a deluge of sequencing data, amounting to thousands of terabytes across thousands of individuals. These massive datasets that are now widely available offer us unprecedented opportunities to delve into many complex biological questions and investigate a multitude of biological phenomena through large-scale genome mining. Specifically, leveraging these massive genomics datasets and new computational methods that we are developing, we aim to tackle the following critical biological questions:<\/p>\n Somatic genome alterations are recognized as pivotal drivers of cancer; however, many cancer patients lack detectable cancer-driving DNA alterations. It is conceivable that some of these missing alterations are hidden within the highly repetitive regions of the human genome, which traditionally pose technical challenges for analysis. To tackle this issue, we are pioneering new computational methods and harnessing advancements in long-read sequencing technologies to decipher DNA alterations within these complex regions in cancer patients.<\/p>\n The advent of RNA vaccines during the COVID-19 pandemic has underscored the efficacy of RNA technologies in therapeutics and biotechnology. This underscores the need to develop a broader array of RNA-based therapeutic strategies. In pursuit of this goal, we are utilizing large-scale genome mining to uncover valuable RNA elements, and to engineer and produce RNA therapeutics.<\/p>\n While somatic mutations are recognized as pivotal drivers of cancer, recent studies have revealed their presence in various normal tissues beyond cancer. This suggests that somatic mutations might also play significant roles in driving other age-related diseases. To address this possibility, we are developing advanced computational methods and approaches to identify these mutations in diverse tissues and to understand their role in other aging-related conditions.<\/p>\n\t\t\t\t\t\tJournals & Publications\n\t\t\t\t\t\t\t\t\t\t\tNeotelomeres and Telomere-Spanning Chromosomal Arm Fusions in Cancer Genomes Revealed by Long-Read Sequencing.<\/b> <\/p>\n *Equal Contributions<\/em><\/strong><\/p>\n –<\/p>\n More: Google Scholar<\/p>\n\n","protected":false},"excerpt":{"rendered":" TAN Kar Tong Assistant Professor Department of Biomedical Informatics LinkedIn ktan@nus.edu.sg Personal Website Brief Introduction Teaching Areas & Research Interests Journals & Publications Brief Introduction Qualifications BSc (Life Sciences and Chemistry) (Hons), National University of Singapore\u00a0MSc (Computer Science), National University of Singapore\u00a0SM (Computational Science and Engineering), Harvard University\u00a0PhD (Computational Genomics and Bioinformatics), Harvard University\u00a0 Awards\u00a0 […]<\/p>\n","protected":false},"author":9400,"featured_media":0,"parent":2595,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-3085","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n\n
MSc (Computer Science), National University of Singapore\u00a0
SM (Computational Science and Engineering), Harvard University\u00a0
PhD (Computational Genomics and Bioinformatics), Harvard University\u00a0<\/li>\n<\/ul>\n\n
Teaching Areas \/ Graduate Supervision<\/strong><\/h6>\n
Research Interests<\/strong><\/h6>\n
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\nTan, K.-T.<\/b>, Slevin, M.K., Leibowitz, M.L., Garrity-Janger, M., Li, H., and Meyerson, M.\u202fCell Genomics.\u202f<\/i>(2024).\nIdentifying and correcting repeat-calling errors in nanopore sequencing of telomeres<\/b>.
\nTan, K.T.<\/b>, Slevin, M.K., Meyerson, M., and Li, H.\u202fGenome Biol. 23, 1-16<\/i>. (2022).\u00a0\nHaplotype-resolved germline and somatic alterations in renal medullary carcinomas<\/b>.
\nTan, K.T.<\/b>, Kim, H., Carrot-Zhang, J., Zhang, Y., Kim, W.J., Kugener, G., Wala, J.A., Howard, T.P., Chi, Y.Y., Beroukhim, R., Li, H., Ha, G., Alper, S.L., Perlman, E.J., Mullen, E.A., Hahn, W.C., Meyerson, M., and Hong, A.L.\u202fGenome Med. 13<\/i>. (2021).\u00a0\nRepurposing RNA sequencing for discovery of RNA modifications in clinical cohorts<\/b>.
\nTan, K.T.<\/b>, Ding, L.W., Wu, C.S., Tenen, D.G., and Yang, H.\u202fSci. Adv. 7<\/i>. (2021).\u00a0\nProfiling the B\/T cell receptor repertoire of lymphocyte derived cell lines<\/b>.
\nTan, K.-T.*<\/b>, Ding, L.-W.*, Sun, Q.-Y.*, Lao, Z.-T., Chien, W., Ren, X., Xiao, J.-F., Loh, X.Y., Xu, L., Lill, M., Mayakonda, A., Lin, D.-C., Yang, H., and Koeffler, H.P.\u202fBMC Cancer 18<\/i>. (2018).\u00a0\n