Dr Judice Koh - Department of Biomedical Informatics

KOH, Judice

Division of Biomedical Informatics

Lecturer

Curriculum Vitae

Brief Introduction Teaching Areas/Graduate Supervision Journals & Publications

Brief Introduction

Dr. Judice Koh has more than 20 years’ experience in Data Science and Computational Biology, with specialization in Artificial intelligence in Drug Discovery. Judice received her PhD in Computer Science from National University of Singapore (NUS) in 2007. She completed her postdoctoral training in University of Toronto, Canada and subsequently assumed several pivoting roles in Genome Institute of Singapore (GIS) and Experimental Drug Development Centre (EDDC), A*STAR. Currently, she is also the co-founder of a Biotech company, and scientific advisor to Singapore Clinical Research Institute (SCRI).

Judice’s research focuses on AI and data analytic applications in drug discovery. Her expertise is in integrating AI with high-throughput microscopy to quantify cellular phenotypes in large-scale drug screens. Judice has published more than 30 research papers, including first author papers in Cell, PNAS and Nucleic Acids Research and co-author papers in Science, Nature methods, Nature Communications and Cancer Discovery. She has 2 patents to her credit.

Qualifications:

Ph.D. in Computer Science, School of Computing, NUS, 2007

M.Tech in Software Engineering, Institute of System Science, NUS, 2001

B.Sc in Computational Science with Chemistry, NUS, 1996

Awards

Lead PI for A*STAR GAP proposal. “Cellular Protein-Chemical Interaction profiling platform for Drug Discovery and Drug Target Analysis”. SGD499k for 2 years. Status: Novel platform established. Completed in Mar 2022. Platform spin-off as a Biotech startup.

Teaching Areas/Graduate Supervision

Journals & Publications

• Kong LR, Ong RWJ, Tan TZ, Thangavelu M, Chan JV, Koh JLY, Periyasamy G, Lee M, LIM CM, Chng WJ, Lane D, Venkitaraman A, Hung H, Cheok CF, and Goh BC (2021) “Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation”. Nat Commun. 11, 2086.

• Thangavelu M, Chan JV, Zhang XQ, Chia SM, Gopalakrishna Iyer N, Dasgupta R, Periysamy G, Koh JLY (Poster Presentation) “Predictive Modeling of Drug Response Kinetics in Patient-Derived Micro-Tumors using 4D High Content Screening”. EMBL Symposium: Seeing is Believing - Imaging the Processes of Life, EMBL Heidelberg, Germany, 4-7 Oct 2017.

• Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R (2017) “Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time”. Nat Commun. 2017 Sep 5;8(1):435.

• *Chong YT, *Koh JLY, Friesen H, Duffy SK, Cox MC, Moses A, Moffat J, Boone C, and Andrews B (2015) “Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis.” Cell 2015 June 4; 161(6), p1413–1424. *equal contribution

• Koh JLY, Brown KR, Sayad A, Kasimer D, Ketela T, Moffat J (2012) “COLT-Cancer: A database of essential genes in human cancer cells”. Nucleic Acids Research (NAR), 40, Database issue D957–D963.

• *Dixon SJ, *Fedyshyn Y, *Koh JLY, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe K, Kim D, Park H, Myers CL, Pandey A, Durocher D, Andrews BJ, and Boone C (2008) “Significant Conservation of Synthetic Lethal Genetic Interaction Networks between Distantly-Related Eukaryotes”. Proc. Natl. Acad. Sci. (PNAS), 105(43), pp16653-16658. *equal contribution

• Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JLY, Toufighi K, Mostafavi S et al. (2010) “The Genetic Landscape of a Cell”, Science 22, 327(5964) pp425-431.

• Baryshnikova A, Costanzo M, Kim Y, Ding H, Koh JLY, Toufighi K, Youn JY, Ou J, San Luis BJ, Bandyopadhyay S, Hibbs M, Hess D, Gingras AC, Bader GD, Troyanskaya OG, Brown GW, Andrews B, Boone C, Myers CL. (2010) “Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.” Nat Methods, 7(12), 1017-1024.

• Koh JLY, Lee ML, Hsu W, and Ang WT (2008) “Correlation-based Attribute Outlier Detection in XML”. Proceedings of the 24th International Conference on Data Engineering (ICDE), pp1522-1524.

• Koh JLY, Lee ML, Hsu W, and Lam KT (2007) “Correlation-based Detection of Attribute Outlier”. Proceedings of the12th International Conference on Database Systems for Advanced Applications (DASFAA): pp164-175.

• Zhang ZH, Koh JLY, Zhang GL, Choo KH, Tammi KT, and Tong JC (2007) “AllerTool: a Web Server for Predicting Allergenicity and Allergic Cross-reactivity in Proteins”. Bioinformatics 23(4): pp504-506.

• Hosaka J, Koh JLY, Konagaya A (2003) “Effect of Utilizing Terminology on Extraction of Protein-Protein Interaction Information from Biomedical Literature”. Proceeding of10th Conference of the European Chapter of the Association for Computational Linguistics Conference (EACL), Apr 2003, Budapest, Hungary, pp107-110.

Curriculum Vitae