Cardiovascular Research Institute

Menu

Research Scientist

Dr Wong Lee Lee

Research Assistant Professor
Cardiovascular Research Institute
NUS YLL School of Medicine

Qualifications: 
PhD (NUS, Singapore)

BIO

Introduction:
Lee Lee is a Research Assistant Professor under the mentorship of Prof Arthur Mark Richards at Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore. Her research interest lies in biomarker applications in disease models that allow her to contribute in clinical research to help patients with heart disease. Notable achievements include the discovery study of using circulating microRNA as diagnostic biomarkers in heart failure.

GROUP MEMBERS

Azizah Binti Fadzil
Azizah Binti Fadzil

RESEARCH AREAS

  • Biomarker discovery and application in disease models

SELECTED PUBLICATIONS

  1. Chen Y.T., Wong L.L., Liew O.W., Richards AM. Heart Failure with Reduced Ejection Fraction (HFrEF) and Preserved Ejection Fraction (HFpEF): The Diagnostic Value of Circulating MicroRNAs. Cells 2019 Dec 16;8(12):1651. 
  2. Wong L. L., Saw E.L., Lim J.Y., Zhou Y., Richards A.M., Wang P. MicroRNA Let-7d-3p contributes to cardiac protection via targeting HMGA2. Int J. Mol. Sci. 2019 Mar 27;20(7). pii: E1522. 
  3. Wong L. L., Zou R., Zhou L., Lim J. Y., Phua D. C. Y., Liu C., Chong J. P. C., Ng J. Y. X., Liew O.W., Chang S.P., Chen Y., Chan M.M.Y., Yeo D.P.S., Ng T.P., Ling L.H., Sim D., Leong G.K.T., Ong H.Y., Jauferally F., Wong R., Chai P., Low A.F., Lund M., Devlin G., Troughton R., Cameron V.A., Doughty R.N., Lam C.C.P., Too H.P., Richards A.M. Combining circulating microRNA and NT-proBNP to detect and categorize heart failure subtype. Journal of the American College of Cardiology 2019 Mar 26;73(11):1300-1313. 
  4. Wang J., Tong K.S., Wong L.L., Liew OW, Raghuram D, Richards AM, Chen YT. MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells. Sci Rep. 2018 May 4;8(1):7055. 
  5. Wong L.L., Richards A.M. Harnessing the power of microRNAs as prognostic biomarkers in acute heart failure. Eur J Heart Fail. 2018 Jan;20(1):97-99. 
  6. Wong L.L., Rademaker MT, Saw EL, Lew KS, Ellmers LJ, Charles CJ, Richards AM, Wang P. Identification of novel microRNAs in the sheep heart and their regulation in heart failure. Sci Rep. 2017 Aug 15;7(1):8250. 
  7. Chen Y.T., Wang J., Tong K.S., Wong L.L., Liew O.W., Richards A.M. The Association of Heart Failure-related microRNAs with Neurohormonal Signaling. Biochimica et Biophysica Acta. 2017 Aug;1863(8):2031-2040. 
  8. Wong L.L., Wang J., Liew O.W., Richards A.M., Chen Y.T. MicroRNA and Heart Failure. Int J. Mol. Sci. 2016, 174(4), 502.
  9. Wong L.L., Wee S.Y., Lim J.Y., Ng Y.X., Chong P.C., Liew O.W., Lilyanna S., Martinez E.C., Ackers-Johnson A.A., Vardy L.A., Armugam A., Jeyaseelam K., Ng T.P., Lam S.P., Foo S.Y., Richards A.M. and Chen Y.T. NPR3 is negatively regulated by microRNA-100. Journal of Molecular and Cellular Cardiology. 2015 May; 82:13-21. 
  10. Wong L.L., Armugam A., Sepramaniam S., Dwi Setyowati K., Lim K.Y J., Lim J.Y., Chong P.C., Ng Y.X., Chen Y.T., Chan M.Y., Chen Z., Yeo P.S., Ng T.P., Ling L.H., Sim D., Leong K.T., Ong H.Y., Jauferally F., Wong R., Chai P., Low A.F., Lam S.P., Jeyaseelam K., Richards A.M. Circulating microRNAs in whole blood as candidate markers in heart failure with reduced and preserved left ventricular ejection fraction.  European Journal of Heart Failure. 2015 Apr; 17(4):393-404. 
Back to Top