Clinical Scientists
Associate Professor Mark Y. Chan
Deputy Director, Cardiovascular Research Institute (CVRI), NUHS
Deputy Executive Director, National University Heart Centre Singapore
Senior Consultant, National University Heart Centre Singapore
Deputy Director, NUS Cardiovascular Disease Translational Research Programme
Assoc Professor of Medicine, NUS Yong Loo Lin School of Medicine
Editorial board member of the American Heart Journal
Deputy editor of the Asean Heart Journal
Member, Domain C DSRB
Qualifications:
MD (SG), MBBS (SG), MRCP (UK), MHS (Duke), PHD (UL)
BIO
Introduction:
Dr Mark Chan, MBBS, PhD, is an Associate Professor at the Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore (NUS) and Senior Consultant at the Department of Cardiology, National University Heart Centre, Singapore.
He is deputy director of the Cardiovascular Disease Translational Research Program, NUS, and supervises translational research and clinical trials of acute myocardial infarction at the Cardiovascular Research Institute, NUS. He leads the post-myocardial infarction clinic at the National University Heart Centre, Singapore and the national Acute Myocardial Infarction: allied Health-Oriented, Patient-centred and technology-Enabled (AMI-HOPE) program with Singhealth and NHG colleagues. In 2019, he received the National Medical Research Council Clinician Scientist Senior Investigator Award. He is overall PI of the 3-country randomized controlled trial of an anti-inflammatory small-molecule inhibitor to treat atherosclerosis in patients with AMI (PASSIvation of Vulnerable plaques with AZD5718 in acuTE coronary syndrome – the PASSIVATE trial) supported by a 10 million USD externally-sponsored from Astra-Zeneca.
GROUP MEMBERS
RESEARCH AREAS
Thrombosis and antithrombotic therapy, Biologics in cardiovascular drug discovery, Biomarker discovery in acute coronary syndrome, Outcomes and systems of care in acute coronary syndrome, Innovative clinical trials
Google Scholar
SELECTED PUBLICATIONS
- Wesley Yeung, Ching-Hui Sia, Tom Pollard, Aloysius Sheng-Ting Leow, Benjamin Yong-Qiang Tan, Rajinderdeep Kaur, Tiong-Cheng Yeo, Edgar Lik-Wui Tay, Leonard Leong-Litt Yeo, Mark Yan-Yee Chan, Joshua Ping-Yun Loh. Predicting mortality, thrombus recurrence and persistence in patients with post-acute myocardial infarction left ventricular thrombus ion. J Thromb Thrombolysis. 2021 Jan 2. doi: 10.1007/s11239-020-02368-1. Online ahead of print.
- Mark Y Chan, Karen W L Koh, Sock-Cheng Poh, Stephanie Marchesseau, Devinder Singh, Yiying Han, Faclin Ng, Eleanor Lim , Joseph F Prabath, Chi-Hang Lee, Hui-Wen Sim, Ruth Chen, Leonardo Carvalho, Sock-Hwee Tan, Joshua P Y Loh , Jack W C Tan, Karishma Kuwelker, R M Amanullah, Chee-Tang Chin, James W L Yip, Choy-Yee Lee, Juvena Gan , Chew-Yong Lo , Hee-Hwa Ho, Derek J Hausenloy, Bee-Choo Tai, A Mark Richards , IMMACULATE Investigators. Remote Postdischarge Treatment of Patients With Acute Myocardial Infarction by Allied Health Care Practitioners vs Standard Care: The IMMACULATE Randomized Clinical Trial. JAMA Cardiol. 2020 Dec 30;e206721. doi: 10.1001/jamacardio.2020.6721. Online ahead of print.
- Sim HW, Zheng H, Richards AM, Chen RW, Sahlen A, Yeo KK, Tan JW, Chua T, Tan HC, Yeo TC, Ho HH, Liew BW, Foo LL, Lee CH, Hausenloy DJ, Chan MY. Beta-blockers and renin-angiotensin system inhibitors in acute myocardial infarction managed with inhospital coronary revascularization. Sci Rep. 2020 Sep 16;10(1):15184. doi: 10.1038/s41598-020-72232-y.
- Chan MY, Efthymios M, Tan SH, Pickering JW, Troughton R, Pemberton C, Ho HH, Prabath JF, Drum CL, Ling LH, Soo WM, Chai SC, Fong A, Oon YY, Loh JP, Lee CH, Foo RSY, Ackers-Johnson MA, Pilbrow A, Richards AM. Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics. Circulation. 2020 Oct 13;142(15):1408-1421. doi: 10.1161/CIRCULATIONAHA.119.045158. Epub 2020 Sep 4.
- Yip C, Seneviratna A, Tan SH, Khaing T, Chan SP, Loh J, Lee CH, Low AF, Drum CL, Poh SC, Gibson CM, Ohman EM, Richards AM, Chan MY. Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. J Thromb Thrombolysis. 2020 Aug;50(2):421-429. doi: 10.1007/s11239-020-02066-y.
- Leow AS, Sia CH, Tan BY, Kaur R, Yeo TC, Chan MY, Tay EL, Seet RC, Loh JP, Yeo LL. Characterisation of acute ischemic stroke in patients with left ventricular thrombi after myocardial infarction. J Thromb Thrombolysis. 2019 Jul;48(1):158-166. doi: 10.1007/s11239-019-01829-6.
- Leow AS, Sia CH, Tan BY, Chan MY, Loh JP. Long-Term Outcomes and Recurrence of Left Ventricular Thrombus After Anticoagulation. J Am Coll Cardiol. 2020 Jul 28;76(4):484-486. doi: 10.1016/j.jacc.2020.05.064.
- Paradies V, Zheng H, Chan MHH, Chan MYY, Foo DC, Lee CW, Lim ST, Tan HC, Tan JWC, Tong KL, Wong AS, Wong PE, Yeo KK, Foo LL, Chua TS, Koh TH, Bulluck H, Hausenloy DJ. Impact of time of onset of symptom of ST-segment elevation myocardial infarction on 1-year rehospitalization for heart failure and mortality. Am Heart J. 2020 Jun;224:1-9. doi: 10.1016/j.ahj.2020.03.011. Epub 2020 Mar 19.
- Sia CH, Zheng H, Ho AF, Bulluck H, Chong J, Foo D, Foo LL, Lim PZY, Liew BW, Tan HC, Yeo TC, Chua TSJ, Chan MY, Hausenloy DJ.The Lipid Paradox is present in ST-elevation but not in non-ST-elevation myocardial infarction patients: Insights from the Singapore Myocardial Infarction Registry. Sci Rep. 2020 Apr 22;10(1):6799. doi: 10.1038/s41598-020-63825-8.
- Leow AS, Sia CH, Tan BY, Chan MY, Loh JP. Characterisation of patients with acute myocardial infarction complicated by left ventricular thrombus. Eur J Intern Med. 2020 Apr;74:110-112. doi: 10.1016/j.ejim.2020.01.003. Epub 2020 Jan 16.
MOH-000280-00: “PASSIvation of Vulnerable plaques with AZD5718 in acuTE coronary syndrome (PASSIVATE)” ($1,750,000) – 01/09/2019 – 30/08/2024
NMRC/CIRG/1478/2017: “Uncoupling Thrombosis and Haemostasis in Patients Needing Combination Antiplatelet and Anticoagulant Therapy ($1,446,278.00) – 25/01/2018 – 31/01/2021
Young Investigator’s Award (clinical science and overall winner) 1st prize Singapore Cardiac Society 17th Annual Scientific Meeting awarded by the Singapore Cardiac Society
Ralph Snyderman Award 2007 for promising young investigators awarded by ex-chancellor Duke School of Medicine
Medical Research Fellowship award 2006-2008 awarded by NMRC, Singapore
Health Manpower Development Programme Fellowship award 2008-2009 awarded by Ministry of Health, Singapore
Young Investigator’s Award (clinical science & overall winner) 3rd prize Singapore Cardiac Society 21PthP Annual Scientific Meeting by Singapore Cardiac Society
Japan Society of Thrombosis and Haemostasis Asian-Pacific Scholarship 2011 for presentation entitled “Differential Prevalence and Pharmacodynamic Significance of CYP2C19 Polymorphisms in a Multiethnic Asian Cohort”
National Medical Research Council Clinician Scientist Award 2011
National Medical Research Council Clinician Scientist Award 2015
National Medical Research Council Senior Clinician Scientist Award 2019