Clinical Scientists
![](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/edited-Chester-Drum.jpeg)
Assistant Professor Chester Drum
National University of Singapore, Assistant Prof.
National University Hospital, Consultant
Faculty, Department of Surgery
Faculty, Department of Biochemistry
Faculty, N.1 institute for Health Informatics
Associate Faculty, NUHS Research Residency Program [RRP]
Faculty, Graduate School for Integrative Sciences & Engineering Scholarship (NGSS)
Ph.D. (Neurobiology), University of Chicago
M.D., University of Chicago, Pritzker School of Medicine
B.A., University of Chicago
BIO
Chester Drum, M.D. Ph.D., is a consultant cardiologist at the National University Hospital and an Asst. Prof. at the National University of Singapore. He is a Singapore permanent resident and currently maintains both internal medicine and cardiology board certifications in the US and Singapore. Dr. Drum received an M.D. and Ph.D. from the University of Chicago. He was trained in medicine at the University of California, San Diego and as a cardiologist at Brigham and Women’s Hospital (Harvard Medical School), in Boston. He then moved to Massachusetts Institute of Technology (MIT) where he received the Burroughs Wellcome Career Award for Medical Scientists. In Singapore, he has been a recipient of a Clinician Scientist Award from the NMRC, funding from the A*STAR, BMRC and multiple innovation awards from the Singapore MIT Alliance for Research and Technology (SMART).
At National University Hospital in Singapore, Dr. Drum has continued his passion for combining clinical care with technological innovation to create value for patients. Drawing on his over 20 years of clinical experience in managed care, private, public and academic healthcare settings in the US and Asia, Dr. Drum’s current research combines the use of advanced analytics and clinical phenotyping to create novel ways of predicting risk and benefit for patient care. Dr. Drum has multiple patents and oversees a large research facility and analytics unit at NUH. His current efforts are focused on the implementation of cost-beneficial precision medicine within NUH through the combination of information technology and advanced risk prediction models. Dr. Drum is a member of the Clinical Adoption Working Group (CAWG) for Precision Medicine at the Ministry of Health and a member of the International Standards Organization (Cat A Liaison – ISO 215, Health Informatics)in addition to being an expert advisor to the World Health Organization. Dr. Drum’s publications include contributions to the journals Nature, Nature Communications, Journal of the American Heart Association, PNAS and Small in addition to featured editorial content in Science Translational Medicine.
GROUP MEMBERS
![Wu Lik Hang](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-103-150x150.png)
![Eugene Goh](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-104-150x150.png)
![Xu Lik Lam](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-105-150x150.png)
![Samira Sadeghi](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-106-150x150.png)
![Racell Solis](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-107-150x150.png)
![Siddhesh Vaidya](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-108-150x150.png)
![Desai Malan Manish (Priya)](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-109-150x150.png)
![Dr Ng Mei Li](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-110-150x150.png)
![Dr. Girish Vallerinteavide Mavelli](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-111-150x150.png)
![Dr Leroy Pakkiri](https://medicine.nus.edu.sg/cvri/wp-content/uploads/sites/24/2022/06/blank-profile-picture-973460_640-112-150x150.png)
RESEARCH AREAS
Google Scholar
SELECTED PUBLICATIONS
- Brandon N S Ooi, Raechell Raechell, Ariel F Ying, Yong Zher Koh, Yu Jin, Sherman W L Yee, Justin H S Lee, Samuel S Chong, Jack W C Tan, Jianjun Liu, Caroline G Lee, Chester L Drum, Robust performance of potentially functional SNPs in machine learning models for the prediction of atorvastatin-induced myalgia, Frontiers in Pharmacology, (in press)
- James W Dear, Mei Li Ng, D Nicholas Bateman, Pakkiri Leroy, Sivappiragasam, Hyungwon Choi, Bing Jie Khoo, Baharudin Ibrahim, Chester Lee Drum, A Metabolomic Analysis of Thiol Response In Standard And Modified N-Acetyl Cysteine Treatment Regimens, Clinical and Translational Science (in press) (IF = 4)
- Jie Gao, Kwee Hiang Jackson Low, Yang Chen, E. Shyong Tai, Tai-Shung Chung and Chester Lee Drum, High recovery, point-of-collection plasma separation from blood using electrospun polyacrylonitrile (PAN) membranes, AIChE Journal. 2020 Oct 02. https://doi.org/10.1002/aic.17088 (IF = 3.5)
- Chan MY, Efthymios M, Tan SH, Pickering JW, Troughton R, Pemberton C, Ho HH, Prabath JF, Drum CL, Ling LH, Soo WM, Chai SC, Fong A, Oon YY, Loh JP, Lee CH, Foo RSY, Ackers-Johnson MA, Pilbrow A, Richards AM. Prioritizing Candidates of Post-Myocardial Infarction Heart Failure Using Plasma Proteomics and Single-Cell Transcriptomics, Circulation. 2020 Sep 4. doi: 10.1161/CIRCULATIONAHA.119.045158 (IF = 23.6)
- Landreh M, Sahin C, Gault J, Sadeghi S, Drum CL, Uzdavinys P, Drew D, Allison TM, Degiacomi MT, Marklund EG, Predicting the shapes of protein complexes through collision cross section measurements and database searches. Anal. Chem. July 13, 2020, https://doi.org/10.1021/acs.analchem.0c01940 (IF = 6.3)
- Tai YK, Ng, C, Purnamawati K, et al., Magnetic Fields Modulate Metabolism and Gut Microbiome in Correlation With Pgc-1α Expression: Follow-up to an in Vitro Magnetic Mitohormetic Study. FASEB J. 2020 PMID: 32627872, DOI: 10.1096/fj.201903005RR (IF = 5)
- Yee WL, Drum CL, Increasing Complexity to Simplify Clinical Care: High Resolution Mass Spectrometry as an Enabler of AI Guided Clinical and Therapeutic Monitoring. Adv. Therapeutics. 2020 Mar. doi.org/10.1002/adtp.201900163
- Sadeghi S, Lee WK, Kong SN, Shetty A, Drum CL. Oral administration of protein nanoparticles: An emerging route to disease treatment. Pharmacol Res. 2020 Feb 22:104685. doi: 10.1016/j.phrs.2020.104685. (IF=5.6)
- Yip C, Seneviratna A, Tan SH, Khaing T, Chan SP, Loh J, Lee CH, Low AF, Drum CL, Poh SC, Gibson CM, Ohman EM, Richards AM, Chan MY. Patients with acute and chronic coronary syndromes have elevated long-term thrombin generation. J Thromb Thrombolysis. 2020 Feb 19. doi: 10.1007/s11239-020-02066-y. (IF=2.9)
- Krishnamurthy S, Muthukumaran P, Jayakumar MKG, Lisse D, Masurkar ND, Xu C, Chan JM, Drum, C.L. Surface protein engineering increases the circulation time of a cell membrane-based nanotherapeutic. Nanomedicine. 2019 Jun;18:169-178. doi: 10.1016/j.nano.2019.02.024. (IF=6.5)
Funding Support: (only grants with CLD as senior PI are listed):
- Strategic Positioning Fund (SPF), A Star BMRC
- Clinician Scientist (Senior Investigator) Award, NMRC
- Innovation Award, SMART
- Execution Award, SMART
- Ignition Award, SMART
- Enterprise Technology Acceleration Programme (TAP) Grant Award, NUS ILO
- Innovation to Develop (12D) Award, NHIC
- Talent Development Award, RSF NMRC
- Advanced Manufacturing and Engineering (AME), A Star–AME IRG
Patents:
- Drum CL, et al, Dry Blood Spot Tests Development For Health Assessment In Singapore – Implementation Of New Material For Regulatory Approval: PCT No. 10201910574R
- GAO Jie (NUS), 2. CHUNG Tai-Shung (NUS), 3. LOW Kwee Hiang Jackson (NUS), 4. DRUM Chester Lee (NUS), 5. TAI E Shyong (NUS). International Patent Application No. PCT/SG2020/050650: A Multi-Layered Membrane And A Method Of Preparing The Same
- Drum C.L., Desphande S, Mazurkar N, and National University of Singapore (NUS) US Provisional Patent Application No. 62/405,613: Compositions And Methods For Protein Expression And Delivery
- Drum C.L., and National University of Singapore. (NUS) US Provisional Patent Application No. 62/072,727: Light-Activated Two-Component Protein Binding Matrix