Research Scientist
Dr Koh Cho Yeow
Research Director, Cardiovascular Disease Translation Research Programme, NUS Yong Loo Lin School of Medicine
Qualifications:
PhD (NUS, SG), BSc, Pharm (NUS, SG)
BIO
Introduction:
My research mainly focuses on the discovery and characterization of novel proteins and peptides (toxins) from natural sources such as haematophagous and venomous animals, with an emphasis on the development of therapeutics and medical technologies, especially in the field of cardiovascular and neglected tropical diseases.
GROUP MEMBERS
RESEARCH AREAS
- Structure-function relationships
- Drug/probe discovery
- Venom
- Salivary proteins
- X-ray crystallography
- Rademaker MT, Scott NJA, Koh CY, Kini RM, Richards AM. Natriuretic peptide analogues with distinct vasodilatory or renal activity: integrated effects in health and experimental heart failure. Cardiovasc Res. 2021 Jan 21;117(2):508-519.
- Kini RM, Koh CY. Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases. Biochem Pharmacol. 2020 Nov;181:114105.
- Latinović Z, Leonardi A, Koh CY, Kini RM, Trampuš Bakija A, Pungerčar J, Križaj I. The Procoagulant Snake Venom Serine Protease Potentially Having a Dual, Blood Coagulation Factor V and X-Activating Activity. Toxins (Basel). 2020 May 29;12(6).
- Koh CY, Bendre R, Kini RM. Repurposed drug to the rescue of snakebite victims. Sci Transl Med. 2020 May 6;12(542).
- Modahl CM, Brahma RK, Koh CY, Shioi N, Kini RM. Omics Technologies for Profiling Toxin Diversity and Evolution in Snake Venom: Impacts on the Discovery of Therapeutic and Diagnostic Agents. Annu Rev Anim Biosci. 2020 Feb 15;8:91-116.
- Raskar T, Koh CY, Niebling S, Kini RM, Hosur MV. X-ray crystallographic analysis of time-dependent binding of guanidine hydrochloride to HEWL: First steps during protein unfolding. Int J Biol Macromol. 2019 Feb 1;122:903-913.
- Latinović Z, Leonardi A, Kovačič L, Koh CY, Šribar J, Bakija AT, Venkateswarlu D, Kini RM, Križaj I. The First Intrinsic Tenase Complex Inhibitor with Serine Protease Structure Offers a New Perspective in Anticoagulant Therapy. Thromb Haemost. 2018 Oct;118(10):1713-1728.
- Koh CY, Kini RM. Exogenous Factors from Venomous and Hematophagous Animals in Drugs and Diagnostic Developments for Cardiovascular and Neurovascular Diseases. Cardiovasc Hematol Disord Drug Targets. 2019;19(2):90-94.
- Koh CY, Modahl CM, Kulkarni N, Kini RM. Toxins Are an Excellent Source of Therapeutic Agents against Cardiovascular Diseases. Semin Thromb Hemost. 2018 Oct;44(7):691-706.
NMRC OF-YIRG NMRC/OFYIRG/0026/2016 SGD 250,000
Editorial board: Biomedicines
Peer reviewer: Science Translational Medicine, Journal of Thrombosis and Haemostasis, Biochemical Pharmacology, Toxins, Scientific Reports, International Journal of Molecular Sciences, The International Journal of Biochemistry & Cell Biology, Bioorganic Chemistry and others
Young Investigator Award, The 9th Congress of Asia-Pacific Society on Thrombosis and Hemostasis, Taipei, Taiwan (2016)
Young Investigator Award, The 30th Congress of Japanese Society on Thrombosis and Hemostasis, Shima City, Japan (2007)