{"id":1589,"date":"2025-02-28T10:05:01","date_gmt":"2025-02-28T02:05:01","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/circ\/?p=1589"},"modified":"2026-01-07T10:33:17","modified_gmt":"2026-01-07T02:33:17","slug":"gmp-validation-of-actinium-255-radiopharmaceutical","status":"publish","type":"post","link":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/","title":{"rendered":"GMP validation of actinium-255 radiopharmaceutical"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1589\" class=\"elementor elementor-1589\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e38a57d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e38a57d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b8a9979\" data-id=\"b8a9979\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-22c233b elementor-widget elementor-widget-text-editor\" data-id=\"22c233b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-family: georgia, palatino, serif; font-size: 12pt;\">CIRC collaboratively developed and GMP validated a novel Ac 225 based radiopharmaceutical, representing a significant scientific and translational milestone. In parallel, CIRC supported the sponsor with regulatory activities, including contributions to the FDA filing process. The radiopharmaceutical demonstrated high radiochemical purity, stability, and reproducibility, thereby establishing a robust and reliable manufacturing process for alpha emitter therapeutics. This work also resulted in a peer reviewed publication, co authored by CIRC, entitled <i>Development of [225Ac]Ac LNC1011 for targeted alpha radionuclide therapy of prostate cancer<\/i> (European Journal of Nuclear Medicine and Molecular Imaging, 2025). Collectively, these achievements position the institution to support external translational and clinical partners, strengthen the national alpha therapy ecosystem, and enhance CIRC\u2019s attractiveness for future research, development, and funding opportunities.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>CIRC collaboratively developed and GMP validated a novel Ac 225 based radiopharmaceutical, representing a significant scientific and translational milestone. In parallel, CIRC supported the sponsor with regulatory activities, including contributions to the FDA filing process. The radiopharmaceutical demonstrated high radiochemical purity, stability, and reproducibility, thereby establishing a robust and reliable manufacturing process for alpha emitter [&hellip;]<\/p>\n","protected":false},"author":9466,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1589","post","type-post","status-publish","format-standard","hentry","category-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>GMP validation of actinium-255 radiopharmaceutical - NUS CIRC<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GMP validation of actinium-255 radiopharmaceutical - NUS CIRC\" \/>\n<meta property=\"og:description\" content=\"CIRC collaboratively developed and GMP validated a novel Ac 225 based radiopharmaceutical, representing a significant scientific and translational milestone. In parallel, CIRC supported the sponsor with regulatory activities, including contributions to the FDA filing process. The radiopharmaceutical demonstrated high radiochemical purity, stability, and reproducibility, thereby establishing a robust and reliable manufacturing process for alpha emitter [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/\" \/>\n<meta property=\"og:site_name\" content=\"NUS CIRC\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-28T02:05:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-07T02:33:17+00:00\" \/>\n<meta name=\"author\" content=\"Ern Ming, Lemuel\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ern Ming, Lemuel\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/\",\"url\":\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/\",\"name\":\"GMP validation of actinium-255 radiopharmaceutical - NUS CIRC\",\"isPartOf\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/#website\"},\"datePublished\":\"2025-02-28T02:05:01+00:00\",\"dateModified\":\"2026-01-07T02:33:17+00:00\",\"author\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/54bd13413bd18cb554661edbd286ce03\"},\"breadcrumb\":{\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medicine.nus.edu.sg\/circ\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"GMP validation of actinium-255 radiopharmaceutical\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/#website\",\"url\":\"https:\/\/medicine.nus.edu.sg\/circ\/\",\"name\":\"NUS CIRC\",\"description\":\"Clinical Imaging Research Centre\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medicine.nus.edu.sg\/circ\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/54bd13413bd18cb554661edbd286ce03\",\"name\":\"Ern Ming, Lemuel\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/96ef6130dcaeb04ccd288b5f49f7bd3b9cd3b1a003dfc3fa1802722c75cff200?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/96ef6130dcaeb04ccd288b5f49f7bd3b9cd3b1a003dfc3fa1802722c75cff200?s=96&d=mm&r=g\",\"caption\":\"Ern Ming, Lemuel\"},\"url\":\"https:\/\/medicine.nus.edu.sg\/circ\/author\/lemuel\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"GMP validation of actinium-255 radiopharmaceutical - NUS CIRC","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/","og_locale":"en_US","og_type":"article","og_title":"GMP validation of actinium-255 radiopharmaceutical - NUS CIRC","og_description":"CIRC collaboratively developed and GMP validated a novel Ac 225 based radiopharmaceutical, representing a significant scientific and translational milestone. In parallel, CIRC supported the sponsor with regulatory activities, including contributions to the FDA filing process. The radiopharmaceutical demonstrated high radiochemical purity, stability, and reproducibility, thereby establishing a robust and reliable manufacturing process for alpha emitter [&hellip;]","og_url":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/","og_site_name":"NUS CIRC","article_published_time":"2025-02-28T02:05:01+00:00","article_modified_time":"2026-01-07T02:33:17+00:00","author":"Ern Ming, Lemuel","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Ern Ming, Lemuel","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/","url":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/","name":"GMP validation of actinium-255 radiopharmaceutical - NUS CIRC","isPartOf":{"@id":"https:\/\/medicine.nus.edu.sg\/circ\/#website"},"datePublished":"2025-02-28T02:05:01+00:00","dateModified":"2026-01-07T02:33:17+00:00","author":{"@id":"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/54bd13413bd18cb554661edbd286ce03"},"breadcrumb":{"@id":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medicine.nus.edu.sg\/circ\/gmp-validation-of-actinium-255-radiopharmaceutical\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medicine.nus.edu.sg\/circ\/"},{"@type":"ListItem","position":2,"name":"GMP validation of actinium-255 radiopharmaceutical"}]},{"@type":"WebSite","@id":"https:\/\/medicine.nus.edu.sg\/circ\/#website","url":"https:\/\/medicine.nus.edu.sg\/circ\/","name":"NUS CIRC","description":"Clinical Imaging Research Centre","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicine.nus.edu.sg\/circ\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/54bd13413bd18cb554661edbd286ce03","name":"Ern Ming, Lemuel","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicine.nus.edu.sg\/circ\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/96ef6130dcaeb04ccd288b5f49f7bd3b9cd3b1a003dfc3fa1802722c75cff200?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/96ef6130dcaeb04ccd288b5f49f7bd3b9cd3b1a003dfc3fa1802722c75cff200?s=96&d=mm&r=g","caption":"Ern Ming, Lemuel"},"url":"https:\/\/medicine.nus.edu.sg\/circ\/author\/lemuel\/"}]}},"_links":{"self":[{"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/posts\/1589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/users\/9466"}],"replies":[{"embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/comments?post=1589"}],"version-history":[{"count":4,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/posts\/1589\/revisions"}],"predecessor-version":[{"id":1593,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/posts\/1589\/revisions\/1593"}],"wp:attachment":[{"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/media?parent=1589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/categories?post=1589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicine.nus.edu.sg\/circ\/wp-json\/wp\/v2\/tags?post=1589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}