CIRC is a National Research Platform that supports and facilitates nuclear imaging research in Singapore. Parties interested in the GMP compliant manufacture of novel or established radiopharmaceuticals can contact CIRC directly at circenquiries@nus.edu.sg<\/a><\/p>\nProduct List<\/h3>\n
Application<\/strong><\/td>\n| Radionuclide<\/strong><\/td>\n | Radiopharmaceutical \/ Tracer<\/b><\/td>\n | Use<\/b><\/td>\n<\/tr>\n | Diagnostic<\/td>\n | \u00b9\u00b9C<\/td>\n | [\u00b9\u00b9C]Acetate<\/td>\n | Traces oxidative metabolism as an alternative substrate to glucose; useful in oncology and cardiology, including assessment of myocardial oxygen consumption.<\/td>\n<\/tr>\n | [\u00b9\u00b9C]MTO (Metomidate)<\/td>\n | Selectively binds adrenal cortex enzymes; supports characterisation and lateralisation of adrenal lesions in primary hyperaldosteronism.<\/td>\n<\/tr>\n | [\u00b9\u00b9C]MSTAT (Martinostat)<\/td>\n | HDAC inhibitor analogue enabling in vivo imaging of histone deacetylase activity in cardiac disease, oncology and neurodegenerative or psychiatric disorders.<\/td>\n<\/tr>\n | <\/td>\n | \u00a0<\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | Diagnostic<\/td>\n | \u00b9\u2078F<\/td>\n | [\u00b9\u2078F]NAV-4694 (Flutafuranol)<\/td>\n | High-affinity amyloid-\u00df tracer for sensitive detection of cerebral amyloid deposition in Alzheimer\u2019s disease research and clinical evaluation)<\/td>\n<\/tr>\n | [\u00b9\u2078F]MK-6240 (Florquinitau)<\/td>\n | Next-generation tau tracer targeting neurofibrillary tangles for detailed mapping of tau pathology in Alzheimer\u2019s disease.<\/td>\n<\/tr>\n | [\u00b9\u2078F]FEPPA<\/td>\n | TSPO ligand for imaging microglial and macrophage activation in neuroinflammation, systemic inflammatory conditions and selected oncology applications.<\/td>\n<\/tr>\n | <\/td>\n | \u00a0<\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | Diagnostic<\/td>\n | \u2076\u2078Ga<\/td>\n | [\u2076\u2078Ga]Ga-PSMA-11<\/td>\n | Targets PSMA for sensitive detection, staging and recurrence assessment of prostate cancer and for selecting patients for PSMA-directed therapy.<\/td>\n<\/tr>\n | [\u2076\u2078Ga]Ga-NOTA-EB<\/td>\n | Evans Blue derivative for visualising blood volume, vascular permeability and lymphatic drainage.<\/td>\n<\/tr>\n | [\u2076\u2078Ga]Ga-FAPI-46<\/td>\n | Binds fibroblast activation protein, enabling imaging of tumour stroma and cancer-associated fibroblasts across a broad range of malignancies.<\/td>\n<\/tr>\n | [\u2076\u2078Ga]Ga-LNC1007<\/td>\n | Dual-target heterodimer binding both FAP and integrin \u03b1v\u03b23 to characterise tumour cells and their microenvironment simultaneously.<\/td>\n<\/tr>\n | [\u2076\u2078Ga]Ga-DOTA-TATE<\/td>\n | Somatostatin receptor subtype 2 tracer for imaging neuroendocrine tumours.<\/td>\n<\/tr>\n | [\u2076\u2078Ga]Ga-CPCR4 (PentixaFor)<\/td>\n | CXCR4-targeting tracer for visualisation of chemokine receptor expression in oncology, inflammation and immune-related diseases.<\/td>\n<\/tr>\n | <\/td>\n | \u00a0<\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | Therapy<\/td>\n | \u00b9\u2077\u2077Lu<\/td>\n | [\u00b9\u2077\u2077Lu]Lu-LNC1003<\/td>\n | PSMA-targeting radiotherapeutic (Evans Blue modified) for treatment of PSMA-expressing prostate cancer.<\/td>\n<\/tr>\n | [\u00b9\u2077\u2077Lu]Lu-LNC1004<\/td>\n | FAP-directed therapeutic agent designed for tumours with high fibroblast activation protein expression.<\/td>\n<\/tr>\n | [\u00b9\u2077\u2077Lu]Lu-LNC1010<\/td>\n | Somatostatin receptor 2\u2013targeted radioligand for therapy of SSTR2-expressing tumours.<\/td>\n<\/tr>\n | [\u00b9\u2077\u2077Lu]Lu-LNC1011<\/td>\n | PSMA-targeting radiotherapeutic under investigation for metastatic castration-resistant prostate cancer.<\/td>\n<\/tr>\n | [\u00b9\u2077\u2077Lu]Lu-DOTA EB-TATE<\/td>\n | Evans Blue\u2013modified SSTR2 radiotherapeutic for enhanced retention and treatment of neuroendocrine tumours.<\/td>\n<\/tr>\n | <\/td>\n | \u00a0<\/td>\n | <\/td>\n | <\/td>\n<\/tr>\n | Therapy<\/td>\n | \u00b2\u00b2\u2075Ac<\/td>\n | [\u00b2\u00b2\u2075Ac]Ac-LNC1011<\/td>\n | Alpha-emitting PSMA radiotherapeutic candidate for resistant or advanced PSMA-positive prostate cancer.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n | <\/p>\n","protected":false},"excerpt":{"rendered":" CIRC is a National Research Platform that supports and facilitates nuclear imaging research in Singapore. Parties interested in the GMP compliant manufacture of novel or established radiopharmaceuticals can contact CIRC directly at circenquiries@nus.edu.sg Product List Application Radionuclide Radiopharmaceutical \/ Tracer Use Diagnostic \u00b9\u00b9C [\u00b9\u00b9C]Acetate Traces oxidative metabolism as an alternative substrate to glucose; useful in […]<\/p>\n","protected":false},"author":8255,"featured_media":0,"parent":100,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"accordion.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1260","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n |