{"id":1232,"date":"2025-05-28T11:24:52","date_gmt":"2025-05-28T03:24:52","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/circ\/?page_id=1232"},"modified":"2026-01-06T16:14:09","modified_gmt":"2026-01-06T08:14:09","slug":"facilities-and-equipment-2","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/circ\/facilities\/radiochemistry\/facilities-and-equipment-2\/","title":{"rendered":"Facilities and Equipment"},"content":{"rendered":"

Facilities and Equipment<\/h1>\n

Radioisotope Production<\/h2>\n

At the core of our manufacturing facility is a 16.5MeV GE PETtrace 800 series cyclotron for the production of short lived radioisotopes. The accelerator is self-shielded and equipped with 6 separate target positions. The cyclotron supports dual beam operation, allowing CIRC infrastructure to operate efficiently and reliably under high-demand conditions.<\/p>\n

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Radiochemistry Research & Manufacturing<\/h2>\n

Our facility features two GMP-compliant cleanrooms dedicated to the synthesis and formulation of a wide range of radiopharmaceuticals. All product dispensing is performed aseptically in a sterile Grade A environment to ensure product quality and safety. Both cleanrooms are equipped with automatic synthesis modules to facilitate labelling with carbon-11, fluorine-18, gallium-68, lutetium-177 or actinium-225. Synthesis Modules include Scintomics GRP, iPhase MultiSyn, Trasis MiniAIO, GE Tracerlab FXN, GE Tracerlab FXC, Ora NEPTIS and iQS system.<\/p>\n

Quality Control Testing<\/h2>\n

A critical component of the CIRC infrastructure is our comprehensive Quality Control Laboratory, ensuring each product meets the highest standards of safety, purity and regulatory compliance. The laboratory is equipped with advanced instrumentation, including two HPLC systems, two Gas Chromatography units, dose calibrators, multi-channel analyzer, and other analytical tools to support rigorous in-process and final product testing<\/p>\n

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Blood Metabolite Analysis Laboratory<\/h2>\n

An analytical laboratory is adjacent to the PET Imaging suites, which includes a Perkin Elmer Wizard gamma counter, scales, centrifuges, and HPLC equipment for plasma sample analysis for unchanged radiotracer, enabling generation of input functions required for kinetic analysis and image quantification. A Swisstrace blood sampling system is also available at CIRC to allow for arterial input function analysis<\/p>\n\n\n\n
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Imaging Modalities<\/h2>\n

CIRC hosts two hybrid imaging scanners for Positron Emission Tomography studies. Firstly, the Siemens Biograph mMR combined PET\/MR imaging system, capable of simultaneous PET and MR acquisition. The mMR also has multi-nuclear capability for alternative MR-active nuclei including carbon-13, phosphorus-31 and sodium-23. The second PET scanner available at CIRC is a 128 slice Siemens Biograph mCT PET\/CT system.<\/p>\n\n\n\n
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Facilities and Equipment Radioisotope Production At the core of our manufacturing facility is a 16.5MeV GE PETtrace 800 series cyclotron for the production of short lived radioisotopes. The accelerator is self-shielded and equipped with 6 separate target positions. The cyclotron supports dual beam operation, allowing CIRC infrastructure to operate efficiently and reliably under high-demand conditions. 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