{"id":8807,"date":"2026-01-30T14:12:39","date_gmt":"2026-01-30T06:12:39","guid":{"rendered":"https:\/\/medicine.nus.edu.sg\/bch\/?page_id=8807"},"modified":"2026-07-02T11:20:33","modified_gmt":"2026-07-02T03:20:33","slug":"the-sorrentino-laboratory","status":"publish","type":"page","link":"https:\/\/medicine.nus.edu.sg\/bch\/the-sorrentino-laboratory\/","title":{"rendered":"The Sorrentino Laboratory"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"8807\" class=\"elementor elementor-8807\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f6fc40a elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"f6fc40a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29c240a\" data-id=\"29c240a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-86d4fd5 elementor-widget elementor-widget-image\" data-id=\"86d4fd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1983\" height=\"793\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page.png\" class=\"attachment-full size-full wp-image-9196\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page.png 1983w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page-300x120.png 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page-1024x409.png 1024w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page-768x307.png 768w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/06\/possible-cover-image-for-my-lab-page-1536x614.png 1536w\" sizes=\"(max-width: 1983px) 100vw, 1983px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f20d85 elementor-nav-menu--stretch elementor-nav-menu__align-justify elementor-hidden-mobile elementor-nav-menu--dropdown-tablet elementor-nav-menu__text-align-aside elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"0f20d85\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;full_width&quot;:&quot;stretch&quot;,&quot;layout&quot;:&quot;horizontal&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i class=\\&quot;fas fa-caret-down\\&quot; 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Publications<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-8835\"><a href=\"https:\/\/medicine.nus.edu.sg\/bch\/the-sorrentino-laboratory\/vsorrent-lab-gallery\/\" class=\"elementor-item\" tabindex=\"-1\">Lab Gallery<\/a><\/li>\n<li class=\"menu-item menu-item-type-custom menu-item-object-custom menu-item-8836\"><a href=\"https:\/\/medicine.nus.edu.sg\/bch\/vsorrent-contact-us\/\" class=\"elementor-item\" tabindex=\"-1\">Contact Us<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13e6268 elementor-widget elementor-widget-spacer\" data-id=\"13e6268\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1f42b3c elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"1f42b3c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-a7e1882\" data-id=\"a7e1882\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-4d80c0d\" data-id=\"4d80c0d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7e85a6e elementor-widget elementor-widget-text-editor\" data-id=\"7e85a6e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #ff9900;\">The Sorrentino Laboratory<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">The Sorrentino Laboratory is based in the Department of Biochemistry and in the <span style=\"color: #ff6600;\"><a href=\"https:\/\/coe.nuhs.edu.sg\/centre-for-healthy-longevity\/about-us\" style=\"color: #ff6600;\">Centre for Healthy Longevity (CHL)<\/a><\/span>, part of the Healthy Longevity Translational Research Programme (HLTRP) at the Yong Loo Lin School of Medicine, National University of Singapore. Led by <span style=\"color: #ff6600;\"><a href=\"https:\/\/medicine.nus.edu.sg\/bch\/faculty\/vincenzo-sorrentino\/\" style=\"color: #ff6600;\">Assistant Professor Vincenzo Sorrentino<\/a><\/span>, the lab investigates fundamental mechanisms that govern ageing and age-associated diseases, with a strong emphasis on identifying actionable targets to promote healthy longevity. Our work bridges basic molecular biology with translational and computational approaches to address the growing global burden of age-related decline.<\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-b64dcfd\" data-id=\"b64dcfd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a6da48f elementor-widget elementor-widget-image\" data-id=\"a6da48f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/processed-E36DDAEB-5FC8-4A83-8290-BA1E56AAA86A.jpeg\" class=\"attachment-large size-large wp-image-9084\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/processed-E36DDAEB-5FC8-4A83-8290-BA1E56AAA86A.jpeg 959w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/processed-E36DDAEB-5FC8-4A83-8290-BA1E56AAA86A-300x300.jpeg 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/processed-E36DDAEB-5FC8-4A83-8290-BA1E56AAA86A-150x150.jpeg 150w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/processed-E36DDAEB-5FC8-4A83-8290-BA1E56AAA86A-768x768.jpeg 768w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-753767f\" data-id=\"753767f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7798c01 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7798c01\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-a90f55f\" data-id=\"a90f55f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9dee2d3 elementor-widget elementor-widget-spacer\" data-id=\"9dee2d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b7d76e7 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b7d76e7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-0adc459\" data-id=\"0adc459\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-661e735\" data-id=\"661e735\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53cc533 elementor-widget elementor-widget-image\" data-id=\"53cc533\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"521\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-1024x834.png\" class=\"attachment-large size-large wp-image-9109\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-1024x834.png 1024w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-300x244.png 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-768x625.png 768w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-1536x1251.png 1536w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/Proteostat-2048x1667.png 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-8d58c7d\" data-id=\"8d58c7d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-40138b2 elementor-widget elementor-widget-text-editor\" data-id=\"40138b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #ff9900;\">What We Study<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">Our core scientific interest is to identify and mechanistically characterise molecular targets that regulate ageing and health span. The lab investigates how pathways involved in NAD\u207a metabolism, cellular energy homeostasis, stress responses, and protein quality control collectively contribute to cellular and organismal longevity. Using a combination of mechanistic studies, we examine how perturbations in these systems give rise to age-associated phenotypes, including metabolic dysfunction, neurodegeneration, and tissue decline.<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">The lab also makes use of computational biology and bioinformatics approaches to complement experimental work, aiding in hypothesis generation and exploratory analyses. We apply structure-based analyses, molecular docking, molecular dynamics simulations, and cheminformatics to support target prioritisation and small-molecule evaluation, particularly within NAD+-related and proteostasis-linked pathways. This integrative strategy allows the lab to connect <em>in silico<\/em> insights with mechanistic and functional validation in biological systems.<\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-7178a2b\" data-id=\"7178a2b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f1d5912 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"f1d5912\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-8d520c6\" data-id=\"8d520c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0b625a1 elementor-widget elementor-widget-spacer\" data-id=\"0b625a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a487fec elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"a487fec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-622fe12\" data-id=\"622fe12\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-2eb9a49\" data-id=\"2eb9a49\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6fcc854 elementor-widget elementor-widget-text-editor\" data-id=\"6fcc854\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #ff9900;\">Our Points of Interest<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">\u00a0\u2022\u00a0 Molecular targets and pathways that regulate ageing, healthspan, and age-associated disease<br \/>\u00a0\u2022\u00a0 NAD\u207a metabolism, cellular homeostasis, and stress response mechanisms studied across <em>in vitro, in vivo<\/em>, and <em>in silico<\/em> models<br \/>\u00a0\u2022\u00a0 Mechanistic and translational evaluation of longevity-associated molecules using integrated experimental and computational approaches<br \/><\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-44742ff\" data-id=\"44742ff\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-90da0f7 elementor-widget elementor-widget-image\" data-id=\"90da0f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"534\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-1024x854.jpg\" class=\"attachment-large size-large wp-image-9108\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-1024x854.jpg 1024w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-300x250.jpg 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-768x641.jpg 768w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-1536x1282.jpg 1536w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/khalishah_histology-2048x1709.jpg 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-8618024\" data-id=\"8618024\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7955dec elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7955dec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-2ba03c0\" data-id=\"2ba03c0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-551b28e elementor-widget elementor-widget-spacer\" data-id=\"551b28e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9a7ff71 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"9a7ff71\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-c0788ee\" data-id=\"c0788ee\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-6037468\" data-id=\"6037468\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a3cf31f elementor-widget elementor-widget-image\" data-id=\"a3cf31f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"283\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-1024x453.png\" class=\"attachment-large size-large wp-image-9106\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-1024x453.png 1024w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-300x133.png 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-768x339.png 768w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-1536x679.png 1536w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/C-elegans-2048x905.png 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-fe09658\" data-id=\"fe09658\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-743125f elementor-widget elementor-widget-text-editor\" data-id=\"743125f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #ff9900;\">Experimental Models and Translational Approach<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">The lab employs a diverse range of preclinical models, including <em>C. elegans<\/em>, mammalian cell systems, and <em>in vivo<\/em> rodent models to uncover conserved ageing mechanisms and validate computational predictions. By combining wet-lab experimentation with <em>in silico<\/em> modelling, we aim to identify robust biomarkers and therapeutic strategies that can be translated toward interventions for age-associated diseases.<\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-9dd14e6\" data-id=\"9dd14e6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0e44e60 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"0e44e60\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-178a663\" data-id=\"178a663\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-861a09c elementor-widget elementor-widget-spacer\" data-id=\"861a09c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-ab2154b elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"ab2154b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-ee79332\" data-id=\"ee79332\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-ebba604\" data-id=\"ebba604\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0d42b5e elementor-widget elementor-widget-text-editor\" data-id=\"0d42b5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><span style=\"color: #ff9900;\">Global Impact and Collaborative Research<\/span><\/h2><h2><span style=\"font-size: 12pt; color: #333399;\">The lab\u2019s innovative focus on mitochondrial biology, proteostasis, and computationally driven target discovery has gained international recognition. Sorrentino\u2019s selection to the EMBO Global Investigator Network reflects the lab\u2019s growing global footprint and commitment to collaborative, interdisciplinary research aimed at extending health span in ageing populations.<br \/><\/span><\/h2>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-a4a702f\" data-id=\"a4a702f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68bcaa9 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"68bcaa9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"640\" src=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508-1024x1024.jpg\" class=\"attachment-large size-large wp-image-9087\" alt=\"\" srcset=\"https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508-1024x1024.jpg 1024w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508-300x300.jpg 300w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508-150x150.jpg 150w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508-768x768.jpg 768w, https:\/\/medicine.nus.edu.sg\/bch\/wp-content\/uploads\/sites\/13\/2026\/05\/NUS_Geromedicine_Unlock_Healthy_Longevity_Day_1-508.jpg 1173w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-inner-column elementor-element elementor-element-944fb1a\" data-id=\"944fb1a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1991a3b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1991a3b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-98a454a\" data-id=\"98a454a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5ad54e0 elementor-widget elementor-widget-spacer\" data-id=\"5ad54e0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The Sorrentino Laboratory The Sorrentino Laboratory is based in the Department of Biochemistry and in the Centre for Healthy Longevity&#8230;<\/p>\n","protected":false},"author":8259,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_canvas","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-8807","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - 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